INT60554

Context Info Confidence 0.40 First Reported 1993 Last Reported 2010 Negated 0 Speculated 1 Reported most in Body Documents 30 Total Number 33 Disease Relevance 7.99 Pain Relevance 3.02

molecular_function (Coq10a) cellular_component (Coq10a) biological_process (Coq10a)

Anatomy Link Frequency NG108-15 1 brains 1 PSP 1 T lymphocytes 1 Coq10a (Mus musculus)

Pain Link Frequency Relevance Heat Enkephalin 6 100.00 depression 3 98.84 opioid receptor 10 98.04 Calcium channel 4 97.28 projection neuron 3 96.80 opiate 2 95.92 Substantia nigra 32 94.92 narcan 2 94.40 fibrosis 20 92.96 Opioid 19 92.00

Disease Link Frequency Relevance Heat Supranuclear Palsy 18 100.00 Vibrio Infection 45 99.84 Depression 3 98.84 Adhesions 20 98.40 Disease 244 98.36 Targeted Disruption 50 97.84 Alzheimer's Dementia 134 96.88 Apoptosis 87 96.20 Neuroblastoma 24 95.48 Death 135 94.32

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Clinical assessments using UPDRS III, Hoehn and Yahr stage, MMSE, and Montgomery Asberg Depression Scale showed no change.91 Currently a phase III trial of CoQ10 in PSP patients is recruiting, with a goal of 60 patients undergoing treatment with CoQ10 for one year (NCT00382824).

CoQ10 Binding (recruiting) of in PSP associated with depression and supranuclear palsy

1) Confidence 0.40 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2785862 Disease Relevance 1.06 Pain Relevance 0.05

Taking advantage of barely detectable quantities of GM1 expressed in NECs (Yanagisawa et al., 2006a), we evaluated the incorporation of GM1 into the NECs by staining with Ctxb, a probe recognizing GM1 and other related gangliosides.

GM1 Binding (recognizing) of

2) Confidence 0.39 Published 2010 Journal ASN NEURO Section Body Doc Link PMC2838405 Disease Relevance 0.06 Pain Relevance 0

Our previous study using surface plasmon resonance and a liposome capture method showed that GM1 directly bound to A?

GM1 Binding (bound) of

3) Confidence 0.39 Published 2010 Journal ASN NEURO Section Body Doc Link PMC2838405 Disease Relevance 0.53 Pain Relevance 0.03

T lymphocytes, isolated from beta-endorphin-treated donors, and then depleted with anti-asialo GM1 antiserum and complement failed to demonstrate the detrimental effects of beta-endorphin.

GM1 Binding (depleted) of in T lymphocytes

4) Confidence 0.36 Published 1993 Journal J. Neuroimmunol. Section Abstract Doc Link 8505409 Disease Relevance 0.18 Pain Relevance 0.18

-(1–40) strongly interacts with GM1 only in the presence of cholesterol and sphingomyelin, components of cell surface microdomains, as reported by Kakio et al. (2001); the interaction between GM1 and FITC-A?

GM1 Binding (interaction) of

5) Confidence 0.35 Published 2010 Journal ASN NEURO Section Body Doc Link PMC2838405 Disease Relevance 0.06 Pain Relevance 0

Then, we analysed the physical interaction between GM1 and FITC-A?

GM1 Spec (analysed) Binding (interaction) of

6) Confidence 0.35 Published 2010 Journal ASN NEURO Section Body Doc Link PMC2838405 Disease Relevance 0.06 Pain Relevance 0

First, we confirmed the efficiency of the assay by detecting the interaction between GM1 and the well-known ligand, Ctxb.

GM1 Binding (interaction) of

7) Confidence 0.35 Published 2010 Journal ASN NEURO Section Body Doc Link PMC2838405 Disease Relevance 0.12 Pain Relevance 0

Bicelles containing GM1 were found to interact strongly with leucine enkephalin, whereas a somewhat weaker interaction was observed in the case of bicelles without GM1.

GM1 Binding (interaction) of associated with enkephalin

8) Confidence 0.32 Published 2008 Journal Langmuir Section Abstract Doc Link 18412380 Disease Relevance 0 Pain Relevance 0.80

Coenzyme Q10 has also been found to exert effects on ?

Coenzyme Q10 Binding (found) of

9) Confidence 0.31 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2785862 Disease Relevance 1.67 Pain Relevance 0.05

Moreover, an assay of NADH to cytochrome-c reductase activity showed a significant increase in the patients treated with 1,200 mg CoQ10.78

CoQ10 Binding (1,200) of

10) Confidence 0.31 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2785862 Disease Relevance 0.11 Pain Relevance 0

Thus we confirmed the physical interaction between GM1 and A?

GM1 Binding (interaction) of

11) Confidence 0.30 Published 2010 Journal ASN NEURO Section Body Doc Link PMC2838405 Disease Relevance 0.24 Pain Relevance 0

As well, in NECs treated with GM1 and/or A?

GM1 Binding (/) of

12) Confidence 0.30 Published 2010 Journal ASN NEURO Section Body Doc Link PMC2838405 Disease Relevance 0.62 Pain Relevance 0.05

GM1 binding assay

GM1 Binding (binding) of

13) Confidence 0.30 Published 2010 Journal ASN NEURO Section Body Doc Link PMC2838405 Disease Relevance 0.07 Pain Relevance 0

The NECs treated with GM1 and/or A?

GM1 Binding (/) of

14) Confidence 0.30 Published 2010 Journal ASN NEURO Section Body Doc Link PMC2838405 Disease Relevance 0.08 Pain Relevance 0.08

As shown in Figure 8(A), this assay could dose-dependently detect binding of Ctxb to GM1 immobilized on 96-well plates.

GM1 Binding (binding) of

15) Confidence 0.30 Published 2010 Journal ASN NEURO Section Body Doc Link PMC2838405 Disease Relevance 0.11 Pain Relevance 0

In NECs treated with GM1 and/or A?

GM1 Binding (/) of

16) Confidence 0.30 Published 2010 Journal ASN NEURO Section Body Doc Link PMC2838405 Disease Relevance 0 Pain Relevance 0

In NSCs treated with GM1 and/or A?

GM1 Binding (/) of

17) Confidence 0.30 Published 2010 Journal ASN NEURO Section Body Doc Link PMC2838405 Disease Relevance 0.10 Pain Relevance 0.03

Physical interaction between GM1 and A?

GM1 Binding (interaction) of

18) Confidence 0.30 Published 2010 Journal ASN NEURO Section Body Doc Link PMC2838405 Disease Relevance 0.07 Pain Relevance 0

These results indicate that GM1 and 10 ?

GM1 Binding (indicate) of

19) Confidence 0.30 Published 2010 Journal ASN NEURO Section Body Doc Link PMC2838405 Disease Relevance 0.14 Pain Relevance 0

It was confirmed that a number of NECs treated with GM1 and A?

GM1 Binding (treated) of

20) Confidence 0.30 Published 2010 Journal ASN NEURO Section Body Doc Link PMC2838405 Disease Relevance 0.63 Pain Relevance 0.04

General Comments

This test has worked.