INT6067

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Context Info
Confidence 0.69
First Reported 1984
Last Reported 2010
Negated 1
Speculated 3
Reported most in Abstract
Documents 37
Total Number 40
Disease Relevance 6.56
Pain Relevance 36.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Oprd1) cytoplasm (Oprd1) signal transducer activity (Oprd1)
Anatomy Link Frequency
medulla 3
spinal cord 2
spike 2
brain 2
dorsal horn 2
Oprd1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 182 100.00 Very High Very High Very High
Morphine 148 100.00 Very High Very High Very High
agonist 71 100.00 Very High Very High Very High
Opioid 62 100.00 Very High Very High Very High
Enkephalin 59 100.00 Very High Very High Very High
narcan 28 100.00 Very High Very High Very High
medulla 22 100.00 Very High Very High Very High
Spinal cord 16 100.00 Very High Very High Very High
Delta opioid receptors 15 100.00 Very High Very High Very High
adenocard 15 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 23 100.00 Very High Very High Very High
Hyperalgesia 4 99.98 Very High Very High Very High
INFLAMMATION 16 99.64 Very High Very High Very High
Pheochromocytoma 6 99.48 Very High Very High Very High
Appetite Loss 4 99.44 Very High Very High Very High
Cv Unclassified Under Development 3 99.12 Very High Very High Very High
Injury 11 99.08 Very High Very High Very High
Pain 72 99.00 Very High Very High Very High
Parkinson's Disease 3 98.08 Very High Very High Very High
Disease 11 97.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
NGF treatment of PC12h cells also results in the induction of delta opioid receptor (DOR-1) mRNA.
Positive_regulation (results) of Positive_regulation (induction) of delta opioid receptor associated with nerve growth factor and opioid receptor
1) Confidence 0.69 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7562535 Disease Relevance 0.16 Pain Relevance 0.60
NGF treatment of PC12h cells also results in the induction of delta opioid receptor (DOR-1) mRNA.
Positive_regulation (results) of Positive_regulation (induction) of DOR-1 associated with nerve growth factor and opioid receptor
2) Confidence 0.49 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7562535 Disease Relevance 0.16 Pain Relevance 0.61
The results show that opioid receptor activation in the LPBN induces hypertonic sodium intake in satiated and normohydrated rats, an effect not due to general ingestive behavior facilitation.
Positive_regulation (induces) of Positive_regulation (activation) of opioid receptor in LPBN associated with opioid receptor
3) Confidence 0.49 Published 2008 Journal Neuroscience Section Abstract Doc Link 18602454 Disease Relevance 0 Pain Relevance 0.52
These results provide evidence that naltrex-one-induced upregulation of the opioid receptor complex might occur indirectly as a consequence of interactions at beta-funaltrexamine-insensitive opioid receptors and that morphine-induced upregulation (increased Bmax) of the opioid receptor complex is a relevant in vitro marker related to the development of tolerance and dependence.
Positive_regulation (naltrex-one-induced) of Positive_regulation (upregulation) of opioid receptor associated with addiction, tolerance, opioid receptor and morphine
4) Confidence 0.48 Published 1991 Journal Peptides Section Abstract Doc Link 1646998 Disease Relevance 0 Pain Relevance 1.49
These results provide evidence that naltrex-one-induced upregulation of the opioid receptor complex might occur indirectly as a consequence of interactions at beta-funaltrexamine-insensitive opioid receptors and that morphine-induced upregulation (increased Bmax) of the opioid receptor complex is a relevant in vitro marker related to the development of tolerance and dependence.
Positive_regulation (morphine-induced) of Positive_regulation (upregulation) of opioid receptor associated with addiction, tolerance, opioid receptor and morphine
5) Confidence 0.48 Published 1991 Journal Peptides Section Abstract Doc Link 1646998 Disease Relevance 0 Pain Relevance 1.36
These results provide evidence that naltrex-one-induced upregulation of the opioid receptor complex might occur indirectly as a consequence of interactions at beta-funaltrexamine-insensitive opioid receptors and that morphine-induced upregulation (increased Bmax) of the opioid receptor complex is a relevant in vitro marker related to the development of tolerance and dependence.
