INT61513

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Context Info
Confidence 0.64
First Reported 1995
Last Reported 2010
Negated 2
Speculated 1
Reported most in Abstract
Documents 71
Total Number 72
Disease Relevance 37.91
Pain Relevance 17.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Gpx1) mitochondrion (Gpx1) oxidoreductase activity (Gpx1)
nucleus (Gpx1) lipid metabolic process (Gpx1) cytoplasm (Gpx1)
Anatomy Link Frequency
liver 11
plasma 4
paw 3
epithelial cells 2
blood 2
Gpx1 (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 5 100.00 Very High Very High Very High
Paracetamol 74 99.98 Very High Very High Very High
fluoxetine 22 99.58 Very High Very High Very High
medulla 17 99.24 Very High Very High Very High
Visceral pain 14 99.20 Very High Very High Very High
diclofenac 18 99.02 Very High Very High Very High
Inflammation 388 98.16 Very High Very High Very High
ischemia 51 98.02 Very High Very High Very High
Prostatitis 99 96.76 Very High Very High Very High
Spinal cord 4 94.80 High High
Disease Link Frequency Relevance Heat
Stress 734 100.00 Very High Very High Very High
Hyperinsulinism 8 100.00 Very High Very High Very High
Diabetes Mellitus 804 99.84 Very High Very High Very High
Pressure And Volume Under Development 43 99.82 Very High Very High Very High
Myoma 42 99.78 Very High Very High Very High
Polyps 48 99.60 Very High Very High Very High
Hyperplasia 64 99.28 Very High Very High Very High
Cognitive Disorder 44 99.28 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

14 99.20 Very High Very High Very High
Toxicity 94 99.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The anti-inflammatory mechanism of FL and FM might be related to the decrease in the level of MDA in the edema paw via increasing the activities of GPx and GRx in the liver and decreasing the NO level in the edema paw.
Positive_regulation (increasing) of GPx in paw associated with pressure and volume under development and inflammation
1) Confidence 0.64 Published 2010 Journal Am. J. Chin. Med. Section Abstract Doc Link 20503477 Disease Relevance 0.91 Pain Relevance 0.42
Furthermore, TC(MeOH) and betulin treatment also significantly increased the activities of SOD, GR and GPx in the liver while decreasing the level of MDA in the edema paw.
Positive_regulation (increased) of GPx in paw associated with pressure and volume under development
2) Confidence 0.51 Published 2009 Journal Am. J. Chin. Med. Section Abstract Doc Link 19222115 Disease Relevance 0.73 Pain Relevance 0.37
The anti-inflammatory mechanism of WET might be related to the decrease in the level of MDA in the edema paw via increasing the activities of SOD, GPx and GRx in the liver.


