INT5978

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Context Info
Confidence 0.42
First Reported 1987
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 13
Total Number 13
Disease Relevance 0.72
Pain Relevance 5.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (SIGMAR1) nuclear envelope (SIGMAR1) lipid particle (SIGMAR1)
endoplasmic reticulum (SIGMAR1) plasma membrane (SIGMAR1) nucleus (SIGMAR1)
Anatomy Link Frequency
neurite 1
SIGMAR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
fortral 22 100.00 Very High Very High Very High
Glutamate 8 100.00 Very High Very High Very High
Opioid 6 99.76 Very High Very High Very High
Nerve growth factor 24 99.46 Very High Very High Very High
Inflammation 1 97.44 Very High Very High Very High
agonist 11 97.16 Very High Very High Very High
imagery 2 97.04 Very High Very High Very High
opiate 3 96.84 Very High Very High Very High
antagonist 10 95.52 Very High Very High Very High
antidepressant 18 83.16 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 1 97.44 Very High Very High Very High
Bordatella Infection 4 93.56 High High
Cancer 3 93.36 High High
Glioma 1 57.48 Quite High
Neuroblastoma 1 56.60 Quite High
Cognitive Disorder 2 53.04 Quite High
Aging 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The stimulation of sigma receptor induces transient increase of intracellular calcium and amplifies signals from different stimuli.
Positive_regulation (stimulation) of sigma receptor
1) Confidence 0.42 Published 2005 Journal Georgian Med News Section Abstract Doc Link 16308450 Disease Relevance 0.10 Pain Relevance 0.28
These findings establish a new model for evaluating both sigma2 and sigma1 receptor activity of sigma ligands, which could be useful for developing new ligands having mixed sigma2 agonist/sigma1 antagonist activity as potential antineoplastic agents.
Positive_regulation (evaluating) of sigma1 receptor associated with antagonist and agonist
2) Confidence 0.41 Published 2004 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 15322732 Disease Relevance 0.34 Pain Relevance 0.55
Chronic treatment of cells with (+)PTZ, imipramine, or fluvoxamine also increased Sig-1R.
Positive_regulation (increased) of Sig-1R
3) Confidence 0.36 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12438547 Disease Relevance 0 Pain Relevance 0.74
In separate experiments, we found that NGF dose and time dependently increased Sig-1R in PC12 cells.
Positive_regulation (increased) of Sig-1R associated with nerve growth factor
4) Confidence 0.36 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12438547 Disease Relevance 0 Pain Relevance 0.75
These latter results suggested that NGF induces the neurite sprouting by increasing Sig-1R.
Positive_regulation (increasing) of Sig-1R in neurite associated with nerve growth factor
5) Confidence 0.26 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12438547 Disease Relevance 0 Pain Relevance 0.73
Among opioid compounds, requirements for sigma receptor affinity differ strikingly from the determinants of affinity for conventional opiate receptors.
Positive_regulation (requirements) of sigma receptor associated with opiate and opioid
6) Confidence 0.24 Published 1987 Journal Mol. Pharmacol. Section Abstract Doc Link 2826991 Disease Relevance 0 Pain Relevance 0.78
This enhancement of sigma 2 receptor affinity is accompanied by substantial selectivity of all of these dextrorotatory products for the sigma 2 relative to the sigma 1 subtype (32-238-fold), and thus, they are among the most sigma 2 selective compounds currently known.
Positive_regulation (enhancement) of sigma 2 receptor
7) Confidence 0.14 Published 1995 Journal J. Med. Chem. Section Abstract Doc Link 7490727 Disease Relevance 0 Pain Relevance 0.11
The increased numbers of both sigma1 and sigma2 receptor subtypes in the aged rats compensate for the lowered affinity, and rather enhanced the radioligand-receptor binding.
Positive_regulation (increased) of sigma1
8) Confidence 0.13 Published 2003 Journal Ann Nucl Med Section Abstract Doc Link 12691135 Disease Relevance 0 Pain Relevance 0.20
These compounds were evaluated for sigma receptor affinity and specificity in order to assess their potential as PET/SPECT imaging agents.
Positive_regulation (evaluated) of sigma receptor associated with imagery
9) Confidence 0.11 Published 1992 Journal J. Med. Chem. Section Abstract Doc Link 1319493 Disease Relevance 0 Pain Relevance 0.15
We tested the hypothesis that fentanyl attenuates muscarinic coronary contraction via sigma receptor activation.
Positive_regulation (activation) of sigma receptor
10) Confidence 0.10 Published 1996 Journal Anesth. Analg. Section Abstract Doc Link 8610910 Disease Relevance 0 Pain Relevance 0.07
Sigma receptor activation does not mediate fentanyl-induced attenuation of muscarinic coronary contraction.
Positive_regulation (activation) of Sigma receptor associated with fortral
11) Confidence 0.07 Published 1996 Journal Anesth. Analg. Section Title Doc Link 8610910 Disease Relevance 0 Pain Relevance 0.17
These results suggest that PREGS increases spontaneous glutamate release via activation of a presynaptic G(i/o)-coupled sigma receptor and an elevation in intracellular Ca2+ levels.
Positive_regulation (increases) of sigma receptor associated with glutamate
12) Confidence 0.07 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 12042305 Disease Relevance 0.15 Pain Relevance 0.41
These results suggest that PREGS increases spontaneous glutamate release via activation of a presynaptic G(i/o)-coupled sigma receptor and an elevation in intracellular Ca2+ levels.
Positive_regulation (activation) of sigma receptor associated with glutamate
13) Confidence 0.05 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 12042305 Disease Relevance 0.14 Pain Relevance 0.41

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