INT60034

Context Info Confidence 0.68 First Reported 1993 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 40 Total Number 44 Disease Relevance 30.42 Pain Relevance 8.15

extracellular region (VWF) cell adhesion (VWF) endoplasmic reticulum (VWF) proteinaceous extracellular matrix (VWF)

Anatomy Link Frequency plasma 7 platelet 5 endothelial cells 4 megakaryocytes 1 upper limb 1 VWF (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 57 100.00 Inflammatory mediators 4 100.00 Inflammation 246 99.78 Migraine 68 99.78 cocaine 420 99.72 anesthesia 34 99.64 Paracetamol 6 99.56 Inflammatory response 69 99.22 headache 20 98.84 Angina 66 98.52

Disease Link Frequency Relevance Heat INFLAMMATION 316 100.00 Adhesions 107 100.00 Albuminuria 9 99.90 Vasculitis 20 99.86 Headache 85 99.78 Thrombophilia 31 99.52 Thrombosis 195 99.28 Cv General 3 Under Development 78 98.80 Hemolytic Anemia 1 98.76 Congenital Anomalies 28 98.52

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Anatomy

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Speculation

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Furthermore, other factors distinctive to neonates, including gestational age, the increased von Willebrand factor concentration and function, high hematocrit, the large size of erythrocytes and platelet hyporeactivity in the first 10 d of life, affect platelet-vessel wall interaction and influence the interpretation of bleeding time results in newborn infants.

Positive_regulation (increased) of von Willebrand factor in platelet associated with hemorrhage

1) Confidence 0.68 Published 2002 Journal Acta Paediatr Suppl Section Abstract Doc Link 12477268 Disease Relevance 0.90 Pain Relevance 0.11

-B; (3) upregulating angiotensin II type 1 receptor in vascular smooth muscle cells, and directly quenching the production of nitric oxide by endothelial cells [24, 25], resulting in increased production of endothelin-1 [26]; (4) elevation of von Willebrand factor [27], which is known to be associated with endothelial dysfunction.

Positive_regulation (elevation) of von Willebrand factor in endothelial cells

2) Confidence 0.67 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2975076 Disease Relevance 0.98 Pain Relevance 0.08

Aspirin had no influence on the LPS-induced changes of adhesion parameters, but paracetamol blunted the relative increase in vWF while having no effects on the other parameters measured.

Positive_regulation (increase) of vWF associated with aspirin, paracetamol and adhesions

3) Confidence 0.62 Published 1999 Journal Am. J. Respir. Crit. Care Med. Section Abstract Doc Link 10051263 Disease Relevance 1.04 Pain Relevance 0.47

Although aspirin did not have any antiinflammatory effects in this model, paracetamol lowered the relative increase in vWF.

Positive_regulation (increase) of vWF associated with aspirin, paracetamol and inflammation

4) Confidence 0.54 Published 1999 Journal Am. J. Respir. Crit. Care Med. Section Abstract Doc Link 10051263 Disease Relevance 0.78 Pain Relevance 0.46

We observed the following: (1) 1.7-fold higher plasma levels of vWF and ristocetin cofactor activity in UAP patients and (2) 2.8-fold higher levels in the AMI group than in controls.

Positive_regulation (levels) of vWF in plasma associated with angina and myocardial infarction

5) Confidence 0.49 Published 1999 Journal Arterioscler. Thromb. Vasc. Biol. Section Abstract Doc Link 10195912 Disease Relevance 1.23 Pain Relevance 0.36

METHODS: Plasma levels of von Willebrand factor (vWF) antigen, vWF collagen binding activity, vWF-cleaving-protease, CRP, and whole-blood platelet reactivity were measured before and 24 h after angioplasty in 18 patients with recent unstable angina and in 17 with stable angina.

Positive_regulation (levels) of von Willebrand factor in blood platelet

6) Confidence 0.49 Published 2002 Journal J. Thromb. Thrombolysis Section Body Doc Link 12714832 Disease Relevance 0.19 Pain Relevance 0

The results from our study complement these studies and provide further evidence of a trend toward endothelial activation, which was demonstrated by an increase in vWF levels following tourniquet-applied upper limb orthopaedic surgery.

Positive_regulation (increase) of vWF in upper limb

7) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911384 Disease Relevance 0.46 Pain Relevance 0.17

RESULTS: After 1 week of treatment, a significant increase of ATIII (p < 0.05), fV (p < 0.01) and vWF (p < 0.05) was found in the control group, but not in atorvastatin-treated group.

