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Context Info
Confidence 0.43
First Reported 1995
Last Reported 2010
Negated 1
Speculated 5
Reported most in Body
Documents 47
Total Number 52
Disease Relevance 22.52
Pain Relevance 6.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Col7a1) cell adhesion (Col7a1) proteinaceous extracellular matrix (Col7a1)
Anatomy Link Frequency
inferior 4
extracellular matrix 4
lung 3
stroma 2
fibroblasts 2
Col7a1 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 265 100.00 Very High Very High Very High
agonist 24 99.72 Very High Very High Very High
Arthritis 179 99.64 Very High Very High Very High
Inflammatory response 47 99.12 Very High Very High Very High
Kinase C 675 98.44 Very High Very High Very High
Inflammation 467 97.12 Very High Very High Very High
anesthesia 25 96.16 Very High Very High Very High
fibrosis 172 93.76 High High
halothane 11 93.56 High High
alcohol 4 87.40 High High
Disease Link Frequency Relevance Heat
Thrombosis 115 100.00 Very High Very High Very High
Arthritis 196 99.64 Very High Very High Very High
Hypertrophy 6 99.54 Very High Very High Very High
INFLAMMATION 521 99.12 Very High Very High Very High
Aging 389 99.04 Very High Very High Very High
Congenital Anomalies 47 98.96 Very High Very High Very High
Adhesions 94 98.58 Very High Very High Very High
Injury 80 98.36 Very High Very High Very High
Stress 91 98.24 Very High Very High Very High
Systemic Sclerosis 87 98.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Collagen, expressed per weight of tissue, was significantly increased in all tissues from high-growth mice, as was collagen cross-linking, expressed as moles of cross-link per mole of collagen.
collagen Binding (cross) of
1) Confidence 0.43 Published 1996 Journal Am. J. Physiol. Section Abstract Doc Link 8853393 Disease Relevance 0 Pain Relevance 0.18
Thus, type VI collagen is abundant in the synovium of the mouse mandibular joint and is associated with proteoglycans or glycosaminoglycans, which might have a role in its formation.
collagen Spec (might) Binding (associated) of in joint
2) Confidence 0.41 Published 1995 Journal Arch. Oral Biol. Section Abstract Doc Link 8526809 Disease Relevance 0.07 Pain Relevance 0.07
pathway is involved in the synthesis of several extracellular macromolecules that interact with collagen.
collagen Binding (interact) of
3) Confidence 0.39 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2927597 Disease Relevance 0.15 Pain Relevance 0
Proteoglycans were associated with D-periodic collagen fibrils in the short filamentous form in random fashion at 1 week of age, but in a regular pattern with D-periodicity at 6 months.
collagen Binding (associated) of
4) Confidence 0.37 Published 2001 Journal Arch. Histol. Cytol. Section Abstract Doc Link 11310505 Disease Relevance 0.15 Pain Relevance 0.23
Degree of tissue remodeling and levels of collagen were determined by histological examination and a dye-binding collagen assay, respectively.
collagen Spec (examination) Binding (binding) of
5) Confidence 0.35 Published 2010 Journal J Anesth Section Body Doc Link 20127122 Disease Relevance 0.08 Pain Relevance 0
These results suggest that 1) elevated circulating IGF-1 may increase collagen deposition both in normal tissue as well as in granulation tissue by increasing collagen gene expression, 2) IGF-1 may increase collagen cross-linking by stimulating expression of lysyl oxidase, and 3) the preferential increase in dihydroxylated cross-links observed in high-growth mice may be due to the stimulation of lysyl hydroxylase expression by IGF-1.
collagen Binding (cross-linking) of in granulation
6) Confidence 0.33 Published 1996 Journal Am. J. Physiol. Section Abstract Doc Link 8853393 Disease Relevance 0 Pain Relevance 0.14
Collagen, expressed per weight of tissue, was significantly increased in all tissues from high-growth mice, as was collagen cross-linking, expressed as moles of cross-link per mole of collagen.
collagen Binding (linking) of
7) Confidence 0.32 Published 1996 Journal Am. J. Physiol. Section Abstract Doc Link 8853393 Disease Relevance 0 Pain Relevance 0.18
Immunohistochemical staining with anti-type VI collagen antibody was strongly positive in the intimal layer and moderately positive in the subsynovium.
