INT61223

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Context Info
Confidence 0.49
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 5.92
Pain Relevance 1.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (ACE) peptidase activity (ACE) extracellular space (ACE)
extracellular region (ACE) plasma membrane (ACE)
Anatomy Link Frequency
plasma 2
arms 2
heart 2
ACE (Homo sapiens)
Pain Link Frequency Relevance Heat
bradykinin 18 100.00 Very High Very High Very High
beta blocker 19 99.68 Very High Very High Very High
antagonist 16 98.92 Very High Very High Very High
substance P 4 98.44 Very High Very High Very High
alcohol 4 94.48 High High
qutenza 7 93.96 High High
depression 26 92.52 High High
agonist 1 87.28 High High
Pain 10 85.20 High High
abdominal pain 5 73.00 Quite High
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 88 99.98 Very High Very High Very High
Cough 13 99.84 Very High Very High Very High
Heart Rate Under Development 15 99.12 Very High Very High Very High
Hypertension 90 98.60 Very High Very High Very High
Diabetes Mellitus 27 98.32 Very High Very High Very High
Disease 61 98.04 Very High Very High Very High
Myocardial Infarction 63 97.72 Very High Very High Very High
Hereditary Angioedema 133 97.28 Very High Very High Very High
Acute Coronary Syndrome 28 97.28 Very High Very High Very High
Depression 28 92.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Accumulation of bradykinin via inhibition of ACE may increase NO synthesis or activity, resulting in improved vasodilative response.
Positive_regulation (Accumulation) of Negative_regulation (inhibition) of ACE associated with bradykinin
1) Confidence 0.49 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663435 Disease Relevance 0.30 Pain Relevance 0.19
The present study suggests that SP is a common mechanism mediating increases in the sensitivity of cough reflex induced by both ACE inhibition and a decrease in plasma estrogen levels, and the additive effects of the two events may explain the high incidence of cough during ACE inhibitor therapy in perimenopausal and postmenopausal women.
Positive_regulation (induced) of Negative_regulation (inhibition) of ACE in plasma associated with cough and substance p
2) Confidence 0.49 Published 1996 Journal Am. J. Respir. Crit. Care Med. Section Abstract Doc Link 8564137 Disease Relevance 0.56 Pain Relevance 0.61
Patients in ASCOT-BPLA were randomized to initial treatment with either a CCB or beta blocker which was then augmented with an ACE inhibitor or a thiazide diuretic in the respective arms.
Positive_regulation (augmented) of Negative_regulation (inhibitor) of ACE in arms associated with beta blocker
3) Confidence 0.48 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012553 Disease Relevance 0.49 Pain Relevance 0.19
(b) angioedema due to angiotensin converting enzyme inhibitors and angiotensin-II receptor blockers
Positive_regulation (due) of Negative_regulation (inhibitors) of angiotensin converting enzyme associated with pressure and volume under development
4) Confidence 0.35 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2919521 Disease Relevance 2.93 Pain Relevance 0.16
Finally, one should also consider other major determinants of ACS outcomes, namely concomitant diseases like diabetes, hypertension, congestive heart failure, etc., and the use of secondary preventive drugs like angiotensin converting enzyme inhibitors, ?
Positive_regulation (drugs) of Negative_regulation (inhibitors) of angiotensin converting enzyme in heart associated with heart rate under development, acute coronary syndrome, diabetes mellitus, hypertension and disease
5) Confidence 0.17 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1181243 Disease Relevance 0.77 Pain Relevance 0
Most patients were treated with ACE inhibitors or angiotensin-2 receptor antagonists, ?
Positive_regulation (treated) of Negative_regulation (inhibitors) of ACE associated with antagonist
6) Confidence 0.03 Published 2010 Journal Health Qual Life Outcomes Section Body Doc Link PMC2945966 Disease Relevance 0.87 Pain Relevance 0.23

General Comments

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