Positive_regulation (increasing) of GPx in liver
3) Confidence 0.50 Published 2009 Journal J Ethnopharmacol Section Body Doc Link 19703536 Disease Relevance 0 Pain Relevance 0
The APAP treatment activated liver c-jun N-terminal kinase (JNK) in the WT and GPX1(-/-) mice, but not in the SOD1(-/-) mice.
Neg (not) Positive_regulation (activated) of GPX1 in liver associated with paracetamol
4) Confidence 0.49 Published 2006 Journal Exp. Biol. Med. (Maywood) Section Abstract Doc Link 17138759 Disease Relevance 0.51 Pain Relevance 0.68
FL and FM significantly increased the GRx and GPx activities in the liver and decreased the levels of malondialdehyde (MDA) and nitric oxide (NO) in the edema paw (p < 0.001).
Positive_regulation (increased) of GPx in liver associated with pressure and volume under development
5) Confidence 0.46 Published 2010 Journal Am. J. Chin. Med. Section Abstract Doc Link 20503477 Disease Relevance 0.89 Pain Relevance 0.46
The anti-inflammatory mechanisms of ST1 might be related to the decrease in the level of MDA, iNOS, and COX-2 in the edema paw via increasing the activities of CAT, SOD, and GPx in the liver through the suppression of TNF-alpha and NO.
Positive_regulation (increasing) of GPx in liver associated with pressure and volume under development and inflammation
6) Confidence 0.45 Published 2010 Journal J. Agric. Food Chem. Section Abstract Doc Link 20507140 Disease Relevance 0.93 Pain Relevance 0.29
In the present study a statistically significant increase in the levels of GSH, SOD, catalase and GPx in the diabetic treated mice with AuNPs in comparison to diabetic control is being proved which is due to the significant decrease in lipid peroxidation and ROS generation that was accomplished in diabetic treated mice with AuNPs, relative to diabetic control suggesting that AuNPs prevents disruption of organs by protecting lipids from peroxidation by ROS under hyperglycemic conditions.
Positive_regulation (increase) of GPx associated with diabetes mellitus
7) Confidence 0.41 Published 2010 Journal J Nanobiotechnology Section Body Doc Link PMC2914719 Disease Relevance 0.79 Pain Relevance 0.06
In the anti-inflammatory test, AGT (0.5 and 1.0 g/kg) decreased the paw edema at the third, fourth, fifth and sixth hour after lambda-carrageenan administration, and increased the activities of SOD, GPx and GRx in the liver tissue and decreased the MDA level in the edema paw at the third hour after lambda-carrageenan injection.
Positive_regulation (increased) of GPx in paw associated with pressure and volume under development and inflammation
8) Confidence 0.38 Published 2007 Journal J Ethnopharmacol Section Abstract Doc Link 17616291 Disease Relevance 0.84 Pain Relevance 0.55
The anti-inflammatory mechanism of AGT might be related to the decrease in the level of MDA in the edema paw via increasing the activities of SOD, GPx and GRx in the liver.
Positive_regulation (increasing) of GPx in liver associated with pressure and volume under development and inflammation
9) Confidence 0.38 Published 2007 Journal J Ethnopharmacol Section Abstract Doc Link 17616291 Disease Relevance 0.86 Pain Relevance 0.52
The counterpart of catalase in the mitochondria, GPX, is increased in dwarf mouse kidney and liver tissue as is SOD2 (Brown-Borg and Rakoczy 2000 and unpublished data).
Positive_regulation (increased) of GPX in liver
10) Confidence 0.37 Published 2006 Journal Age (Dordr) Section Body Doc Link PMC2464727 Disease Relevance 0.36 Pain Relevance 0
Furthermore, GPx plasma activity was also significantly increased following thrombolysis.
Positive_regulation (increased) of GPx in plasma
11) Confidence 0.34 Published 1995 Journal Free Radic. Biol. Med. Section Abstract Doc Link 8582662 Disease Relevance 0.55 Pain Relevance 0.07
The significant increase in glutathione peroxidase (Gpx) activity following APAP administration, and the beneficial effects of MnTBAP suggested that ROS were produced during APAP-induced ALF.
Positive_regulation (increase) of Gpx associated with paracetamol and acute liver failure
12) Confidence 0.34 Published 2001 Journal Hepatology Section Abstract Doc Link 11343246 Disease Relevance 0.94 Pain Relevance 0.93
However, Se supplementation rendered significant increase in GPx activity under DMSO (33.1 ± 6.5 mU) and Rot (26.4 ± 5.7 mU) treatments.
Positive_regulation (increase) of GPx
13) Confidence 0.33 Published 2007 Journal International Journal of Biological Sciences Section Body Doc Link PMC1925139 Disease Relevance 0.05 Pain Relevance 0
Selenium supplementation increased glutathione levels and GPx1 activity in HT22 cells, may have a protective role in rotenone-induced oxidative stress.



Positive_regulation (increased) of GPx1 associated with stress
14) Confidence 0.33 Published 2007 Journal International Journal of Biological Sciences Section Body Doc Link PMC1925139 Disease Relevance 0.10 Pain Relevance 0
Therefore, the increased GPx activity after Se supplementation observed in this study is most likely attributable to GPx1, as potentially counteracts the downregulation of GPx1 expression by long-term Rot treatment.

5.

Positive_regulation (attributable) of GPx
15) Confidence 0.28 Published 2007 Journal International Journal of Biological Sciences Section Body Doc Link PMC1925139 Disease Relevance 0.06 Pain Relevance 0
Therefore, the increased GPx activity after Se supplementation observed in this study is most likely attributable to GPx1, as potentially counteracts the downregulation of GPx1 expression by long-term Rot treatment.

5.

Positive_regulation (increased) of GPx
16) Confidence 0.28 Published 2007 Journal International Journal of Biological Sciences Section Body Doc Link PMC1925139 Disease Relevance 0.06 Pain Relevance 0
However, female Wistar rats had higher basal levels of H2O2 production, as well as increased GPx activity in liver mitochondria, compared with their male counterparts [49].
Positive_regulation (increased) of GPx in liver
17) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827549 Disease Relevance 0.32 Pain Relevance 0
Acute estradiol injection caused a significant increase in both MDA levels and GPx activity in liver tissue when compared to the controls, (p <0.05 and p <0.02; respectively).
Positive_regulation (increase) of GPx in liver
18) Confidence 0.24 Published 1999 Journal Res. Commun. Mol. Pathol. Pharmacol. Section Abstract Doc Link 10954129 Disease Relevance 0 Pain Relevance 0.09
We also observed smaller concentrations of circulating GPX and alveolar GPX.
Positive_regulation (circulating) of GPX
19) Confidence 0.21 Published 2001 Journal Anesth. Analg. Section Abstract Doc Link 11574369 Disease Relevance 0.13 Pain Relevance 0.24
We also observed smaller concentrations of circulating GPX and alveolar GPX.
Positive_regulation (circulating) of GPX
20) Confidence 0.18 Published 2001 Journal Anesth. Analg. Section Abstract Doc Link 11574369 Disease Relevance 0.14 Pain Relevance 0.24

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