INT59870

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Context Info
Confidence 0.65
First Reported 1993
Last Reported 2011
Negated 0
Speculated 5
Reported most in Abstract
Documents 51
Total Number 56
Disease Relevance 51.83
Pain Relevance 14.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (F3) aging (F3) extracellular region (F3)
plasma membrane (F3) cytoplasm (F3)
Anatomy Link Frequency
macrophages 9
platelet 7
blood 4
monocytes 4
leukocytes 4
F3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 170 99.92 Very High Very High Very High
cytokine 266 99.76 Very High Very High Very High
Inflammation 712 99.56 Very High Very High Very High
fibrosis 79 98.68 Very High Very High Very High
Osteoarthritis 12 98.68 Very High Very High Very High
cva 174 98.60 Very High Very High Very High
rheumatoid arthritis 20 98.22 Very High Very High Very High
Inflammatory response 64 95.52 Very High Very High Very High
Inflammatory stimuli 4 92.52 High High
abdominal pain 5 91.16 High High
Disease Link Frequency Relevance Heat
Cancer 587 100.00 Very High Very High Very High
Thrombosis 152 100.00 Very High Very High Very High
Adhesions 130 100.00 Very High Very High Very High
Necrosis 77 100.00 Very High Very High Very High
Thrombocytopenia 18 100.00 Very High Very High Very High
Leukocytosis 1 100.00 Very High Very High Very High
Cv General 3 Under Development 245 99.92 Very High Very High Very High
Thrombophilia 98 99.74 Very High Very High Very High
INFLAMMATION 848 99.56 Very High Very High Very High
Streptococcus Infection 8 99.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We used the following definitions: cardiac failure was defined as requiring use of inotropic agents; respiratory failure was defined as the need for assisted ventilatiory support; ARDS was defined as clinical deterioration with severe arterial hypoxaemia and diffuse bilateral infiltrates on chest radiograph; disseminated intravenous coagulation (DIC) was defined as elevated prothrombin time (PT) with elevated activated partial thromboplastin time (APTT), and decreased fibrinogen (FIB) level with thrombocytopenia; liver function impairment was defined as aminotransferase (ALT or AST) levels ?
Spec (partial) Gene_expression (time) of thromboplastin in chest associated with respiratory failure, thrombocytopenia, disseminated intravascular coagulation, adult respiratory distress syndrome and myocardial infarction
1) Confidence 0.65 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2515635 Disease Relevance 0.56 Pain Relevance 0.07
In case of a severe thrombocytopenia (platelet count < 100,000/mm3), blood coagulation tests (prothrombin time, partial thromboplastin time, fibrinogen, and D-dimers) were performed to diagnose disseminated intravascular coagulation (DIC) syndrome.
Gene_expression (time) of thromboplastin in blood associated with syndrome, disseminated intravascular coagulation and thrombocytopenia
2) Confidence 0.65 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2267812 Disease Relevance 0.95 Pain Relevance 0.24
Tissue factor expressed on macrophages may play an important role in the thrombogenicity in coronary atherosclerotic plaques of these patients.
Gene_expression (expressed) of Tissue factor in macrophages associated with atherosclerotic plaque
3) Confidence 0.49 Published 1997 Journal Arterioscler. Thromb. Vasc. Biol. Section Abstract Doc Link 9351394 Disease Relevance 1.35 Pain Relevance 1.01
Tissue factor expression on macrophages in coronary plaques in patients with unstable angina.
Gene_expression (expression) of Tissue factor in plaques associated with angina
4) Confidence 0.49 Published 1997 Journal Arterioscler. Thromb. Vasc. Biol. Section Title Doc Link 9351394 Disease Relevance 0.90 Pain Relevance 0.76
Fibrin deposition was mainly observed around macrophages expressing tissue factor in the patients with unstable angina.
Gene_expression (expressing) of tissue factor in macrophages associated with angina
5) Confidence 0.49 Published 1997 Journal Arterioscler. Thromb. Vasc. Biol. Section Abstract Doc Link 9351394 Disease Relevance 1.33 Pain Relevance 1.09
The immunohistochemical double staining revealed the expression of tissue factor on macrophages in 18 (75%) of 24 patients with unstable angina versus 3 (13%) of 23 with stable exertional angina (P < .0001).
Gene_expression (expression) of tissue factor in macrophages associated with angina
6) Confidence 0.49 Published 1997 Journal Arterioscler. Thromb. Vasc. Biol. Section Abstract Doc Link 9351394 Disease Relevance 1.33 Pain Relevance 1.10
We have shown that tissue factor expression on macrophages was more frequent in coronary atherosclerotic plaques in patients with unstable angina.
Gene_expression (expression) of tissue factor in plaques associated with atherosclerotic plaque and angina
7) Confidence 0.49 Published 1997 Journal Arterioscler. Thromb. Vasc. Biol. Section Abstract Doc Link 9351394 Disease Relevance 1.31 Pain Relevance 1.06
The purpose of the present study is to determine whether macrophages express tissue factor in human coronary atherosclerotic plaques.