Positive_regulation (increased) of Positive_regulation (upregulation) of opioid receptor associated with addiction, tolerance, opioid receptor and morphine
6) Confidence 0.48 Published 1991 Journal Peptides Section Abstract Doc Link 1646998 Disease Relevance 0 Pain Relevance 1.35
Both peptides concentration dependently (1 nM-1 microM) inhibited the release of radiolabeled acetylcholine (ACh) from striatal slices (pD2 7.6-7.9), an effect exclusively mediated by delta-opioid receptor activation.
Positive_regulation (mediated) of Positive_regulation (activation) of delta-opioid receptor associated with opioid receptor
7) Confidence 0.48 Published 1989 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2575993 Disease Relevance 0 Pain Relevance 0.68
Therefore, the purpose of the present study was to test the hypothesis that ischemia- and morphine-induced cardioprotection are mediated via stimulation of the delta-opioid receptor in the rat heart.
Positive_regulation (mediated) of Positive_regulation (stimulation) of delta-opioid receptor in heart associated with ischemia, opioid receptor and morphine
8) Confidence 0.46 Published 1997 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 9281450 Disease Relevance 0.26 Pain Relevance 0.95
Although it is still unclear about the cellular and molecular mechanisms of morphine analgesia, evidence supported that morphine-induced opioid-receptor activation results in the enhancement of phosphorylation of mitogen-activated protein kinase (MAPK) in ACC, SI and locus ceruleus [38].
Positive_regulation (induced) of Positive_regulation (activation) of opioid-receptor associated with primary somatosensory cortex, locus ceruleus, anterior cingulate cortex, opioid, analgesia and morphine
9) Confidence 0.45 Published 2009 Journal Mol Pain Section Body Doc Link PMC2770513 Disease Relevance 0.86 Pain Relevance 2.45
On the contrary, activation of both mu- or delta-opioid receptors in the ventral tegmental area significantly increased self-stimulation and decreased spontaneous motor activity, supporting the view that different mechanisms underlie the behavioural effects, resulting from enhancement of endogenous enkephalins and from activation of specific opioid receptors in the ventral mesencephalon.
Positive_regulation (increased) of Positive_regulation (activation) of delta-opioid in mesencephalon associated with ventral tegmentum, opioid receptor, enkephalin and delta opioid receptors
10) Confidence 0.44 Published 1992 Journal Neuropharmacology Section Abstract Doc Link 1321359 Disease Relevance 0 Pain Relevance 0.96
The antihyperalgesic potency of the mu opioid receptor agonist [D-Ala(2),N-Me-Phe(4),Gly(5)-ol]enkephalin (DAMGO), determined for the inflamed hindpaw, was enhanced 4 d and 2 weeks after injury.
Positive_regulation (enhanced) of Spec (determined) Positive_regulation (potency) of opioid receptor associated with antihyperalgesic, injury, agonist, mu opioid receptor, enkephalin and potency
11) Confidence 0.43 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 10648729 Disease Relevance 0.85 Pain Relevance 1.09
Furthermore, both DSTBULET and BUBU caused a strong inhibition (pD2 8.2-8.3) of D-1 dopamine receptor-stimulated cyclic AMP efflux from striatal slices, an effect known to be mediated by mu- and/or delta-opioid receptor activation.
Positive_regulation (mediated) of Positive_regulation (activation) of delta-opioid receptor associated with dopamine receptor and opioid receptor
12) Confidence 0.42 Published 1989 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2575993 Disease Relevance 0 Pain Relevance 0.82
The interactions between dopamine receptors and opioid receptors coupled to adenylate cyclase in rat neostriatum were investigated. cAMP efflux from neostriatal slices induced by simultaneous activation of (stimulatory) D-1 and (inhibitory) D-2 dopamine receptors with 30 microM dopamine was inhibited by the preferential delta-opioid receptor agonist [D-Ala2-D-Leu5] enkephalin (DADLE) and the mu-opioid receptor agonist morphine with an EC50 of 100 and 800 nM, respectively.
