INT60199

Context Info Confidence 0.49 First Reported 1993 Last Reported 2005 Negated 0 Speculated 0 Reported most in Abstract Documents 5 Total Number 6 Disease Relevance 1.30 Pain Relevance 2.34

cytosol (JUN) nucleoplasm (JUN) nuclear chromosome (JUN) aging (JUN) nucleus (JUN) DNA binding (JUN)

Anatomy Link Frequency glial cells 2 JUN (Homo sapiens)

Pain Link Frequency Relevance Heat Opioid 9 98.84 Neuropeptide 1 98.80 withdrawal 6 98.40 Enkephalin 13 86.04 cocaine 4 82.96 drug abuse 2 81.40 Cholecystokinin 5 80.48 Kinase C 1 79.44 cINOD 2 76.28 opioid receptor 1 75.00

Disease Link Frequency Relevance Heat Colon Cancer 4 88.76 Opiate Addiction 1 88.64 Neuroblastoma 2 88.16 Apoptosis 5 87.32 Rheumatoid Arthritis 1 84.88 Drug Dependence 2 81.40 Cancer 2 77.64 INFLAMMATION 1 75.72 Neurological Disease 1 46.48 Htlv Types I And Ii 1 45.20

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The tax1 induced c-Fos protein levels and the concurrently increased association of c-Fos/c-Jun transcription factors at the AP-1 site imply a strong functional significance in the activation of proenkephalin gene expression in tax1 expressing glial cells.

Positive_regulation (increased) of c-Jun Binding (association) of in glial cells

1) Confidence 0.49 Published 1997 Journal J. Neurovirol. Section Abstract Doc Link 9147818 Disease Relevance 0 Pain Relevance 0.14

After 1 h or 96 h of treatment, Fos and Jun protein levels were altered and the DNA-binding activity of AP-1 was increased in response to both substances.

Positive_regulation (increased) of AP-1 Binding (binding) of

2) Confidence 0.46 Published 2005 Journal Neuropharmacology Section Abstract Doc Link 15814102 Disease Relevance 0.08 Pain Relevance 0.35

After 1 h or 96 h of treatment, Fos and Jun protein levels were altered and the DNA-binding activity of AP-1 was increased in response to both substances.

Positive_regulation (increased) of AP-1 Binding (activity) of

3) Confidence 0.46 Published 2005 Journal Neuropharmacology Section Abstract Doc Link 15814102 Disease Relevance 0.08 Pain Relevance 0.35

Neuropeptide gene expression, i.e. proenkephalin A, may be modulated by activating protein (AP-1) transcription factor complexes which associate with specific DNA sequence motifs, known as the AP-1 binding sites.

Positive_regulation (activating) of AP-1 Binding (associate) of associated with neuropeptide

4) Confidence 0.18 Published 1993 Journal Neuroreport Section Abstract Doc Link 8453059 Disease Relevance 0.09 Pain Relevance 0.23

Among the two potential trans-acting factors that activate Nur77-promoter, indomethacin induced DNA binding and reporter gene activity of AP-1, but not that of related serum response factor (RSRF), suggesting that the transcriptional induction of Nur77 may be mediated through activation of AP-I.

Positive_regulation (induced) of AP-1 Binding (binding) of

5) Confidence 0.17 Published 2000 Journal Biol. Pharm. Bull. Section Abstract Doc Link 10919358 Disease Relevance 0.89 Pain Relevance 0.15

Along with CREB, AP-1 binding activity and AP-1-directed transcription were stimulated after single administration and during withdrawal from the opioid.

Positive_regulation (stimulated) of AP-1 Binding (binding) of associated with opioid and withdrawal

6) Confidence 0.05 Published 2004 Journal J. Neurochem. Section Abstract Doc Link 15287893 Disease Relevance 0.16 Pain Relevance 1.12

General Comments

This test has worked.