INT61036

Context Info Confidence 0.50 First Reported 1996 Last Reported 2009 Negated 0 Speculated 0 Reported most in Abstract Documents 12 Total Number 12 Disease Relevance 7.45 Pain Relevance 4.46

extracellular space (Selp) nucleolus (Selp) nucleus (Selp) cytoplasm (Selp)

Anatomy Link Frequency plasma 2 coronary sinus 1 plaque 1 epithelial cell 1 Selp (Rattus norvegicus)

Pain Link Frequency Relevance Heat Angina 55 100.00 Percutaneous transluminal coronary angioplasty 7 99.56 ischemia 4 97.56 Pain 2 97.16 withdrawal 7 88.32 noradrenaline 3 87.08 Inflammatory marker 7 85.32 headache 1 82.80 cINOD 5 75.44 aspirin 14 74.72

Disease Link Frequency Relevance Heat Cv General 3 Under Development 40 100.00 Sleep Disorders 3 99.56 Myocardial Infarction 27 99.40 Stable Angina Pectoris 14 98.40 Cv Unclassified Under Development 2 97.56 Sickle Cell Anemia 3 96.12 Necrosis 2 95.88 Adhesions 11 95.48 Coronary Artery Disease 5 88.60 Dyslipidemia / Combined Dyslipidemia 1 86.80

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

This novel finding suggests that P-selectin inhibition be considered as a potential approach to therapy for the treatment of painful vaso-occlusion in sickle cell disease.

Negative_regulation (inhibition) of P-selectin associated with sickle cell anemia and pain

1) Confidence 0.50 Published 2001 Journal Blood Section Abstract Doc Link 11535535 Disease Relevance 0.43 Pain Relevance 0.15

In both AMI and UA, S-nitrosoglutathione reduced P-selectin (P < .001) and glycoprotein IIb/IIIa (P < .05) expression, as did glyceryl trinitrate (P < .02 and P < .01, respectively).

Negative_regulation (reduced) of P-selectin associated with angina and myocardial infarction

2) Confidence 0.40 Published 1996 Journal Arterioscler. Thromb. Vasc. Biol. Section Abstract Doc Link 8548426 Disease Relevance 1.57 Pain Relevance 0.88

The blocking ICAM-1 and P-selectin MAbs both inhibited Indo-induced increases in lesion score, mucosal permeability, and epithelial cell necrosis.

Negative_regulation (blocking) of P-selectin in epithelial cell associated with necrosis

3) Confidence 0.39 Published 1998 Journal Am. J. Physiol. Section Abstract Doc Link 9486176 Disease Relevance 0.58 Pain Relevance 0.39

Plasma P-selectin was decreased by direct PTCA in all of the 20 patients with AMI (from 176.2 +/- 17.7 ng/mL to 141.7 +/- 12.6 ng/mL; p<0.001, paired t-test), whereas it was increased by thrombolysis using TPA in nine of the 10 AMI patients (from 177.4 +/- 17.2 ng/mL to 248.8 +/- 17.3 ng/mL, p<0.005).

Negative_regulation (decreased) of P-selectin in Plasma associated with myocardial infarction and percutaneous transluminal coronary angioplasty

4) Confidence 0.36 Published 1998 Journal Angiology Section Abstract Doc Link 9783645 Disease Relevance 1.10 Pain Relevance 0.56

However, both PAG rate and P-selectin level decreased to a greater extent in the trial group than in the control group after treatment, and the difference between treatment was significant (both p<0.05).

Negative_regulation (decreased) of P-selectin

5) Confidence 0.29 Published 2007 Journal J Altern Complement Med Section Body Doc Link 17604562 Disease Relevance 0 Pain Relevance 0

However, both the PAG rate and P-selectin level decreased to a greater extent in the trial group than in the control group after treatment, and the difference between the two groups was significant (both p < 0.05).

Negative_regulation (decreased) of P-selectin

6) Confidence 0.29 Published 2007 Journal J Altern Complement Med Section Body Doc Link 17480139 Disease Relevance 0 Pain Relevance 0

[Decreased plasma soluble P-selectin level in coronary sinus after successful coronary angioplasty in patients with unstable angina].

Negative_regulation (Decreased) of P-selectin in coronary sinus associated with angina

7) Confidence 0.20 Published 1999 Journal J Cardiol Section Title Doc Link 10354952 Disease Relevance 0.43 Pain Relevance 0.33

Increased plasma soluble P-selectin (159.7 +/- 74.5 vs 78.7 +/- 26.4 ng/ml, p < 0.01) and PF-4 (456.5 +/- 87.0 vs 118.7 +/- 62.3 IU/ml, p < 0.01) levels were found in patients with unstable angina compared with those in controls, and were significantly decreased after angioplasty (147.8 +/- 69.6 ng/ml, p < 0.05; 401.6 +/- 108.5 IU/ml, p < 0.05), whereas von Willebrand factor antigen was unchanged.

Negative_regulation (decreased) of P-selectin in plasma associated with angina

8) Confidence 0.20 Published 1999 Journal J Cardiol Section Abstract Doc Link 10354952 Disease Relevance 0.53 Pain Relevance 0.47

Endothelial function improved progressively and C-reactive protein, P-selectin, and tissue plasminogen activator inhibitor levels decreased, but there was no decrease in exercise electrocardiographic ischemia.

Negative_regulation (decreased) of P-selectin associated with ischemia

9) Confidence 0.08 Published 2003 Journal Am. J. Cardiol. Section Abstract Doc Link 14609594 Disease Relevance 0.42 Pain Relevance 0.29

P-selectin levels, on the other hand, appeared to increase slightly two weeks after clopidogrel cessation (from 44 to 50 ng/ml; P < 0.001) and then decreased to the baseline levels (45 ng/ml; P = 0.488) after 4 weeks (Table 3B).

Negative_regulation (decreased) of P-selectin

10) Confidence 0.07 Published 2009 Journal J Thromb Thrombolysis Section Body Doc Link PMC2766044 Disease Relevance 0.64 Pain Relevance 0.28

In conclusion, determination of serum VCAM-1, E-selectin and P-selectin levels seems more useful for detecting coronary plaque destabilization.

Negative_regulation (determination) of P-selectin in plaque

11) Confidence 0.05 Published 2004 Journal Int. J. Cardiol. Section Abstract Doc Link 15262039 Disease Relevance 1.37 Pain Relevance 0.92

Sedation before interventions reduces sP-selectin levels, initial phase of coagulation and, consequently, myocardial damage.

Negative_regulation (reduces) of sP-selectin associated with sleep disorders

12) Confidence 0.04 Published 2006 Journal Int. J. Clin. Pract. Section Abstract Doc Link 16700848 Disease Relevance 0.30 Pain Relevance 0.18

General Comments

This test has worked.