INT60220

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Context Info
Confidence 0.38
First Reported 1993
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 0.52
Pain Relevance 1.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Acot1) mitochondrion (Acot1) lipid metabolic process (Acot1)
cytoplasm (Acot1)
Anatomy Link Frequency
BSM 2
ganglia 2
Acot1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 52 98.60 Very High Very High Very High
Catecholamine 14 98.56 Very High Very High Very High
tetrodotoxin 11 96.84 Very High Very High Very High
Neurotransmitter 25 95.68 Very High Very High Very High
antagonist 28 88.40 High High
dopamine receptor 4 77.40 Quite High
gABA 129 56.88 Quite High
Dopamine 75 53.96 Quite High
GABA receptor 9 45.28 Quite Low
GABAergic 13 9.12 Low Low
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 3 83.72 Quite High
Hypertension 5 81.44 Quite High
Disease 15 80.60 Quite High
Hypersensitivity 4 72.64 Quite High
Asthma 16 71.92 Quite High
Metabolic Syndrome 8 64.08 Quite High
Airway Obstruction 2 34.16 Quite Low
Immunization 2 32.88 Quite Low
Occupational Lung Diseases 4 24.12 Low Low
Ganglion Cysts 26 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
If the ganglia were dissociated before plating, there was a selective increase in ACh synthesis (three- to fivefold) such that the CA:ACh ratio fell strikingly.
Positive_regulation (increase) of Gene_expression (synthesis) of ACh in ganglia associated with catecholamine
1) Confidence 0.38 Published 1993 Journal J. Neurosci. Res. Section Abstract Doc Link 8455211 Disease Relevance 0 Pain Relevance 0.35
A preferential stimulation of ACh production was also observed when the concentration of K+ was raised to 20 mM.
Positive_regulation (stimulation) of Gene_expression (production) of ACh
2) Confidence 0.38 Published 1993 Journal J. Neurosci. Res. Section Abstract Doc Link 8455211 Disease Relevance 0 Pain Relevance 0.35
The expression of CTE-I can be induced by fasting; that is the expression is increased during the light phase and declined during the dark phase when feeding activity is abundant [44].
Positive_regulation (induced) of Gene_expression (expression) of CTE-I
3) Confidence 0.25 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943104 Disease Relevance 0.13 Pain Relevance 0.03
Moreover, it has also been reported that there is no difference between normal and antigen-induced AHR animals in ACh-induced increase in intracellular Ca2+ concentration in BSMs, irrespective of a great difference in ACh-induced BSM contraction [29,30].
Positive_regulation (induced) of Gene_expression (contraction) of ACh-induced
4) Confidence 0.07 Published 2005 Journal Respir Res Section Body Doc Link PMC545934 Disease Relevance 0 Pain Relevance 0.08
A participation of RhoA-mediated Ca2+ sensitization in the augmented ACh-induced contraction of BSM was demonstrated in this animal model of AHR.


Positive_regulation (augmented) of Gene_expression (contraction) of ACh-induced in BSM
5) Confidence 0.07 Published 2005 Journal Respir Res Section Body Doc Link PMC545934 Disease Relevance 0.39 Pain Relevance 0.07
Neither activation of ACh receptors with the nonselective cholinergic agonist carbamoylcholine chloride (100 ?
Positive_regulation (activation) of Gene_expression (receptors) of ACh associated with agonist
6) Confidence 0.06 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2567003 Disease Relevance 0 Pain Relevance 0.61

General Comments

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