Positive_regulation (increase) of vWF

8) Confidence 0.45 Published 2006 Journal Int. J. Cardiol. Section Body Doc Link 16337041 Disease Relevance 0.08 Pain Relevance 0

Therefore, upregulated VWF may represent unstable hemostasis and reflect damage to endothelial megakaryocytes expressing VWF.

Positive_regulation (upregulated) of VWF in megakaryocytes

9) Confidence 0.43 Published 2010 Journal J Transl Med Section Body Doc Link PMC2984412 Disease Relevance 0.64 Pain Relevance 0.14

Upregulation of VWF and TGF-ß1 mRNA intraoperatively correlated with mortality (p = 0.0021 and 0.009).

Positive_regulation (Upregulation) of VWF

10) Confidence 0.43 Published 2010 Journal J Transl Med Section Body Doc Link PMC2984412 Disease Relevance 0.32 Pain Relevance 0.09

Upregulation of VWF mRNA prognosticated poor clinical condition by multivariate analysis.

Positive_regulation (Upregulation) of VWF mRNA

11) Confidence 0.43 Published 2010 Journal J Transl Med Section Body Doc Link PMC2984412 Disease Relevance 0.52 Pain Relevance 0.06

Factor VIII and von Willebrand factor were reproducibly elevated to high activity levels over a period of 12 months in absence of acute or chronic inflammatory reaction.

Positive_regulation (elevated) of von Willebrand factor associated with inflammation

12) Confidence 0.43 Published 2002 Journal Z Gastroenterol Section Abstract Doc Link 12055664 Disease Relevance 0.84 Pain Relevance 0.17

Increased circulating levels of vWF, PAI-1, t-PA, TFPI, and s-TM have been reported in patients with NIDDM (Collier et al 1992; McGill et al 1994; Bagg et al 2001; Aso et al 2002; Leurs et al 2002; Rigla et al 2006).

Positive_regulation (Increased) of vWF associated with diabetes mellitus

13) Confidence 0.39 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663449 Disease Relevance 1.21 Pain Relevance 0.04

Plasma vWF, TFPI and s-TM levels were significantly increased compared with controls only in patients exhibiting vascular complications.

Positive_regulation (increased) of vWF in Plasma

14) Confidence 0.39 Published 2008 Journal Vascular Health and Risk Management Section Abstract Doc Link PMC2663449 Disease Relevance 1.03 Pain Relevance 0.04

In contrast, the desmoplastic reaction surrounding all 10 pancreatic adenocarcinoma specimens displayed intense interstitial staining for alpha-SMA, SMMHC, and collagen IV but no staining for von Willebrand factor and cluster of differentiation 31.

Neg (no) Positive_regulation (staining) of von Willebrand factor

15) Confidence 0.34 Published 2002 Journal Surgery Section Body Doc Link 11854689 Disease Relevance 0.07 Pain Relevance 0

Those with dependant cocaine usage showed elevations in C-reactive protein, von Willebrand factor and fibrinogen.

Positive_regulation (elevations) of von Willebrand factor associated with cocaine

16) Confidence 0.33 Published 2007 Journal Subst Abuse Treat Prev Policy Section Body Doc Link PMC2042971 Disease Relevance 0.54 Pain Relevance 0.41

They also concluded that an increase in von Willebrand factor without a compensatory change in endogenous fibrinolysis may trigger platelet adhesion, aggregation, and intravascular thrombosis.

Positive_regulation (increase) of von Willebrand factor in platelet associated with thrombosis and adhesions

17) Confidence 0.33 Published 2007 Journal Subst Abuse Treat Prev Policy Section Body Doc Link PMC2042971 Disease Relevance 0.66 Pain Relevance 0.40

Multivariate regression analysis showed that upregulation of IL-6, VWF and TGF-?

Positive_regulation (upregulation) of VWF

18) Confidence 0.29 Published 2010 Journal J Transl Med Section Abstract Doc Link PMC2984412 Disease Relevance 0.22 Pain Relevance 0.12

Thrombophilia screening demonstrated elevated factor VIII levels (206 %) and von Willebrand factor levels (> 440 %).

Positive_regulation (elevated) of von Willebrand factor associated with thrombophilia

19) Confidence 0.29 Published 2002 Journal Z Gastroenterol Section Abstract Doc Link 12055664 Disease Relevance 0.88 Pain Relevance 0.18

Increased levels of factor VIII and von Willebrand factor may play a pathogenetic role in the development of portal, splenic, and mesenteric thrombosis.

Positive_regulation (Increased) of von Willebrand factor associated with thrombosis

20) Confidence 0.29 Published 2002 Journal Z Gastroenterol Section Abstract Doc Link 12055664 Disease Relevance 0.89 Pain Relevance 0.17

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