INT60690

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Context Info
Confidence 0.63
First Reported 1995
Last Reported 2011
Negated 1
Speculated 5
Reported most in Abstract
Documents 69
Total Number 76
Disease Relevance 41.41
Pain Relevance 20.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il12a) extracellular region (Il12a) cytoplasm (Il12a)
Anatomy Link Frequency
macrophages 29
T cells 10
Th1 cell 6
nucleus 6
dendritic cells 5
Il12a (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 1488 100.00 Very High Very High Very High
Inflammation 1056 100.00 Very High Very High Very High
agonist 227 100.00 Very High Very High Very High
rheumatoid arthritis 127 100.00 Very High Very High Very High
Morphine 42 99.98 Very High Very High Very High
withdrawal 56 99.84 Very High Very High Very High
Peripheral nervous system 9 99.76 Very High Very High Very High
antagonist 109 99.36 Very High Very High Very High
Clonidine 7 99.08 Very High Very High Very High
psoriasis 132 98.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Infection 2511 100.00 Very High Very High Very High
Cold Sores 1930 100.00 Very High Very High Very High
INFLAMMATION 1148 100.00 Very High Very High Very High
Rheumatoid Arthritis 135 100.00 Very High Very High Very High
Cancer 623 99.92 Very High Very High Very High
Autoimmune Disease 83 99.92 Very High Very High Very High
Targeted Disruption 295 99.88 Very High Very High Very High
Cryptococcus Infection 22 99.76 Very High Very High Very High
Necrosis 105 99.68 Very High Very High Very High
Psoriasis 169 98.98 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Stimulation of interleukin-12 production in mouse macrophages via activation of p38 mitogen-activated protein kinase by alpha2-adrenoceptor agonists.
Positive_regulation (Stimulation) of Gene_expression (production) of interleukin-12 in macrophages associated with agonist
1) Confidence 0.63 Published 2003 Journal Eur. J. Pharmacol. Section Title Doc Link 12706479 Disease Relevance 0 Pain Relevance 0.41
Morphine enhances interleukin-12 and the production of other pro-inflammatory cytokines in mouse peritoneal macrophages.
Positive_regulation (enhances) of Gene_expression (production) of interleukin-12 in peritoneal macrophages associated with inflammation, cytokine and morphine
2) Confidence 0.60 Published 2000 Journal J. Leukoc. Biol. Section Title Doc Link 11073113 Disease Relevance 0.23 Pain Relevance 0.83
IL-12 SJL transgenic mice were made by expressing IL-12 p70 under the transcriptional control of the thyroglobulin promoter, resulting in IL-12 overexpression in the thyroid organ [69].
Positive_regulation (overexpression) of Gene_expression (overexpression) of IL-12 in thyroid associated with targeted disruption
3) Confidence 0.51 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3018660 Disease Relevance 0.75 Pain Relevance 0.07
Sex-dependent growth retardation was observed in female, but not male mice, suggesting a sex-specific effect of IL-12 overexpression [70].
Positive_regulation (overexpression) of Gene_expression (overexpression) of IL-12
4) Confidence 0.51 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3018660 Disease Relevance 0.60 Pain Relevance 0.03
IL-12 SJL transgenic mice were made by expressing IL-12 p70 under the transcriptional control of the thyroglobulin promoter, resulting in IL-12 overexpression in the thyroid organ [69].
Positive_regulation (resulting) of Gene_expression (overexpression) of IL-12 in thyroid associated with targeted disruption
5) Confidence 0.51 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3018660 Disease Relevance 0.75 Pain Relevance 0.07
As administration of interleukin 12 and indomethacin resulted in enhanced inhibition of angiogenesis it seems possible that prevention of new blood vessel formation is one of the mechanisms responsible for the observed antitumor effects.
Positive_regulation (administration) of Gene_expression (administration) of interleukin 12 in blood vessel
6) Confidence 0.50 Published 2000 Journal Life Sci. Section Abstract Doc Link 10737417 Disease Relevance 0.47 Pain Relevance 0.15
This study was designed to determine if alpha(2)-adrenoceptor agonists are involved in the induction of interleukin-12 production by macrophages. alpha(2)-adrenoceptor agonists such as clonidine, guanfacine, and oxymetazoline significantly induced interleukin-12 secretion and interleukin-12 mRNA expression by macrophages in a concentration-dependent manner.
Positive_regulation (induced) of Gene_expression (expression) of interleukin-12 in macrophages associated with agonist and clonidine
7) Confidence 0.46 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12706479 Disease Relevance 0 Pain Relevance 0.45
This study was designed to determine if alpha(2)-adrenoceptor agonists are involved in the induction of interleukin-12 production by macrophages. alpha(2)-adrenoceptor agonists such as clonidine, guanfacine, and oxymetazoline significantly induced interleukin-12 secretion and interleukin-12 mRNA expression by macrophages in a concentration-dependent manner.
Positive_regulation (induction) of Gene_expression (production) of interleukin-12 in macrophages associated with agonist and clonidine
8) Confidence 0.46 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12706479 Disease Relevance 0 Pain Relevance 0.37
Stimulation of interleukin-12 production in mouse macrophages via activation of p38 mitogen-activated protein kinase by alpha2-adrenoceptor agonists.
Positive_regulation (activation) of Gene_expression (production) of interleukin-12 in macrophages associated with agonist
9) Confidence 0.46 Published 2003 Journal Eur. J. Pharmacol. Section Title Doc Link 12706479 Disease Relevance 0 Pain Relevance 0.44
This study was designed to determine if alpha(2)-adrenoceptor agonists are involved in the induction of interleukin-12 production by macrophages. alpha(2)-adrenoceptor agonists such as clonidine, guanfacine, and oxymetazoline significantly induced interleukin-12 secretion and interleukin-12 mRNA expression by macrophages in a concentration-dependent manner.
Positive_regulation (induced) of Gene_expression (expression) of interleukin-12 in macrophages associated with agonist and clonidine
10) Confidence 0.46 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12706479 Disease Relevance 0 Pain Relevance 0.45
Additional studies are being performed which address whether PTU treatment of patients with plaque psoriasis leads to reduced in situ IL-12 expression, alters production of the IL-35 or IL-40 components of the IL-70 heterodimer, as well as exerts an effect by enhancing apoptosis in the proliferated keratinocytes that make up the psoriatic plaque which would result in clinical improvement.