Positive_regulation (induced) of Positive_regulation (activation) of D-1 associated with dopamine, dopamine receptor, agonist, enkephalin, opioid receptor and morphine
13) Confidence 0.37 Published 1986 Journal J. Neurosci. Section Abstract Doc Link 3018189 Disease Relevance 0 Pain Relevance 0.94
Inflammation and hyperalgesia induce a dramatic up-regulation of opioid messenger RNA and peptide levels in nociceptive neurons of the spinal dorsal horn.
Positive_regulation (induce) of Positive_regulation (up-regulation) of opioid messenger RNA in dorsal horn associated with nociception, hyperalgesia, inflammation, spinal dorsal horn and opioid
14) Confidence 0.36 Published 1999 Journal Neuroscience Section Abstract Doc Link 10197770 Disease Relevance 0.97 Pain Relevance 0.85
This finding is contradictory to the generally held view that antagonist-induced opioid receptor up-regulation in brain increases asymptotically, leveling off after a relatively brief treatment period.
Positive_regulation (induced) of Positive_regulation (up-regulation) of opioid receptor in brain associated with antagonist and opioid receptor
15) Confidence 0.36 Published 1990 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2173747 Disease Relevance 0 Pain Relevance 0.32
These results clearly indicate that activation of the mu opioid receptor increases the number of spike-wave discharges, and that modulation of delta receptors is not effective.
Positive_regulation (increases) of Positive_regulation (activation) of opioid receptor in spike associated with mu opioid receptor
16) Confidence 0.35 Published 1994 Journal Neuropharmacology Section Abstract Doc Link 8035901 Disease Relevance 0.34 Pain Relevance 0.56
PERSPECTIVE: Although the role of adenosine release in the spinal cord for opioid receptor activation in subsequent analgesia from opioids is controversial in laboratory studies, these clinical data suggest that local opioid receptor stimulation in the spinal cord of humans does release adenosine.
Positive_regulation (role) of Positive_regulation (activation) of opioid receptor in spinal cord associated with adenocard, opioid receptor, opioid, analgesia and spinal cord
17) Confidence 0.34 Published 2004 Journal J Pain Section Abstract Doc Link 14975380 Disease Relevance 0 Pain Relevance 2.51
An alternative hypothesis is that opioid receptors remain operative following repeated opiate administration but that opioid receptor activation rapidly induces a prolonged increase in pain sensitivity which opposes the predominant opiate analgesic effect following repeated opiate administration.
Positive_regulation (induces) of Positive_regulation (activation) of opioid receptor associated with pain, analgesic, opiate and opioid receptor
18) Confidence 0.29 Published 1999 Journal Neuroscience Section Abstract Doc Link 10199599 Disease Relevance 0.37 Pain Relevance 1.54
Chronic fentanyl treatments induce the up-regulation of mu opioid receptor mRNA in rat pheochromocytoma cells.
Positive_regulation (induce) of Positive_regulation (induce) of opioid receptor associated with mu opioid receptor and pheochromocytoma
19) Confidence 0.21 Published 2000 Journal Brain Res. Section Title Doc Link 10719067 Disease Relevance 0.18 Pain Relevance 0.64
These results indicate that vasodilator responses to TAPP and endomorphin 2 are mediated by the activation of a naloxone-sensitive opioid receptor and the release of nitric oxide from the endothelium within the hindquarter vascular bed of the rat.
Positive_regulation (mediated) of Positive_regulation (activation) of opioid receptor in endothelium associated with narcan and opioid receptor
20) Confidence 0.21 Published 1998 Journal Am. J. Physiol. Section Abstract Doc Link 9612381 Disease Relevance 0.06 Pain Relevance 0.36

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