Spec (whether) Gene_expression (express) of tissue factor in macrophages associated with atherosclerotic plaque
8) Confidence 0.49 Published 1997 Journal Arterioscler. Thromb. Vasc. Biol. Section Abstract Doc Link 9351394 Disease Relevance 0.63 Pain Relevance 0.53
Hence, this study investigates whether histamine induces tissue factor (TF) expression in vascular cells.
Gene_expression (expression) of tissue factor
9) Confidence 0.42 Published 2005 Journal Circulation Section Abstract Doc Link 16009787 Disease Relevance 0.45 Pain Relevance 0.09
Routine coagulation tests, such as the prothrombin time and the activated partial thromboplastin time, do not reflect this state, as they are sensitive for coagulation defects not for hypercoagulability [2].
Gene_expression (time) of thromboplastin associated with coagulation disorder and thrombophilia
10) Confidence 0.39 Published 2006 Journal Crit Care Section Body Doc Link PMC1794466 Disease Relevance 0.77 Pain Relevance 0.08
The platelet count, plasma fibrinogen levels, prothrombin time, and activated partial thromboplastin time were assessed at baseline and three times daily.
Gene_expression (levels) of thromboplastin in plasma
11) Confidence 0.39 Published 2006 Journal Crit Care Section Body Doc Link PMC1794466 Disease Relevance 0.44 Pain Relevance 0.10
During Gram-negative septic shock, lipopolysaccharide (LPS, endotoxin) induces tissue factor (TF) expression.
Gene_expression (expression) of tissue factor associated with sepsis
12) Confidence 0.36 Published 1999 Journal Arterioscler. Thromb. Vasc. Biol. Section Abstract Doc Link 10521382 Disease Relevance 0.10 Pain Relevance 0.21
Under sterile and endotoxin-free conditions, the process does not activate tissue factor expression by monocytes.
Gene_expression (expression) of tissue factor in monocytes
13) Confidence 0.35 Published 1999 Journal Haemostasis Section Abstract Doc Link 10844403 Disease Relevance 0 Pain Relevance 0.05
Histamine induces tissue factor expression: implications for acute coronary syndromes.
Gene_expression (expression) of tissue factor associated with acute coronary syndrome
14) Confidence 0.33 Published 2005 Journal Circulation Section Title Doc Link 16009787 Disease Relevance 0.48 Pain Relevance 0.10
Her alanine aminotransferase (ALT) was mildly elevated at 53 U/L (reference range <45 U/L) but other liver function tests, international normalized ration (INR) and activated partial thromboplastin time (APTT), electrolytes, urea, creatinine, amylase, lipase, full blood count, erythrocyte sedimentation rate (ESR), and C-reactive protein, were all within the normal ranges.
Spec (partial) Gene_expression (time) of thromboplastin in blood
15) Confidence 0.28 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2997096 Disease Relevance 0.85 Pain Relevance 0.18
Synthesis of tissue ACE and Tissue Factor (TF), which are known to be direct positive regulators of angiogenesis.
Gene_expression (Synthesis) of Tissue Factor
16) Confidence 0.25 Published 2004 Journal Cardiovasc Diabetol Section Body Doc Link PMC356925 Disease Relevance 0.91 Pain Relevance 0.27
The degree of tissue factor expression has been shown to correlate with metastatic potential and histological differentiation such that increased TF expression results an increased potential to metastasise and a more undifferentiated histological appearance [6,7].
Gene_expression (expression) of tissue factor
17) Confidence 0.25 Published 2005 Journal World J Surg Oncol Section Body Doc Link PMC1156959 Disease Relevance 1.07 Pain Relevance 0.06
In addition, during post-exposure the effect on MPF spread in the other frontal F3 and F4 electrode sites leading to significant differences betweendiesel and sham (Table 2).
Gene_expression (spread) of F3
18) Confidence 0.23 Published 2008 Journal Part Fibre Toxicol Section Body Doc Link PMC2329662 Disease Relevance 0 Pain Relevance 0
Molecular changes which may influence hypercoagulability include the expression of tissue factor (TF) as well as the proteases hepsin and cancer procoagulant by circulating tumour cells [4].
Gene_expression (expression) of tissue factor associated with cancer and thrombophilia
19) Confidence 0.22 Published 2005 Journal World J Surg Oncol Section Body Doc Link PMC1156959 Disease Relevance 0.99 Pain Relevance 0.08
High circulating levels of the procoagulant molecule tissue factor (TF) are associated with thrombosis in a variety of diseases including unstable angina, cancer, and sepsis.
Gene_expression (levels) of tissue factor associated with angina, cancer, disease, sepsis and thrombosis
20) Confidence 0.22 Published 2000 Journal Thromb. Haemost. Section Abstract Doc Link 10744152 Disease Relevance 0.76 Pain Relevance 0.10

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