INT60035

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Context Info
Confidence 0.42
First Reported 1993
Last Reported 2009
Negated 2
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 6.26
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (VWF) cell adhesion (VWF) endoplasmic reticulum (VWF)
proteinaceous extracellular matrix (VWF)
Anatomy Link Frequency
ankle 2
plasma 1
VWF (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 66 99.88 Very High Very High Very High
Opioid 1 89.00 High High
noradrenaline 1 67.36 Quite High
aspirin 6 50.00 Quite Low
cocaine 1 33.68 Quite Low
Inflammatory response 10 29.76 Quite Low
headache 5 25.92 Quite Low
Migraine 2 25.36 Quite Low
Pain 4 25.00 Low Low
cva 3 25.00 Low Low
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 37 100.00 Very High Very High Very High
INFLAMMATION 78 99.88 Very High Very High Very High
Acute Coronary Syndrome 19 98.92 Very High Very High Very High
Stress 14 97.24 Very High Very High Very High
Malaria 34 97.12 Very High Very High Very High
Hemorrhage 4 96.72 Very High Very High Very High
Syndrome 2 95.20 Very High Very High Very High
Infection 17 94.12 High High
Disease 50 93.88 High High
Nicotine Addiction 370 89.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, the introduction of S/D treatment did not alter the PK characteristics and function of VWF and FVIII molecules of Immunate S/D which is effective and safe for treatment of bleeding episodes, management of surgical procedures, and prophylaxis.
Neg (not) Regulation (alter) of VWF associated with hemorrhage
1) Confidence 0.42 Published 2007 Journal Haemophilia Section Abstract Doc Link 17212718 Disease Relevance 0.49 Pain Relevance 0
However, significant rises in vWF levels have also been demonstrated in patients with naturally acquired malaria without the development of any coronary syndromes [38].
Regulation (rises) of vWF associated with malaria and syndrome
2) Confidence 0.17 Published 2009 Journal Malar J Section Body Doc Link PMC2794284 Disease Relevance 1.78 Pain Relevance 0.10
Recently, Becker et al. [149] have suggested that the significant relationship between elevated systemic sICAM-1 and vascular disease is independent of renal function and major risk factors such as clinical or sub-clinical atherosclerosis (prior vascular disease or ankle-brachial pressure index), endothelial activation (von Willebrand factor), inflammation (C-reactive protein), or elevated sVCAM-1.
Regulation (independent) of von Willebrand factor in ankle associated with inflammation and increased venous pressure under development
3) Confidence 0.08 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2669563 Disease Relevance 1.53 Pain Relevance 0.09
Recently, Becker et al. [149] have suggested that the significant relationship between elevated systemic sICAM-1 and vascular disease is independent of renal function and major risk factors such as clinical or sub-clinical atherosclerosis (prior vascular disease or ankle-brachial pressure index), endothelial activation (von Willebrand factor), inflammation (C-reactive protein), or elevated sVCAM-1.
Neg (independent) Regulation (independent) of von Willebrand factor in ankle associated with inflammation and increased venous pressure under development
4) Confidence 0.08 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2671531 Disease Relevance 1.53 Pain Relevance 0.09
Anaesthesia affects plasma concentrations of vasopressin, von Willebrand factor and coagulation factor VIII in cardiac surgical patients.
Regulation (affects) of von Willebrand factor in plasma
5) Confidence 0.07 Published 1993 Journal Br J Anaesth Section Title Doc Link 8435262 Disease Relevance 0.92 Pain Relevance 0.12
P-selectin levels were not elevated at any time point but von Willebrand factor values were elevated at baseline and remained elevated at days 7 and 30.
Regulation (values) of von Willebrand factor
6) Confidence 0.06 Published 2002 Journal Eur. Heart J. Section Body Doc Link 12419297 Disease Relevance 0 Pain Relevance 0

General Comments

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