INT61065

Context Info Confidence 0.69 First Reported 1996 Last Reported 2009 Negated 0 Speculated 1 Reported most in Body Documents 9 Total Number 10 Disease Relevance 1.13 Pain Relevance 0.30

signal transduction (Igfbp2) extracellular space (Igfbp2) aging (Igfbp2) extracellular region (Igfbp2) response to stress (Igfbp2)

Anatomy Link Frequency osteocytes 5 shaft 1 Igfbp2 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Clonidine 2 98.32 cytokine 1 84.08 anesthesia 13 64.08 nMDA receptor 9 50.00 alcohol 14 5.00 medulla 14 5.00 isoflurane 13 5.00 Hippocampus 7 5.00 Glutamate receptor 4 5.00 potassium channel 3 5.00

Disease Link Frequency Relevance Heat Apoptosis 6 92.12 Stress 12 91.32 Hypoxia 144 90.08 Hypophysis Disease 1 85.48 Gangliosidoses 2 75.00 Osteoporosis 7 70.32 Death 2 66.72 Sprains And Strains 14 48.24 Hypercalcemia 7 7.08 Hypersensitivity 30 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In conclusion, 6 hours after a single loading session, the number of IGFBP-2 mRNA-expressing osteocytes at the endosteal side of the shaft and inner lamellae was increased in squeezed and bended tibiae.

Positive_regulation (increased) of IGFBP-2 mRNA in shaft

1) Confidence 0.69 Published 2007 Journal Calcif Tissue Int Section Abstract Doc Link PMC1914289 Disease Relevance 0 Pain Relevance 0

An increase of IGFBP-2 mRNA-positive osteocytes was shown in loaded (1.68-fold) and sham-loaded (1.35-fold) endocortical tibial shaft.

Positive_regulation (increase) of IGFBP-2 mRNA in osteocytes

2) Confidence 0.69 Published 2007 Journal Calcif Tissue Int Section Abstract Doc Link PMC1914289 Disease Relevance 0 Pain Relevance 0

We conclude that bending and squeezing of rat tibiae result in an increase of locally synthesized IGFBP-2 mRNA by endocortical osteocytes.

Positive_regulation (increase) of IGFBP-2 mRNA in osteocytes

3) Confidence 0.69 Published 2007 Journal Calcif Tissue Int Section Body Doc Link PMC1914289 Disease Relevance 0 Pain Relevance 0

Apparently, besides bending, squeezing alone is also responsible for the upregulation of IGFBP-2 mRNA in the endocortical osteocytes.

Positive_regulation (upregulation) of IGFBP-2 mRNA in osteocytes

4) Confidence 0.69 Published 2007 Journal Calcif Tissue Int Section Body Doc Link PMC1914289 Disease Relevance 0 Pain Relevance 0

Mechanical loading significantly increased the number of IGFBP-2 mRNA-synthesizing osteocytes in loaded tibiae (P = 0.001) and in sham-loaded tibiae (P = 0.031) (Fig. 2A, B).

Positive_regulation (increased) of IGFBP-2 mRNA in osteocytes

5) Confidence 0.69 Published 2007 Journal Calcif Tissue Int Section Body Doc Link PMC1914289 Disease Relevance 0 Pain Relevance 0

We hypothesized that IGFBP-2 mRNA expression level might be changed in bone cells during bone formation after mechanical stimulation.

Positive_regulation (changed) of IGFBP-2 mRNA

6) Confidence 0.50 Published 2007 Journal Calcif Tissue Int Section Body Doc Link PMC1914289 Disease Relevance 0.07 Pain Relevance 0

This in vivo study showed an increase in the number of endocortical osteocytes expressing IGFBP-2 mRNA in loaded (1.68-fold) and sham-loaded (1.35-fold) tibiae 6 hours after a single period of mechanical loading with the four-point bending system.

Positive_regulation (increase) of IGFBP-2 mRNA in osteocytes

7) Confidence 0.47 Published 2007 Journal Calcif Tissue Int Section Body Doc Link PMC1914289 Disease Relevance 0 Pain Relevance 0

were identified, and included inducible nitric oxide synthetase 2, insulin-like growth factor 1, insulin-like growth factor binding protein 2, and hexokinase 2.

Positive_regulation (inducible) of insulin-like growth factor binding protein 2

8) Confidence 0.14 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2635851 Disease Relevance 0.63 Pain Relevance 0.04

Patients were compared to normal men by investigating GH sampling every 10 min for 24 h and serum levels of insulin-like growth factor I (IGF-I), IGF-binding protein 2 (IGFBP-2), IGFBP-3, and GH-binding protein.

Spec (investigating) Positive_regulation (investigating) of IGF-binding protein 2

9) Confidence 0.09 Published 1996 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 8550799 Disease Relevance 0.09 Pain Relevance 0.19

Additionally, IGF-binding protein-3 was reduced, and IGF-binding protein-2 was elevated significantly in GM1 mutant cats more than 200 days of age.

Positive_regulation (elevated) of IGF-binding protein-2

10) Confidence 0.05 Published 1999 Journal Endocrinology Section Abstract Doc Link 10579334 Disease Relevance 0.35 Pain Relevance 0.06

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