INT60126

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Context Info
Confidence 0.62
First Reported 1993
Last Reported 2010
Negated 14
Speculated 34
Reported most in Abstract
Documents 186
Total Number 220
Disease Relevance 85.53
Pain Relevance 133.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Trpv1) plasma membrane (Trpv1) lipid metabolic process (Trpv1)
Anatomy Link Frequency
DRG 15
neurons 14
primary sensory neurons 6
sensory neurons 5
nerve 5
Trpv1 (Rattus norvegicus)
Trpv1 - S800A (1)
Pain Link Frequency Relevance Heat
qutenza 3235 100.00 Very High Very High Very High
Pain 1317 100.00 Very High Very High Very High
Inflammation 814 100.00 Very High Very High Very High
antagonist 775 100.00 Very High Very High Very High
Calcitonin gene-related peptide 594 100.00 Very High Very High Very High
Nerve growth factor 584 100.00 Very High Very High Very High
agonist 485 100.00 Very High Very High Very High
Analgesic 325 100.00 Very High Very High Very High
substance P 212 100.00 Very High Very High Very High
nociceptor 192 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 1109 100.00 Very High Very High Very High
INFLAMMATION 709 100.00 Very High Very High Very High
Nociception 609 100.00 Very High Very High Very High
Nervous System Injury 124 100.00 Very High Very High Very High
Pain 1269 99.92 Very High Very High Very High
Neuropathic Pain 772 99.92 Very High Very High Very High
Targeted Disruption 90 99.88 Very High Very High Very High
Hypersensitivity 79 99.82 Very High Very High Very High
Hyperalgesia 573 99.76 Very High Very High Very High
Fever 222 99.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have explored its ability to modulate TRPV1 receptors and voltage-gated sodium channels.
Regulation (modulate) of TRPV1 associated with sodium channel
1) Confidence 0.62 Published 2004 Journal J. Neurophysiol. Section Abstract Doc Link 14657192 Disease Relevance 0.36 Pain Relevance 0.69
Inflammatory mediators (BK, substance P) also modulate TRPV1 activity.
Regulation (modulate) of TRPV1 associated with inflammatory mediators and substance p
2) Confidence 0.62 Published 2008 Journal Inflamm. Res. Section Abstract Doc Link 18777111 Disease Relevance 0.26 Pain Relevance 0.45
We conclude that TRPV1(VAR) is one of perhaps several TRPV1 splice variants expressed in rat kidney and that it may serve to modulate TRPV1 responsiveness in some tissues.
Regulation (modulate) of TRPV1 in kidney
3) Confidence 0.62 Published 2006 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 16091583 Disease Relevance 0 Pain Relevance 0
Based on the data shown here, we conclude that it is feasible to modulate TRPV1 in a manner that does not cause hyperthermia while maintaining efficacy in rodent pain models.
Regulation (modulate) of TRPV1 associated with pain and fever
4) Confidence 0.62 Published 2008 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 18420600 Disease Relevance 0.64 Pain Relevance 0.62
Thus, the qualitative signaling properties of TRPV1 are dynamically modulated during channel activation, a process that probably shapes TRPV1 participation in pain, cytotoxicity and neurotransmitter release.
Regulation (modulated) of TRPV1 associated with pain and neurotransmitter
5) Confidence 0.62 Published 2008 Journal Nat. Neurosci. Section Abstract Doc Link 18391945 Disease Relevance 0.10 Pain Relevance 0.43
Considering that the expression of DRG TRPV1 receptors can be up-regulated in response to peripheral inflammation [26], it would be of interest to determine whether TRPV1 receptors of the ACC and somatosensory cortex can be similarly regulated.


