INT61116

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Context Info
Confidence 0.69
First Reported 1995
Last Reported 2010
Negated 3
Speculated 1
Reported most in Body
Documents 119
Total Number 120
Disease Relevance 58.62
Pain Relevance 21.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Ppara) nucleus (Ppara) DNA binding (Ppara)
Anatomy Link Frequency
liver 3
HF1 2
spinal cord 2
granulosa cells 2
plasma 1
Ppara (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 1140 100.00 Very High Very High Very High
Inflammation 689 100.00 Very High Very High Very High
Cannabinoid 6 100.00 Very High Very High Very High
Potency 159 99.92 Very High Very High Very High
Spinal cord 16 99.68 Very High Very High Very High
Hyperalgesia 9 99.68 Very High Very High Very High
cocaine 5 99.56 Very High Very High Very High
Nicotine 18 99.32 Very High Very High Very High
Inflammatory mediators 8 99.16 Very High Very High Very High
cINOD 228 99.08 Very High Very High Very High
Disease Link Frequency Relevance Heat
Metabolic Syndrome 184 99.92 Very High Very High Very High
Coronary Heart Disease 85 99.92 Very High Very High Very High
Hyperalgesia 9 99.68 Very High Very High Very High
Apoptosis 1013 99.62 Very High Very High Very High
INFLAMMATION 823 99.60 Very High Very High Very High
Hypersensitivity 53 99.60 Very High Very High Very High
Obesity 795 99.52 Very High Very High Very High
Fatty Liver 29 99.46 Very High Very High Very High
Arthritis 785 99.30 Very High Very High Very High
Cancer 271 98.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In view of the consequences of PPARalpha activation in other tissues, these results suggest that fatty acid utilization is enhanced in the CNS during chronic pain state.
Positive_regulation (activation) of PPARalpha in CNS associated with lasting pain and central nervous system
1) Confidence 0.69 Published 2004 Journal Neurosci. Lett. Section Abstract Doc Link 15380308 Disease Relevance 0.29 Pain Relevance 0.61
Using electrophoretic mobility-shift assay (EMSA), we found that only the PPARalpha isoform was activated in the rat spinal cord after CFA injection.
Positive_regulation (activated) of PPARalpha in spinal cord associated with spinal cord
2) Confidence 0.69 Published 2004 Journal Neurosci. Lett. Section Abstract Doc Link 15380308 Disease Relevance 0.30 Pain Relevance 0.58
Some compounds such as carbaprostacyclin bind and activate PPAR?
Positive_regulation (activate) of PPAR
3) Confidence 0.65 Published 2010 Journal PPAR Research Section Body Doc Link PMC2938460 Disease Relevance 1.13 Pain Relevance 0.19
It was reported that thiazolidinediones at concentrations that activate the PPAR?
Positive_regulation (activate) of PPAR
4) Confidence 0.65 Published 2010 Journal PPAR Research Section Body Doc Link PMC2938460 Disease Relevance 1.06 Pain Relevance 0.37
Activation of peroxisome proliferator-activated receptor-alpha (PPAR-?)
Positive_regulation (Activation) of peroxisome proliferator-activated receptor-alpha
5) Confidence 0.61 Published 2010 Journal Experimental Diabetes Research Section Abstract Doc Link PMC3014714 Disease Relevance 0.86 Pain Relevance 0.14
It

is possible, however, that ICI may have directly repressed activation of PPAR?

Positive_regulation (activation) of PPAR
6) Confidence 0.61 Published 2008 Journal PPAR Research Section Body Doc Link PMC2519140 Disease Relevance 0.40 Pain Relevance 0.05
metabolites of the latter can directly activate PPAR?
Positive_regulation (activate) of PPAR
7) Confidence 0.61 Published 2008 Journal PPAR Research Section Body Doc Link PMC2519140 Disease Relevance 0.20 Pain Relevance 0
activation of PPAR?
Positive_regulation (activation) of PPAR
8) Confidence 0.61 Published 2008 Journal PPAR Research Section Body Doc Link PMC2519140 Disease Relevance 0.69 Pain Relevance 0.18
The latter effect, however, was not associated with induced PPAR?
Neg (not) Positive_regulation (induced) of PPAR
9) Confidence 0.61 Published 2008 Journal PPAR Research Section Body Doc Link PMC2519140 Disease Relevance 0.15 Pain Relevance 0
The upregulation of PPAR?
Positive_regulation (upregulation) of PPAR
10) Confidence 0.61 Published 2008 Journal PPAR Research Section Body Doc Link PMC2519140 Disease Relevance 0 Pain Relevance 0
Activation of peroxisome proliferator-activated receptor alpha in rat spinal cord after peripheral noxious stimulation.
Positive_regulation (Activation) of proliferator-activated receptor alpha in spinal cord associated with inflammation and spinal cord
11) Confidence 0.60 Published 2004 Journal Neurosci. Lett. Section Title Doc Link 15380308 Disease Relevance 0.24 Pain Relevance 0.51
agonists was not due to the direct cardiac effects of PPAR agonists, for example, activation of cardiac PPAR-?
Neg (not) Positive_regulation (activation) of PPAR associated with agonist
12) Confidence 0.60 Published 2009 Journal PPAR Research Section Body Doc Link PMC2696219 Disease Relevance 0.85 Pain Relevance 0.10
, whereas increased PPAR?
Positive_regulation (increased) of PPAR
13) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2900215 Disease Relevance 1.07 Pain Relevance 0.03
activation of penile PPAR?
Positive_regulation (activation) of PPAR
14) Confidence 0.53 Published 2008 Journal PPAR Research Section Body Doc Link PMC2519140 Disease Relevance 0.75 Pain Relevance 0.17
The activation of PPAR potentially affects a large number of physiological processes, including adipocyte differentiation, with actual activity determined in combination with various co-activators.
Positive_regulation (activation) of PPAR in adipocyte
15) Confidence 0.51 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794370 Disease Relevance 0.49 Pain Relevance 0.12
The anti-apoptotic actions of ligand-activated PPAR?
Positive_regulation (activated) of PPAR associated with apoptosis
16) Confidence 0.47 Published 2010 Journal PPAR Research Section Body Doc Link PMC2938460 Disease Relevance 1.13 Pain Relevance 0.10
Furthermore, ligand-activated PPAR?
Positive_regulation (activated) of PPAR
17) Confidence 0.47 Published 2010 Journal PPAR Research Section Body Doc Link PMC2938460 Disease Relevance 0.94 Pain Relevance 0.04
Ligand-activated PPAR?
Positive_regulation (activated) of PPAR
18) Confidence 0.47 Published 2010 Journal PPAR Research Section Body Doc Link PMC2938460 Disease Relevance 0.66 Pain Relevance 0.09
Thus, ligand-activated PPAR?
Positive_regulation (activated) of PPAR
19) Confidence 0.47 Published 2010 Journal PPAR Research Section Body Doc Link PMC2938460 Disease Relevance 0.48 Pain Relevance 0
Thus, ligand-activated PPAR?
Positive_regulation (activated) of PPAR
20) Confidence 0.47 Published 2010 Journal PPAR Research Section Body Doc Link PMC2938460 Disease Relevance 0.74 Pain Relevance 0.10

General Comments

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