INT6157

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Context Info
Confidence 0.68
First Reported 1992
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.24
Pain Relevance 0.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Ppia) protein folding (Ppia) cytosol (Ppia)
nucleus (Ppia) cytoplasm (Ppia)
Anatomy Link Frequency
dentate gyrus 1
cerebral cortex 1
hippocampus 1
Ppia (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cerebral cortex 7 99.68 Very High Very High Very High
Enkephalin 3 99.68 Very High Very High Very High
Hippocampus 10 99.40 Very High Very High Very High
Neuropeptide 3 92.84 High High
alcohol 6 24.72 Low Low
Central nervous system 2 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Convulsion 18 99.98 Very High Very High Very High
Fetal Alcohol Syndrome 6 25.52 Quite Low
Apoptosis 19 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 6 5.00 Very Low Very Low Very Low
Death 5 5.00 Very Low Very Low Very Low
Genomic Instability 4 5.00 Very Low Very Low Very Low
Chromosomal Instability 2 5.00 Very Low Very Low Very Low
Aging 2 5.00 Very Low Very Low Very Low
Congenital Anomalies 2 5.00 Very Low Very Low Very Low
Attention Deficit Hyperactivity Disorder 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Limbic seizures increase cyclophilin mRNA levels in rat hippocampus.
Positive_regulation (increase) of cyclophilin mRNA in hippocampus associated with convulsion, enkephalin and hippocampus
1) Confidence 0.68 Published 1992 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 1323013 Disease Relevance 0.37 Pain Relevance 0.32
By nuclease protection analysis a significant increase in cyclophilin mRNA levels was observed in the hippocampal dentate gyrus/CA1 subfield following HL-induced seizures.
Positive_regulation (increase) of cyclophilin mRNA in dentate gyrus associated with convulsion
2) Confidence 0.68 Published 1992 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1323013 Disease Relevance 0.35 Pain Relevance 0.21
Cyclophilin mRNA levels remained stable in the cerebral cortex throughout the same seizure and post-seizure activity time span.
Positive_regulation (stable) of Cyclophilin mRNA in cerebral cortex associated with convulsion and cerebral cortex
3) Confidence 0.49 Published 1992 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1323013 Disease Relevance 0.52 Pain Relevance 0.21
TERT and nestin mRNA levels were quantified by densitometric measurement, and were expressed as a ratio of cyclophilin-A mRNA expression (Molecular Analyst for Windows, BioRad).
Positive_regulation (ratio) of cyclophilin
4) Confidence 0.03 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1249578 Disease Relevance 0 Pain Relevance 0

General Comments

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