INT61067

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Context Info
Confidence 0.41
First Reported 1996
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.21
Pain Relevance 0.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Igfbp3) nucleus (Igfbp3)
Anatomy Link Frequency
Plasma 1
Igfbp3 (Mus musculus)
Pain Link Frequency Relevance Heat
Clonidine 2 98.32 Very High Very High Very High
chemokine 7 90.40 High High
cytokine 6 89.92 High High
metalloproteinase 4 75.00 Quite High
ketamine 1 68.40 Quite High
anesthesia 2 67.16 Quite High
Inflammation 4 5.00 Very Low Very Low Very Low
palliative 2 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 64 99.56 Very High Very High Very High
Hypophysis Disease 1 85.48 High High
Stomach Cancer 58 62.56 Quite High
Targeted Disruption 1 59.36 Quite High
Malignant Neoplastic Disease 10 45.76 Quite Low
Metastasis 7 5.00 Very Low Very Low Very Low
Gastritis 7 5.00 Very Low Very Low Very Low
Disease 7 5.00 Very Low Very Low Very Low
INFLAMMATION 5 5.00 Very Low Very Low Very Low
Adenocarcinoma 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Plasma levels of MMP-9, a known protease of IGFBP-3, are significantly elevated postoperatively.
Positive_regulation (elevated) of IGFBP-3 in Plasma
1) Confidence 0.41 Published 2005 Journal Surgical innovation Section Abstract Doc Link 16424954 Disease Relevance 0.06 Pain Relevance 0.17
36 h) increase in IGF-1 and IGFBP-3 that leveled out to correlate to average hGH levels.
Positive_regulation (increase) of IGFBP-3
2) Confidence 0.23 Published 2007 Journal Pharm Res Section Body Doc Link PMC2063566 Disease Relevance 0 Pain Relevance 0
, IGFBP3, SPP1/OPN and TIMP1 were increased in PN and tumours relative to AN, with higher levels seen in tumours.
Positive_regulation (increased) of IGFBP3 associated with cancer
3) Confidence 0.05 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC3004887 Disease Relevance 1.07 Pain Relevance 0.14
Patients were compared to normal men by investigating GH sampling every 10 min for 24 h and serum levels of insulin-like growth factor I (IGF-I), IGF-binding protein 2 (IGFBP-2), IGFBP-3, and GH-binding protein.
Spec (investigating) Positive_regulation (investigating) of IGFBP-3
4) Confidence 0.03 Published 1996 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 8550799 Disease Relevance 0.09 Pain Relevance 0.19

General Comments

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