Positive_regulation (components) of Gene_expression (production) of IL-35 in keratinocytes associated with psoriasis and apoptosis
11) Confidence 0.44 Published 2003 Journal BMC Dermatol Section Body Doc Link PMC169161 Disease Relevance 0.53 Pain Relevance 0.21
In addition, protein kinase C (PKC) inhibitors, 1-(5-isoquinolinesulfonyl)-2-methylpiperazine dihydrochloride (H-7) and chelerythrine, significantly inhibited guanfacine-induced interleukin-12 production and p38 MAPK in a concentration-dependent manner.
Positive_regulation (induced) of Gene_expression (production) of interleukin-12 associated with kinase c
12) Confidence 0.43 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12706479 Disease Relevance 0 Pain Relevance 0.60
Yohimbine and 2-(2,3-dihydro-2-methoxy-1,4-benzodioxin-2-yl)4,5-dihydro-1H-imidazole (RX821002), alpha(2)-adrenoceptor antagonists, significantly blocked agonist-induced interleukin-12 production and p38 MAPK activation, indicating that the effects of the agonists were mediated through alpha(2)-adrenoceptor.
Positive_regulation (induced) of Gene_expression (production) of interleukin-12 associated with antagonist and agonist
13) Confidence 0.43 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12706479 Disease Relevance 0 Pain Relevance 0.63
Supernatants were examined for IL-2, IL-4, IL-10, IL-12, and IFNgamma cytokine production using cytokine specific ELISAs.
Spec (examined) Positive_regulation (examined) of Gene_expression (production) of IL-12 associated with cytokine
14) Confidence 0.37 Published 1999 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 10606002 Disease Relevance 0.71 Pain Relevance 0.79
Transcription of the IL-12p40 gene in macrophages requires de novo protein synthesis during the inducing HSV infection, which could explain the relatively late appearance of IL-12 production [238,367].
Positive_regulation (appearance) of Gene_expression (production) of IL-12 in macrophages associated with cold sores and infection
15) Confidence 0.36 Published 2005 Journal Virol J Section Body Doc Link PMC1215526 Disease Relevance 1.09 Pain Relevance 0.07
This is in line with the requirement of infectious HSV for IL-12 production and thus for production of IFN-?
Positive_regulation (requirement) of Gene_expression (production) of IL-12 associated with cold sores
16) Confidence 0.36 Published 2005 Journal Virol J Section Body Doc Link PMC1215526 Disease Relevance 1.20 Pain Relevance 0
B is of significance in HSV-induced IL-12 production.
Positive_regulation (induced) of Gene_expression (production) of IL-12 associated with cold sores
17) Confidence 0.36 Published 2005 Journal Virol J Section Body Doc Link PMC1215526 Disease Relevance 0.84 Pain Relevance 0.06
Protein kinase A activation then prevents the phosphorylation and subsequent degradation of IkappaB, which in turn prevents translocation of the NF-kappaB p65 subunit to the nucleus to transactivate the IL-12 p40 gene, ultimately resulting in decreased IL-12 production following LPS stimulation.
Positive_regulation (following) of Gene_expression (production) of IL-12 in nucleus
18) Confidence 0.32 Published 2008 Journal J. Immunol. Section Abstract Doc Link 18322172 Disease Relevance 0 Pain Relevance 0.75
Protein kinase A activation then prevents the phosphorylation and subsequent degradation of IkappaB, which in turn prevents translocation of the NF-kappaB p65 subunit to the nucleus to transactivate the IL-12 p40 gene, ultimately resulting in decreased IL-12 production following LPS stimulation.
Positive_regulation (resulting) of Gene_expression (production) of IL-12 in nucleus
19) Confidence 0.32 Published 2008 Journal J. Immunol. Section Abstract Doc Link 18322172 Disease Relevance 0 Pain Relevance 0.76
At 24 hr, a massive neutrophil recruitment and an induced expression of a wide spectrum of murine cytokine mRNA (i.e., interleukin [IL]-1 beta, IL-4, IL-6, IL-10, IL-12, tumor necrosis factor [TNF]-alpha and interferon [IFN]-gamma) occurred in the huPBL-SCID mouse peritoneal cavity.
Positive_regulation (induced) of Gene_expression (expression) of IL-12 in peritoneal cavity associated with necrosis, cancer, severe combined immunodeficiency and cytokine
20) Confidence 0.31 Published 1995 Journal Transplantation Section Abstract Doc Link 8525526 Disease Relevance 0.70 Pain Relevance 0.13

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