INT61570

From wiki-pain
Revision as of 16:54, 22 September 2012 by Daniel (Talk | contribs)

(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to: navigation, search
Context Info
Confidence 0.35
First Reported 1995
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 10
Total Number 11
Disease Relevance 1.62
Pain Relevance 3.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Jun) aging (Jun) nucleus (Jun)
DNA binding (Jun) transcription factor binding (Jun)
Anatomy Link Frequency
spinal cord 4
endothelial cells 2
RMIC 2
molar 2
CNS 2
Jun (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 13 99.88 Very High Very High Very High
electroacupuncture 2 99.80 Very High Very High Very High
Nicotine 10 99.30 Very High Very High Very High
Central nervous system 7 98.48 Very High Very High Very High
nalbuphine 1 97.68 Very High Very High Very High
Spinal cord 11 97.30 Very High Very High Very High
Sciatic nerve 10 96.50 Very High Very High Very High
ischemia 1 96.00 Very High Very High Very High
Eae 2 92.00 High High
Neuropathic pain 3 90.32 High High
Disease Link Frequency Relevance Heat
Injury 19 98.32 Very High Very High Very High
Cv Unclassified Under Development 1 96.00 Very High Very High Very High
Neuropathic Pain 4 90.32 High High
Pain 2 83.12 Quite High
Renal Disease 1 81.00 Quite High
Hyperalgesia 1 80.40 Quite High
Keloid Scars 1 78.72 Quite High
Cancer 9 76.88 Quite High
Necrosis 2 75.76 Quite High
Frailty 1 72.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, PMA caused the induction of c-fos, c-jun and fra-1 mRNA level and, especially, PMA-induced increase of fra-1 mRNA level was further enhanced by CHX treatment at 4 h.
Positive_regulation (induction) of Transcription (level) of c-jun
1) Confidence 0.35 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9555062 Disease Relevance 0 Pain Relevance 0
In addition, CHX alone increased both c-fos and c-jun mRNA levels although the onset times of induction were different.
Positive_regulation (increased) of Transcription (levels) of c-jun
2) Confidence 0.35 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9221929 Disease Relevance 0 Pain Relevance 0.07
KA administration markedly increased both c-fos and c-jun mRNA levels during 1 and 4 h and the increased levels of these proto-oncogene mRNA were further prolonged by the treatment with CHX.
Positive_regulation (increased) of Transcription (levels) of c-jun
3) Confidence 0.35 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9221929 Disease Relevance 0 Pain Relevance 0.07
Additionally, repeated administrations of nicotine transiently induced the c-fos and c-jun mRNA levels after the first-third nicotine administration, and the c-fos and c-jun mRNA levels were returned to the basal level after the seventh administration of nicotine. c-Fos, c-Jun and Fra-2 protein levels were persistently increased until the seventh administration.
Positive_regulation (returned) of Transcription (levels) of c-jun associated with nicotine
4) Confidence 0.34 Published 2002 Journal Life Sci. Section Abstract Doc Link 12269402 Disease Relevance 0 Pain Relevance 0.48
The sciatic nerve and the lumbar tract of the spinal cord were processed to evaluate the levels of the phosphorylated form of PKCgamma, ERK 1,2, SAP/JNK, p-38 and c-Jun; furthermore, the mRNA expression of the early genes c-Jun and c-Fos has been investigated.
Spec (investigated) Positive_regulation (investigated) of Transcription (expression) of c-Jun in spinal cord associated with sciatic nerve and spinal cord
5) Confidence 0.25 Published 2010 Journal Neuroscience Section Abstract Doc Link 19925851 Disease Relevance 0.57 Pain Relevance 0.60
Using the techniques of immunohistochemistry, Northern blotting and in situ hybridization, we have found that electroacupuncture (2/15Hz) accelerated the expression of mRNA and protein synthesis of immediate early genes c-fos, c-jun as well as proenkephalin gene in rat central nervous system (CNS).
Positive_regulation (accelerated) of Transcription (synthesis) of c-jun in CNS associated with central nervous system and electroacupuncture
6) Confidence 0.15 Published 1995 Journal Sheng Li Ke Xue Jin Zhan Section Abstract Doc Link 8584889 Disease Relevance 0 Pain Relevance 0.26
g/mL) caused a 2- to 3-fold increase in induction of AP-1 transcription, whereas dechlorinated products (equivalent molar concentration) had no effect on AP-1–mediated transcription (Mousa et al. 1998).
Positive_regulation (induction) of Transcription (transcription) of AP-1 in molar
7) Confidence 0.15 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1277862 Disease Relevance 0.14 Pain Relevance 0.06
Morphine also enhanced mRNA expression for c-jun and c-myc on RMIC.
Positive_regulation (enhanced) of Transcription (expression) of c-jun in RMIC associated with morphine
8) Confidence 0.15 Published 1997 Journal Nephron Section Abstract Doc Link 9346391 Disease Relevance 0.16 Pain Relevance 1.11
Also, c-Jun protein and mRNA levels are increased
               following blocking axonal transport by peripheral nerve axotomy or spinal cord
               hemisection [19]–[21]. c-Jun is essential for
               axonal regeneration [22]–[24] and may contribute to
               neuropathic pain [25]. 
Positive_regulation (increased) of Transcription (levels) of Jun in spinal cord associated with neuropathic pain and spinal cord
9) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2771921 Disease Relevance 0.53 Pain Relevance 0.25
Confirmation experiments verified that stimulation with beta-endorphin increased the mRNA levels of myelin basic protein, glutathione S-transferase pi, c-junD and rab16 (P < 0.05), genes that are associated with oligodendrogenesis.
Positive_regulation (increased) of Transcription (levels) of c-junD
10) Confidence 0.04 Published 2006 Journal Eur. J. Neurosci. Section Abstract Doc Link 16706836 Disease Relevance 0 Pain Relevance 0.50
Consistent with this idea, it was shown that LDL could induce AP-1 activity in endothelial cells [53] and cholesterol oxide treatment could lead to increased AP-1 DNA binding activity and AP-1 dependent transcription in other cell types [54,55].
Positive_regulation (dependent) of Transcription (transcription) of AP-1 in endothelial cells
11) Confidence 0.02 Published 2001 Journal BMC Pharmacol Section Body Doc Link PMC60650 Disease Relevance 0.22 Pain Relevance 0.04

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox