INT60694

Context Info Confidence 0.78 First Reported 1995 Last Reported 2011 Negated 14 Speculated 15 Reported most in Abstract Documents 567 Total Number 584 Disease Relevance 369.48 Pain Relevance 143.69

extracellular space (Il10) extracellular region (Il10) intracellular (Il10)

Anatomy Link Frequency T cells 53 macrophages 28 lung 15 Kupffer cells 11 monocytes 10 Il10 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 9816 100.00 cytokine 9772 100.00 chemokine 823 100.00 antagonist 363 100.00 Dismenorea 12 100.00 Spinal cord 853 99.98 Inflammatory mediators 416 99.96 Arthritis 855 99.84 Opioid 17 99.84 methotrexate 239 99.78

Disease Link Frequency Relevance Heat INFLAMMATION 10626 100.00 Cancer 3804 100.00 Targeted Disruption 2368 100.00 Fibrosis 1670 100.00 Necrosis 682 100.00 Dysmenorrhea 10 100.00 Epstein-barr Virus 608 99.92 Arthritis 849 99.84 Diabetes Mellitus 675 99.84 Atherosclerosis 215 99.82

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Our aim was to investigate the role of adrenoceptors in the modulation of in vivo interleukin-10 (IL-10) production in lipopolysaccharide (LPS)-treated mice.

Gene_expression (production) of interleukin-10

1) Confidence 0.78 Published 2000 Journal Neuroreport Section Abstract Doc Link 11095519 Disease Relevance 0 Pain Relevance 0.20

Our aim was to investigate the role of adrenoceptors in the modulation of in vivo interleukin-10 (IL-10) production in lipopolysaccharide (LPS)-treated mice.

Gene_expression (production) of IL-10

2) Confidence 0.78 Published 2000 Journal Neuroreport Section Abstract Doc Link 11095519 Disease Relevance 0 Pain Relevance 0.20

Our results provide the first in vivo evidence that, in addition to beta-adrenoceptors; alpha-adrenoceptors play also a very important role in the regulation of IL-10 production under endotoxaemic conditions.

Gene_expression (production) of IL-10

3) Confidence 0.78 Published 2000 Journal Neuroreport Section Abstract Doc Link 11095519 Disease Relevance 0 Pain Relevance 0.26

Our results confirmed the involvement of beta-adrenoceptors since the beta-agonist isoproterenol significantly increased the IL-10 production in response to LPS stimulation, whereas the beta-antagonists propranolol decreased it.

Gene_expression (production) of IL-10 associated with antagonist and agonist

4) Confidence 0.78 Published 2000 Journal Neuroreport Section Abstract Doc Link 11095519 Disease Relevance 0 Pain Relevance 0.27

Opposite role of alpha2- and beta-adrenoceptors in the modulation of interleukin-10 production in endotoxaemic mice.

Gene_expression (production) of interleukin-10

5) Confidence 0.78 Published 2000 Journal Neuroreport Section Title Doc Link 11095519 Disease Relevance 0 Pain Relevance 0.23

Therefore, the absence of IL-10 expression accelerates the kinetics of lesion expansion, the onset of pain behaviors, and the peripheral immune response to spinal cord injury.

Gene_expression (expression) of IL-10 in spinal cord associated with pain and spinal cord

6) Confidence 0.78 Published 2004 Journal Neuroscience Section Abstract Doc Link 15026134 Disease Relevance 1.22 Pain Relevance 0.63

However, the role of endogenous production of IL-10 has not been considered.

Gene_expression (production) of IL-10

7) Confidence 0.78 Published 2004 Journal Neuroscience Section Abstract Doc Link 15026134 Disease Relevance 0.72 Pain Relevance 0.36

OBJECTIVE: To investigate the expression of interleukin-10 (IL-10) in adenomyosis.

Spec (investigate) Gene_expression (expression) of interleukin-10 associated with dismenorea

8) Confidence 0.78 Published 2009 Journal Fertil. Steril. Section Abstract Doc Link 18439592 Disease Relevance 0.17 Pain Relevance 0.17

Expression of interleukin-10 in patients with adenomyosis.

Gene_expression (Expression) of interleukin-10 associated with dismenorea

9) Confidence 0.78 Published 2009 Journal Fertil. Steril. Section Title Doc Link 18439592 Disease Relevance 0.10 Pain Relevance 0.20

OBJECTIVE: To investigate the expression of interleukin-10 (IL-10) in adenomyosis.

Spec (investigate) Gene_expression (expression) of IL-10 associated with dismenorea

10) Confidence 0.78 Published 2009 Journal Fertil. Steril. Section Abstract Doc Link 18439592 Disease Relevance 0.17 Pain Relevance 0.17

MAIN OUTCOME MEASURE(S): Microscopic evaluation to assess the presence and localization of IL-10 throughout the menstrual cycle in both eutopic endometrial and adenomyotic tissues of women with adenomyosis and compare it with IL-10 expression in the normal endometrium.

Gene_expression (expression) of IL-10 in endometrium

11) Confidence 0.78 Published 2009 Journal Fertil. Steril. Section Body Doc Link 18439592 Disease Relevance 0.08 Pain Relevance 0

Some IL-10 was produced but only from non-T cells.

Gene_expression (produced) of IL-10 in T cells

12) Confidence 0.78 Published 2004 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 15246967 Disease Relevance 0.62 Pain Relevance 0.34

Epstein-Barr virus (EBV) takes advantage of the immunomodulatory effects of IL-10 by expressing a viral homolog of IL-10 during infections [6].

Gene_expression (expressing) of IL-10 associated with epstein-barr virus and infection

13) Confidence 0.78 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2749443 Disease Relevance 0.75 Pain Relevance 0.11

We found that CD4+ T cells produce a significant amount of IL-10 and may be a major cellular source of IL-10 in vivo during WNV infection.

Gene_expression (produce) of IL-10 in T cells associated with infection

14) Confidence 0.78 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2749443 Disease Relevance 0.54 Pain Relevance 0

Our data also indicate that macrophages produce IL-10 when exposed to WNV ex vivo (Figure 1 A and B), which is consistent with in vivo results showing that CD11b+ macrophages produce low levels of IL-10.

Gene_expression (produce) of IL-10 in macrophages

15) Confidence 0.78 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2749443 Disease Relevance 0.39 Pain Relevance 0

Our data also indicate that macrophages produce IL-10 when exposed to WNV ex vivo (Figure 1 A and B), which is consistent with in vivo results showing that CD11b+ macrophages produce low levels of IL-10.

Gene_expression (produce) of IL-10 in macrophages

16) Confidence 0.78 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2749443 Disease Relevance 0.44 Pain Relevance 0

However, excessive IL-10 production suppresses host immune responses and can inadvertently facilitate the ability of intracellular pathogens to escape host innate immune defenses.

Gene_expression (production) of IL-10

17) Confidence 0.78 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2749443 Disease Relevance 0.73 Pain Relevance 0.09

In addition, recent studies showed that lymphocytic choriomeningitis virus (LCMV) clone 13 elicits high levels of IL-10 production from the infected host, thereby resulting in exhaustion of virus-specific T cells and viral persistence [7]–[9].

Gene_expression (production) of IL-10 in T cells associated with lymphocytic choriomeningitis

18) Confidence 0.78 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2749443 Disease Relevance 0.67 Pain Relevance 0.11

Intrapancreatic IL-10 gene expression was assessed by semiquantitative RT-PCR, and intrapancreatic collagen content was assessed by picrosirius staining.

Gene_expression (expression) of IL-10 gene

19) Confidence 0.76 Published 2002 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 12016137 Disease Relevance 1.08 Pain Relevance 0.30

Finally, two independent reports have demonstrated that blockade of the IL-10 receptor during chronic lymphocytic choriomeningitis virus infection led to clearance of the infection with enhanced IL-10 production by dendritic cells [63],[64].

Gene_expression (production) of IL-10 in dendritic cells associated with lymphocytic choriomeningitis and infection

20) Confidence 0.76 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2270344 Disease Relevance 0.88 Pain Relevance 0.12

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