INT60148

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Context Info
Confidence 0.43
First Reported 1993
Last Reported 2010
Negated 2
Speculated 4
Reported most in Abstract
Documents 20
Total Number 24
Disease Relevance 7.23
Pain Relevance 7.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Sigmar1) nuclear envelope (Sigmar1) lipid particle (Sigmar1)
endoplasmic reticulum (Sigmar1) plasma membrane (Sigmar1) nucleus (Sigmar1)
Anatomy Link Frequency
pancreas 2
vas deferens 2
spinal 1
muller cells 1
Sigmar1 (Mus musculus)
Pain Link Frequency Relevance Heat
fortral 60 100.00 Very High Very High Very High
Dopamine 11 100.00 Very High Very High Very High
opioid receptor 8 100.00 Very High Very High Very High
Kinase C 5 100.00 Very High Very High Very High
agonist 23 99.96 Very High Very High Very High
Opioid 9 99.84 Very High Very High Very High
antidepressant 3 99.68 Very High Very High Very High
Pain 7 99.60 Very High Very High Very High
analgesia 5 99.56 Very High Very High Very High
potassium channel 6 99.08 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 5 99.60 Very High Very High Very High
Hyperplasia 4 99.48 Very High Very High Very High
Nociception 3 99.40 Very High Very High Very High
Pancreatic Cancer 143 99.12 Very High Very High Very High
Immunotherapy Of Cancer 6 98.96 Very High Very High Very High
Cancer 350 98.64 Very High Very High Very High
Overdose 1 98.52 Very High Very High Very High
Amnesia 3 98.28 Very High Very High Very High
Convulsion 2 96.52 Very High Very High Very High
Apoptosis 226 96.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Similar results were obtained with Hcy. sigmaR1 mRNA and protein levels did not change in the presence of the excitotoxins.
Neg (not) Regulation (change) of sigmaR1 mRNA
1) Confidence 0.43 Published 2007 Journal Invest. Ophthalmol. Vis. Sci. Section Body Doc Link 17898305 Disease Relevance 0 Pain Relevance 0
These results indicate that sigma receptor ligands regulate the neurogenic twitch contraction, which is mediated by rimcazole-sensitive benzomorphan-type sigma receptors.
Regulation (regulate) of sigma receptor
2) Confidence 0.42 Published 1993 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8449236 Disease Relevance 0 Pain Relevance 0.26
The effects of sigma receptor ligands on the neurogenic twitch contraction in the ddY mouse vas deferens were studied.
Regulation (effects) of sigma receptor in vas deferens
3) Confidence 0.42 Published 1993 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8449236 Disease Relevance 0 Pain Relevance 0.16
The data indicates a possible role for sigma receptor ligands in the treatment of cocaine overdose and addiction.
Spec (possible) Regulation (role) of sigma receptor associated with addiction, overdose and cocaine
4) Confidence 0.41 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10334496 Disease Relevance 0.41 Pain Relevance 0.62
To evaluate the effect of sigma-2 receptor ligands both systemically and on tumor in vivo, several mice were sacrificed after a single treatment.
Regulation (effect) of sigma-2 receptor associated with cancer
5) Confidence 0.41 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1939854 Disease Relevance 0.64 Pain Relevance 0
The effects of sigma-receptor ligands on the twitch contraction elicited by the exogenous application of adenosine 5'-triphosphate (ATP) in the unstimulated mouse vas deferens were studied. (-)-Pentazocine, 1,3-di(2-tolyl)guanidine(DTG) and two pairs of optical isomers of 3-(3-hydroxyphenyl)-N-(1-propyl)piperidine(3-PPP) and N-allylnormetazocine (SKF-10,047) potentiated the exogenous application of ATP-induced twitch-type contraction in a concentration-dependent manner, while (+)-pentazocine did not affect it.
Regulation (effects) of sigma-receptor in vas deferens associated with fortral and adenocard
6) Confidence 0.41 Published 1996 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 8722504 Disease Relevance 0 Pain Relevance 0.28
Herein, we examined the effects of sigma 1 receptor ligands on the beta 25-35 peptide-induced amnesia.
Spec (examined) Regulation (effects) of sigma 1 receptor associated with amnesia
7) Confidence 0.39 Published 1998 Journal Neuroscience Section Abstract Doc Link 9460750 Disease Relevance 0.52 Pain Relevance 0.35
Involvement of sigma-1 receptor modulation in the antidepressant action of venlafaxine.
Regulation (modulation) of sigma-1 receptor associated with fortral and antidepressant
