INT60711

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Context Info
Confidence 0.36
First Reported 1995
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.91
Pain Relevance 1.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Col7a1) cell adhesion (Col7a1) proteinaceous extracellular matrix (Col7a1)
Anatomy Link Frequency
heart 2
Col7a1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 18 99.96 Very High Very High Very High
Arthritis 42 99.64 Very High Very High Very High
Kinase C 225 98.00 Very High Very High Very High
Inflammation 37 92.68 High High
Snapping jaw 1 75.00 Quite High
chemokine 6 74.80 Quite High
cytokine 31 74.20 Quite High
Inflammatory response 6 54.76 Quite High
ischemia 7 45.72 Quite Low
rheumatoid arthritis 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Thrombosis 39 100.00 Very High Very High Very High
Hypertrophy 3 99.70 Very High Very High Very High
Arthritis 42 99.64 Very High Very High Very High
Stress 3 98.24 Very High Very High Very High
Diabetes Mellitus 16 95.16 Very High Very High Very High
Heart Rate Under Development 10 94.24 High High
INFLAMMATION 44 92.68 High High
Hypertension 7 90.64 High High
Sudden Death 3 86.96 High High
Arrhythmia Under Development 1 86.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunohistochemical staining with anti-type VI collagen antibody was strongly positive in the intimal layer and moderately positive in the subsynovium.
Negative_regulation (positive) of collagen Binding (staining) of
1) Confidence 0.36 Published 1995 Journal Arch. Oral Biol. Section Abstract Doc Link 8526809 Disease Relevance 0.07 Pain Relevance 0.07
THR0921, a novel peroxisome proliferator-activated receptor gamma agonist, reduces the severity of collagen-induced arthritis

THR0921 is a novel peroxisome proliferator-activated receptor gamma (PPAR?)

Negative_regulation (reduces) of collagen Binding (severity) of associated with agonist and arthritis
2) Confidence 0.03 Published 2006 Journal Arthritis Res Ther Section Title Doc Link PMC1526548 Disease Relevance 0.75 Pain Relevance 0.33
We conclude that all four major expressed PKC isoforms play distinct non-redundant roles, where the conventional PKCs promote and the novel PKCs inhibit thrombus formation on collagen, by a variety of mechanisms (summarized in Fig. 8C).
Negative_regulation (inhibit) of collagen Neg (inhibit) Binding (formation) of associated with kinase c and thrombosis
3) Confidence 0.03 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2906332 Disease Relevance 0.45 Pain Relevance 0.50
However, progressive LV hypertrophy combined with loss of collagen crosslinking and myocyte slippage causes increased wall stress leading to cardiac chamber dilatation, contractile dysfunction, and ultimately decompensated congestive heart failure (CHF) [69].
Negative_regulation (loss) of collagen Binding (crosslinking) of in heart associated with stress, heart rate under development and hypertrophy
4) Confidence 0.01 Published 2010 Journal PPAR Research Section Body Doc Link PMC2931381 Disease Relevance 1.64 Pain Relevance 0.14

General Comments

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