Regulation (regulated) of TRPV1 in cortex associated with somatosensory cortex, inflammation and anterior cingulate cortex
6) Confidence 0.62 Published 2006 Journal Mol Pain Section Body Doc Link PMC1647269 Disease Relevance 0.51 Pain Relevance 1.11
Paratracheal injection of short interfering RNA targeting TRPV1 blocked TRPV1 up-regulation in cervical DRG and abolished inflammation-mediated HPL reductions seen at 50 degrees C.
Regulation (targeting) of TRPV1 in DRG associated with inflammation
7) Confidence 0.62 Published 2007 Journal Eur. J. Neurosci. Section Abstract Doc Link 17509082 Disease Relevance 1.62 Pain Relevance 0.98
This study provides evidence that muscle pH may be important in modulating P2X and TRPV1 responsiveness in exercising muscle.
Regulation (responsiveness) of TRPV1 in muscle
8) Confidence 0.62 Published 2007 Journal J. Appl. Physiol. Section Abstract Doc Link 17379752 Disease Relevance 0.09 Pain Relevance 0.24
Regulation of calcitonin gene-related peptide and TRPV1 in a rat model of osteoarthritis.
Regulation (Regulation) of TRPV1 associated with pain, osteoarthritis and calcitonin gene-related peptide
9) Confidence 0.62 Published 2005 Journal Neurosci. Lett. Section Title Doc Link 16039054 Disease Relevance 0.93 Pain Relevance 1.08
Function and regulation of the vanilloid receptor in rats fed a high salt diet.
Regulation (regulation) of vanilloid receptor associated with qutenza
10) Confidence 0.61 Published 2003 Journal J. Hypertens. Section Title Doc Link 12872047 Disease Relevance 0 Pain Relevance 0.15
When combined with other TRPV1 agonists, NiSO4 produces a bimodal effect on TRPV1 activity, depending on the strength and concentration of the second stimulus.
Regulation (effect) of TRPV1 associated with agonist
11) Confidence 0.61 Published 2010 Journal Pflugers Arch. Section Abstract Doc Link 20101408 Disease Relevance 0.07 Pain Relevance 0.35
Regulation of the vanilloid receptor was further characterized in the rat.
Regulation (Regulation) of vanilloid receptor
12) Confidence 0.61 Published 1993 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 8446186 Disease Relevance 0.19 Pain Relevance 0.59
It was the aim of the present study to investigate by RT-PCR the regulation of the mRNA of the neurosteroid-synthesizing enzyme 3beta-hydroxysteroid dehydrogenase (3beta-HSD) and of the vanilloid receptor TRPV1 in dorsal root ganglia (DRGs) of rats during the process of capsaicin denervation of primary sensory neurons and the following regeneration.
Regulation (regulation) of TRPV1 in primary sensory neurons associated with qutenza
13) Confidence 0.61 Published 2005 Journal Pharmacology Section Abstract Doc Link 15492487 Disease Relevance 0 Pain Relevance 0.48
Similarly to peripheral sites, sensitization associated with an up-regulation of spinal TRPV1 receptor is thought to be at the base of the development of mechanical allodynia in the chronic constriction injury of the sciatic nerve [72].
Regulation (regulation) of TRPV1 receptor in sciatic nerve associated with allodynia, eae, injury and sciatic nerve
14) Confidence 0.61 Published 2010 Journal Mol Pain Section Body Doc Link PMC2959024 Disease Relevance 1.18 Pain Relevance 1.57
The up-regulation of the TRPV1 receptor at peripheral and central nervous system level in neuropathic pain conditions provides morphological evidence that the sensitivity of the vanilloid system in this painful condition is increased (conversely to the opioid system), therefore making the TRPV1 channel a suitable candidate for the future development of novel neuropathic pain relieving agents.
Regulation (regulation) of TRPV1 receptor in central nervous system associated with pain, neuropathic pain, central nervous system and opioid
15) Confidence 0.61 Published 2010 Journal Mol Pain Section Body Doc Link PMC2959024 Disease Relevance 0.86 Pain Relevance 1.33
Phosphorylation and dephosphorylation reactions regulate TRPV1 receptor activity and proved to be crucial in promoting inflammatory pain.
Regulation (regulate) of TRPV1 receptor associated with eae
16) Confidence 0.61 Published 2010 Journal Mol Pain Section Body Doc Link PMC2959024 Disease Relevance 0.58 Pain Relevance 1.01
Therefore by simultaneously targeting FAAH enzyme and TRPV1 receptors, two different targets controlling nociception in distinct ways, this hybrid molecule could represent an alternative approach to be used in the treatment of neuropathic pain.
Regulation (targeting) of TRPV1 associated with nociception and neuropathic pain
17) Confidence 0.61 Published 2010 Journal Mol Pain Section Body Doc Link PMC2959024 Disease Relevance 0.85 Pain Relevance 0.94
This newly understood and yet to be fully validated aspect of pain suggests that pain management based on regulating the TRPV1 receptor might require a personalized approach for effective clinical outcome.
Regulation (regulating) of TRPV1 receptor associated with pain and pain management
18) Confidence 0.61 Published 2009 Journal Trends Mol Med Section Abstract Doc Link 19097938 Disease Relevance 0.46 Pain Relevance 0.85
In this study, we examined the role of the nonreceptor cellular tyrosine kinase c-Src kinase in the modulation of the rat TRPV1.
Regulation (modulation) of TRPV1
19) Confidence 0.61 Published 2004 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 15084474 Disease Relevance 0.09 Pain Relevance 0.37
Conclusions: The duodenal hyperemic response to luminal CO(2) is dependent on cytosolic and membrane-bound CA isoforms, NHE-1, and TRPV1.
Regulation (dependent) of TRPV1
20) Confidence 0.61 Published 2006 Journal Gastroenterology Section Body Doc Link 16831598 Disease Relevance 0 Pain Relevance 0

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