collagen Binding (staining) of
8) Confidence 0.32 Published 1995 Journal Arch. Oral Biol. Section Abstract Doc Link 8526809 Disease Relevance 0.07 Pain Relevance 0.07
As the periodic dark bands were stained by ruthenium red, proteoglycan(s) or glycosaminoglycan(s) were probably associated with the type VI collagen fibrils.
collagen Binding (associated) of in bands
9) Confidence 0.32 Published 1995 Journal Arch. Oral Biol. Section Abstract Doc Link 8526809 Disease Relevance 0.07 Pain Relevance 0.07
In conclusion, cervical insufficiency does not appear to be associated with a constitutionally low cervical collagen concentration or collagen of inferior mechanical quality.
collagen Binding (associated) of in inferior
10) Confidence 0.29 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2927597 Disease Relevance 0.08 Pain Relevance 0
Other causes for the difference in collagen strength may reside in differences in the turnover rate of various processes of aging and cross-linking of collagen, or in different interactions between collagen and other extracellular matrix components.
collagen Binding (interactions) of in extracellular matrix associated with aging
11) Confidence 0.29 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2927597 Disease Relevance 0.16 Pain Relevance 0
It is, therefore, interesting that Warren et al. [12] found increased frequency of the TT genotype in the COL1A1 gene among CI-patients, a polymorphism associated with abnormal collagen triple-helix composition.
collagen Binding (associated) of
12) Confidence 0.29 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2927597 Disease Relevance 0.08 Pain Relevance 0
Cervical insufficiency does not appear to be associated with a constitutionally low collagen concentration or collagen of inferior mechanical quality.
collagen Binding (associated) of in inferior
13) Confidence 0.29 Published 2010 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC2927597 Disease Relevance 0 Pain Relevance 0
In conclusion, cervical insufficiency does not appear to be associated with a constitutionally low cervical collagen concentration or collagen of inferior mechanical quality.
collagen Binding (associated) of in inferior
14) Confidence 0.25 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2927597 Disease Relevance 0.08 Pain Relevance 0
Cervical insufficiency does not appear to be associated with a constitutionally low collagen concentration or collagen of inferior mechanical quality.
collagen Binding (associated) of in inferior
15) Confidence 0.25 Published 2010 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC2927597 Disease Relevance 0 Pain Relevance 0
These wounds were covered by sheets of cultured epidermal graft (group A), cultured epidermal graft with collagen dermis and fibrin (group B), cultured epidermal graft with collagen dermis (group C), or cultured epidermal graft with fibrin (group D).
collagen Binding (graft) of in dermis associated with injury
16) Confidence 0.22 Published 1999 Journal Ann Plast Surg Section Abstract Doc Link 10560869 Disease Relevance 0.32 Pain Relevance 0.10
Previous in vitro cell experiments revealed that cell adhesion and cell viability of murine fibroblasts is significantly enhanced on plasma-activated and collagen-coated silicone implants.26 Besides, it was observed that the surface modification by gas plasma influenced the progress of new vessel formation and promoted vascular infiltration in polymer scaffolds.21
collagen Binding (plasma) of in plasma associated with adhesions
17) Confidence 0.21 Published 2010 Journal Eplasty Section Body Doc Link PMC2948451 Disease Relevance 0.23 Pain Relevance 0
CONCLUSION: 89SrCl2 acts as a calcium mimic and, as such, becomes associated with the collagen matrix produced by the MC3T3-E1 cells during collagen mineralization.


collagen Binding (associated) of in MC3T3-E1
18) Confidence 0.19 Published 2000 Journal J. Nucl. Med. Section Body Doc Link 10647622 Disease Relevance 0 Pain Relevance 0
PSACH-MED patients have a well-characterized ligamentous laxity (2), and the ligaments from patients with COMP-T3 mutations can exhibit a disorganized collagen fibril network, with both variable fibril diameters and lateral fusion of neighbouring fibrils (unpublished data) (15).
collagen Binding (exhibit) of in lateral associated with osteochondrodysplasias
19) Confidence 0.17 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2792148 Disease Relevance 0.43 Pain Relevance 0
These collagen alterations may be a consequence of age-associated changes of collagen cross-linking [58], [59], [60] and impairment of its degradation [61] rendering an accumulation of partially degraded fibrils [44].
collagen Binding (linking) of
20) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2931699 Disease Relevance 0.94 Pain Relevance 0.16

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