INT61102

From wiki-pain
Revision as of 04:41, 21 September 2012 by Daniel (Talk | contribs)

(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to: navigation, search
Context Info
Confidence 0.78
First Reported 1996
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 13
Disease Relevance 17.70
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MEN1) nucleolus (MEN1) nucleus (MEN1)
protein binding, bridging (MEN1) embryo development (MEN1) DNA binding (MEN1)
Anatomy Link Frequency
tail region 1
parathyroid 1
MEN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
peptic ulcer disease 1 97.98 Very High Very High Very High
Somatostatin 32 96.08 Very High Very High Very High
imagery 70 88.80 High High
Central nervous system 10 72.96 Quite High
depression 10 67.52 Quite High
corticosteroid 10 5.00 Very Low Very Low Very Low
abdominal pain 10 5.00 Very Low Very Low Very Low
agonist 10 5.00 Very Low Very Low Very Low
Dopamine 10 5.00 Very Low Very Low Very Low
headache 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Multiple Endocrine Neoplasia Type 1 1046 100.00 Very High Very High Very High
Syndrome 259 100.00 Very High Very High Very High
Hypercalcemia 153 100.00 Very High Very High Very High
Cancer 674 99.76 Very High Very High Very High
Neuroendocrine Cancer 14 99.56 Very High Very High Very High
Pancreatic Cancer 125 99.48 Very High Very High Very High
Disease 81 97.98 Very High Very High Very High
Ulcers 11 97.82 Very High Very High Very High
Hyperplasia 21 96.80 Very High Very High Very High
Insulinoma 64 96.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pancreatic tumours occur in about 30–80% of MEN1 patients and are the second most frequently expressed clinical manifestation of MEN1.
Gene_expression (expressed) of MEN1 associated with multiple endocrine neoplasia type 1 and pancreatic cancer
1) Confidence 0.78 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1594566 Disease Relevance 2.19 Pain Relevance 0.04
Recent studies have demonstrated that over-expression of menin in a Ras-transformed NIH3T3 cell model reversed the transformed phenotype [51], inducing decreased proliferation, suppression of growth in soft agar and inhibition of tumour growth in nude mice.
Gene_expression (over) of menin associated with cancer
2) Confidence 0.78 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1594566 Disease Relevance 0.28 Pain Relevance 0
Mutational analysis of the MEN1 gene is recommended for patients who meet the clinical criteria for MEN1 and for those in whom a diagnosis of MEN1 is suspected.
Gene_expression (diagnosis) of MEN1 associated with multiple endocrine neoplasia type 1
3) Confidence 0.67 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1594566 Disease Relevance 1.14 Pain Relevance 0
Individuals who have a 50% risk of having MEN1 syndrome, but whose genetic status is unknown, should undergo the following tests:
Gene_expression (syndrome) of MEN1 associated with multiple endocrine neoplasia type 1 and syndrome
4) Confidence 0.67 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1594566 Disease Relevance 0.97 Pain Relevance 0.18
Mutational analysis of the MEN1 gene is recommended for patients who meet the clinical criteria for MEN1 and for those in whom a diagnosis of MEN1 is suspected.
Gene_expression (diagnosis) of MEN1 associated with multiple endocrine neoplasia type 1
5) Confidence 0.67 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1594566 Disease Relevance 1.39 Pain Relevance 0
The MEN1 protein (menin)
Gene_expression (The) of MEN1 protein associated with multiple endocrine neoplasia type 1
6) Confidence 0.67 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1594566 Disease Relevance 0.79 Pain Relevance 0
Pancreatic tumours occur in about 30–80% of MEN1 patients and are the second most frequently expressed clinical manifestation of MEN1.
Gene_expression (expressed) of MEN1 associated with multiple endocrine neoplasia type 1 and pancreatic cancer
7) Confidence 0.67 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1594566 Disease Relevance 2.16 Pain Relevance 0.04
PHPT in MEN1 manifests with hypercalcaemia as a result of overproduction of parathyroid hormone (PTH) by tumoural and supernumerary parathyroid glands.
Gene_expression (overproduction) of MEN1 in parathyroid associated with multiple endocrine neoplasia type 1 and hypercalcemia
8) Confidence 0.67 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1594566 Disease Relevance 3.16 Pain Relevance 0.07
The MEN1 protein (menin)
Gene_expression (The) of menin associated with multiple endocrine neoplasia type 1
9) Confidence 0.67 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1594566 Disease Relevance 0.79 Pain Relevance 0
Recent studies have demonstrated that over-expression of menin in a Ras-transformed NIH3T3 cell model reversed the transformed phenotype [51], inducing decreased proliferation, suppression of growth in soft agar and inhibition of tumour growth in nude mice.
Gene_expression (expression) of menin associated with cancer
10) Confidence 0.60 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1594566 Disease Relevance 0.28 Pain Relevance 0
The differentially expressed genes in the MEN1 syndrome were not similar to those identified in this study, and suggest a different pathogenesis for spontaneous islet cell tumors.
Gene_expression (expressed) of MEN1 associated with multiple endocrine neoplasia type 1, islet cell adenoma and syndrome
11) Confidence 0.57 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1824711 Disease Relevance 1.59 Pain Relevance 0
The gene expression profile for neuroendocrine tumors in patients with the MEN1 syndrome was recently reported [44].
Gene_expression (syndrome) of MEN1 associated with multiple endocrine neoplasia type 1, neuroendocrine cancer and syndrome
12) Confidence 0.49 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1824711 Disease Relevance 1.42 Pain Relevance 0
A brother was found to suffer from peptic ulcer disease caused by hyperparathyroidism and, during screening for other organ involvement associated with the MEN I syndrome, two tumors were found, one (4 cm) in the pancreatic tail region and one in the right adrenal gland.
Gene_expression (syndrome) of MEN I in tail region associated with multiple endocrine neoplasia type 1, cancer, syndrome, peptic ulcer disease, hypercalcemia and disease
13) Confidence 0.12 Published 1996 Journal Jpn. J. Clin. Oncol. Section Abstract Doc Link 8551667 Disease Relevance 1.55 Pain Relevance 0.10

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox