INT61084

From wiki-pain
Revision as of 08:55, 21 September 2012 by Daniel (Talk | contribs)

(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to: navigation, search
Context Info
Confidence 0.10
First Reported 1995
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 5
Total Number 7
Disease Relevance 2.68
Pain Relevance 2.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
spinal cord 2
ileum 1
Gut 1
Dcp1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 8 99.36 Very High Very High Very High
diabetic neuropathy 4 98.92 Very High Very High Very High
c fibre 2 98.40 Very High Very High Very High
dorsal root ganglion 10 98.36 Very High Very High Very High
Abeta 2 97.28 Very High Very High Very High
sodium channel 4 95.16 Very High Very High Very High
Nucleus accumbens 10 94.28 High High
Adelta 2 94.08 High High
Inflammation 120 92.48 High High
dopamine receptor 4 87.60 High High
Disease Link Frequency Relevance Heat
Injury 153 99.44 Very High Very High Very High
Diabetic Neuropathy 4 98.92 Very High Very High Very High
Ganglion Cysts 10 98.08 Very High Very High Very High
INFLAMMATION 126 92.48 High High
Neuropathic Pain 4 80.24 Quite High
Burns 9 5.00 Very Low Very Low Very Low
Congenital Anomalies 9 5.00 Very Low Very Low Very Low
Sepsis 9 5.00 Very Low Very Low Very Low
Sleep Disorders 3 5.00 Very Low Very Low Very Low
Adhesions 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Following streptozocin treatment, the expression of beta1 mRNA remained unchanged in both the spinal cord and DRG whilst beta3 message was significantly increased in both the spinal cord and in medium diameter Adelta type DRG neurones.
Gene_expression (expression) of beta1 mRNA in spinal cord associated with dorsal root ganglion, adelta and spinal cord
1) Confidence 0.10 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11489532 Disease Relevance 0.72 Pain Relevance 0.93
Under control conditions beta1 mRNA was detected throughout the spinal cord and in large dorsal root ganglion (DRG) Abeta fibres whilst beta3 mRNA was expressed exclusively in the layers I/II and X of the spinal cord and in small DRG c-fibres.
Gene_expression (detected) of beta1 mRNA in spinal cord associated with ganglion cysts, c fibre, dorsal root ganglion, abeta and spinal cord
2) Confidence 0.08 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11489532 Disease Relevance 0.66 Pain Relevance 0.79
All detectable prodynorphin cells in the core expressed D1 mRNA but not D2 mRNA.
Neg (not) Gene_expression (expressed) of D1 mRNA
3) Confidence 0.07 Published 1995 Journal J. Comp. Neurol. Section Abstract Doc Link 8550882 Disease Relevance 0 Pain Relevance 0.29
Conversely, approximately 95% of the proenkephalin-positive cells in this region expressed D2 mRNA but not D1 mRNA.
Neg (not) Gene_expression (expressed) of D1 mRNA
4) Confidence 0.07 Published 1995 Journal J. Comp. Neurol. Section Abstract Doc Link 8550882 Disease Relevance 0 Pain Relevance 0.28
To further assess whether melatonin exerts feedback on its own production, we compared the effects of boosting melatonin levels by administering exogenous melatonin by i.p. injection of 1ml/250g b.wt. doses at 2 or 8 mM concentrations two hours before measuring the ileum expression levels of the melatonin synthesizing enzyme mRNA.
Gene_expression (expression) of melatonin synthesizing enzyme mRNA in ileum
5) Confidence 0.02 Published 2010 Journal International Journal of Biological Sciences Section Body Doc Link PMC2878173 Disease Relevance 0.26 Pain Relevance 0.04
Gut melatonin is dynamically adjusted as both mesenteric and systemic melatonin levels are increased three days following major thermal injury (Fig. 1A), AA-NAT and HIOMT mRNA expression is increased three days following major thermal injury (Fig. 1B and 1C), and exogenous melatonin suppresses melatonin synthesizing enzyme mRNA expression (Fig. 1C).
Gene_expression (expression) of melatonin synthesizing enzyme mRNA in Gut associated with injury
6) Confidence 0.02 Published 2010 Journal International Journal of Biological Sciences Section Body Doc Link PMC2878173 Disease Relevance 0.70 Pain Relevance 0.07
Remarkably, melatonin synthesizing enzyme mRNA expression appears to undergo suppression in sham rats following exogenous intraperitoneal melatonin injection possibly starting at concentrations as low as those seen postburn (2 mM; Fig. 1).
Gene_expression (expression) of melatonin synthesizing enzyme mRNA
7) Confidence 0.02 Published 2010 Journal International Journal of Biological Sciences Section Body Doc Link PMC2878173 Disease Relevance 0.34 Pain Relevance 0.07

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox