INT61311

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Context Info
Confidence 0.59
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 0.48
Pain Relevance 2.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Syn1) ligase activity (Syn1)
Anatomy Link Frequency
brain 4
neuroblast 2
Syn1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 19 99.62 Very High Very High Very High
monoamine 2 99.60 Very High Very High Very High
Hippocampus 1 96.96 Very High Very High Very High
cerebral cortex 1 96.44 Very High Very High Very High
Serotonin 2 92.80 High High
Dopamine 1 88.12 High High
substance P 8 85.00 Quite High
Enkephalin 8 84.72 Quite High
medulla 1 80.20 Quite High
noradrenaline 1 78.52 Quite High
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 8 76.04 Quite High
Fasciculation 2 64.08 Quite High
Metastasis 2 55.20 Quite High
Injury 2 54.64 Quite High
Cancer 4 54.56 Quite High
Death 2 52.56 Quite High
Apoptosis 12 5.00 Very Low Very Low Very Low
Neuroblastoma 6 5.00 Very Low Very Low Very Low
Infection 6 5.00 Very Low Very Low Very Low
Targeted Disruption 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In perinatal morphine-treated rats, the expression of synapsin I mRNA was significantly reduced; interestingly, the neonatal treatment with 6-hydroxydopamine normalized its expression.
Negative_regulation (reduced) of Gene_expression (expression) of synapsin I mRNA associated with morphine
1) Confidence 0.59 Published 1996 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8804907 Disease Relevance 0 Pain Relevance 0.90
Therefore, perinatal exposure to morphine affects early postnatal synaptic development in the brain as shown by the altered peptidergic and monoaminergic content and by the reduced synapsin I mRNA expression.
Negative_regulation (reduced) of Gene_expression (expression) of synapsin I mRNA in brain associated with monoamine and morphine
2) Confidence 0.55 Published 1995 Journal J. Neurosci. Res. Section Abstract Doc Link 8568934 Disease Relevance 0 Pain Relevance 0.93
In the brain of rats perinatally exposed to morphine, the abundance of synapsin I mRNA expression is markedly reduced.
Negative_regulation (reduced) of Gene_expression (expression) of synapsin I mRNA in brain associated with morphine
3) Confidence 0.55 Published 1995 Journal J. Neurosci. Res. Section Abstract Doc Link 8568934 Disease Relevance 0 Pain Relevance 1.01
This discrepancy may be due to the different levels of Syn-1 signaling, resulting from decreased or elevated expression of Syn-1, or reflect differences between mature hippocampal cells and neuroblast PC12 cells.
Negative_regulation (decreased) of Gene_expression (expression) of Syn-1 in neuroblast
4) Confidence 0.13 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2844376 Disease Relevance 0.43 Pain Relevance 0
Effect of an Akt-specific inhibitor on expression of MafK, SytI, and Syn-1 genes in PC12 (WT-Akt) cells
Negative_regulation (inhibitor) of Gene_expression (expression) of Syn-1
5) Confidence 0.10 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2844376 Disease Relevance 0.05 Pain Relevance 0

General Comments

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