INT60683

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Context Info
Confidence 0.07
First Reported 1995
Last Reported 2010
Negated 2
Speculated 1
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 1.53
Pain Relevance 1.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (VIPR1) plasma membrane (VIPR1) nucleus (VIPR1)
cytoplasm (VIPR1) signal transducer activity (VIPR1)
VIPR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 2 99.98 Very High Very High Very High
antagonist 2 99.16 Very High Very High Very High
alcohol 3 96.80 Very High Very High Very High
dopamine receptor 1 95.84 Very High Very High Very High
qutenza 6 93.80 High High
Central nervous system 6 91.12 High High
agonist 3 88.00 High High
medulla 1 82.52 Quite High
Raphe 2 75.60 Quite High
imagery 3 75.00 Quite High
Disease Link Frequency Relevance Heat
Hypoxia 39 95.76 Very High Very High Very High
Hypocapnia 4 70.64 Quite High
Alkalosis 3 69.44 Quite High
Acid Base Imbalance 2 50.00 Quite Low
Pressure And Volume Under Development 22 46.20 Quite Low
Heart Rate Under Development 12 37.04 Quite Low
Depression 1 36.72 Quite Low
Injury 1 35.68 Quite Low
Stroke 2 7.76 Low Low
Altitude Sickness 65 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study, we sought to determine whether the central or peripheral activity of endogenous dopamine modulates this decreased HVR.
Spec (whether) Regulation (modulates) of HVR associated with dopamine
1) Confidence 0.07 Published 1995 Journal Respir Physiol Section Abstract Doc Link 8525121 Disease Relevance 0.90 Pain Relevance 0.30
Compared to rVR1, hVR1 was more sensitive to blockade by both antagonists.
Regulation (sensitive) of hVR1 associated with antagonist
2) Confidence 0.04 Published 2002 Journal J Biomol Screen Section Abstract Doc Link 14599363 Disease Relevance 0 Pain Relevance 0.62
Physical conditioning apparently has no effect on the HVR.
Neg (no) Regulation (effect) of HVR
3) Confidence 0.04 Published 2010 Journal Indian Journal of Occupational and Environmental Medicine Section Body Doc Link PMC2923424 Disease Relevance 0.40 Pain Relevance 0.09
However, systemic DAMGO-induced HVR attenuation was not significantly affected by pretreating the cMRR and mMRR with CTAP.
Neg (not) Regulation (affected) of HVR
4) Confidence 0.01 Published 2009 Journal Respir Physiol Neurobiol Section Abstract Doc Link 19632358 Disease Relevance 0.23 Pain Relevance 0.26

General Comments

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