8) Confidence 0.36 Published 2007 Journal Neurosci. Lett. Section Title Doc Link 17532136 Disease Relevance 0.09 Pain Relevance 0.67
Effects of sigma receptor agonists on the impairment of spontaneous alternation behavior and decrease of cyclic GMP level induced by nitric oxide synthase inhibitors in mice.
Regulation (Effects) of sigma receptor associated with fortral and agonist
9) Confidence 0.35 Published 2000 Journal Neuropharmacology Section Title Doc Link 10974323 Disease Relevance 0 Pain Relevance 0.40
The aim of this study was to investigate the effects of several intravenous anaesthetics on the sigma-1 receptor.
Regulation (effects) of sigma-1 receptor
10) Confidence 0.35 Published 2006 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 16879472 Disease Relevance 0 Pain Relevance 0.17
To demonstrate the specificity of SW120 for Sigma-2 receptor binding, 10?
Regulation (specificity) of Sigma-2 receptor
11) Confidence 0.34 Published 2009 Journal J Transl Med Section Body Doc Link PMC2669042 Disease Relevance 0.32 Pain Relevance 0.10
Sigma1 receptor modulation of opioid analgesia in the mouse.
Regulation (modulation) of Sigma1 receptor associated with fortral, opioid and analgesia
12) Confidence 0.31 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 11861817 Disease Relevance 0 Pain Relevance 1.34
The present study was designed to examine the effect of different PKC isoform inhibitors on sigma-1 receptor-mediated pain facilitation and increased spinal pNR1 expression in mice.
Spec (examine) Regulation (effect) of sigma-1 receptor in spinal associated with pain and kinase c
13) Confidence 0.29 Published 2010 Journal Neurosci. Lett. Section Abstract Doc Link 20417251 Disease Relevance 0.25 Pain Relevance 0.78
It has been previously demonstrated [11,24,25], that sigma-1 receptors modulate the activity of Kv1.4 potassium channels.
Regulation (modulate) of sigma-1 associated with potassium channel
14) Confidence 0.28 Published 2007 Journal J Mol Signal Section Body Doc Link PMC2045653 Disease Relevance 0.07 Pain Relevance 0.14
This study examined the expression, subcellular localization, binding activity, and regulation of sigmaR1 in retinal Müller cells.
Regulation (regulation) of sigmaR1
15) Confidence 0.27 Published 2006 Journal Invest. Ophthalmol. Vis. Sci. Section Abstract Doc Link 17122151 Disease Relevance 0 Pain Relevance 0
Expression, subcellular localization, and regulation of sigma receptor in retinal muller cells.
Regulation (regulation) of sigma receptor in muller cells associated with fortral
16) Confidence 0.27 Published 2006 Journal Invest. Ophthalmol. Vis. Sci. Section Title Doc Link 17122151 Disease Relevance 0 Pain Relevance 0.20
A series of (+)-cis-N-normetazocine derivatives has been described, and their affinities for sigma1, sigma2, and phencyclidine (PCP) sites and opioid, muscarinic (M2), dopamine (D2), and serotonin (5-HT2) receptors were evaluated.
Regulation (affinities) of sigma1 associated with dopamine, serotonin and opioid
17) Confidence 0.27 Published 1998 Journal J. Med. Chem. Section Abstract Doc Link 9572883 Disease Relevance 0 Pain Relevance 0.33
In this study, we examined the effects of several antisense oligodeoxynucleotides (antisenses) to kappa1-opioid receptors and sigma1 receptor on memory and nociceptive function.
Spec (examined) Regulation (effects) of sigma1 receptor associated with nociception and opioid receptor
18) Confidence 0.25 Published 2004 Journal Brain Res. Section Abstract Doc Link 15571673 Disease Relevance 0.10 Pain Relevance 0.52
By establishing that pancreas cancer cell lines and Panc-02 tumor allografts established in C57Bl/6 mice respond similarly to sigma-2 receptor ligands, we have extended the utility of these molecules and are demonstrating the generality of targeting the sigma-2 receptor for both diagnostic and therapeutic applications.
Regulation (targeting) of sigma-2 receptor in pancreas associated with cancer and pancreatic cancer
19) Confidence 0.25 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1939854 Disease Relevance 1.19 Pain Relevance 0
We have identified the sigma-2 receptor as a potential target for the treatment of pancreas cancer; selectively triggering or sensitizing tumor cells toward apoptosis.


Regulation (target) of sigma-2 receptor in pancreas associated with cancer, pancreatic cancer and apoptosis
20) Confidence 0.25 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1939854 Disease Relevance 1.31 Pain Relevance 0.05

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