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Context Info
Confidence 0.72
First Reported 1995
Last Reported 2010
Negated 2
Speculated 3
Reported most in Body
Documents 73
Total Number 76
Disease Relevance 42.04
Pain Relevance 17.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL6) aging (IL6) extracellular region (IL6)
Anatomy Link Frequency
plasma 4
muscle 3
synovial fluid 1
smooth muscle 1
brain 1
IL6 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 1231 100.00 Very High Very High Very High
cytokine 727 100.00 Very High Very High Very High
chemokine 74 100.00 Very High Very High Very High
Osteoarthritis 588 99.84 Very High Very High Very High
Inflammatory mediators 50 99.78 Very High Very High Very High
cINOD 34 99.68 Very High Very High Very High
Neuritis 11 99.62 Very High Very High Very High
rheumatoid arthritis 166 99.60 Very High Very High Very High
Inflammatory response 148 98.50 Very High Very High Very High
Peripheral nervous system 4 98.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1506 100.00 Very High Very High Very High
Osteoarthritis 588 99.84 Very High Very High Very High
Atherosclerosis 470 99.84 Very High Very High Very High
Cancer 406 99.80 Very High Very High Very High
Experimental Autoimmune Neuritis 11 99.62 Very High Very High Very High
Rheumatoid Arthritis 178 99.60 Very High Very High Very High
Anaplastic Astrocytoma 9 99.60 Very High Very High Very High
Necrosis 95 99.56 Very High Very High Very High
Myocardial Infarction 118 99.12 Very High Very High Very High
Renal Cancer 3 98.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The three promoter variations G-597A, G-572C and G-174C have been shown to influence IL-6 transcription through a complex interaction determined by the haplotype, and the G alleles at these loci have been found to associate with increased transcription of IL-6 [16].
Transcription (transcription) of IL-6
1) Confidence 0.72 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374458 Disease Relevance 0.89 Pain Relevance 0.51
The three promoter variations G-597A, G-572C and G-174C have been shown to influence IL-6 transcription through a complex interaction determined by the haplotype, and the G alleles at these loci have been found to associate with increased transcription of IL-6 [16].
Transcription (transcription) of IL-6
2) Confidence 0.72 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374458 Disease Relevance 0.99 Pain Relevance 0.57
There is substantial evidence that the increase in IL-6 serum levels with age results in part from the loss of sex steroids such as estrogen, testosterone and dehydroepiandrosterone [36,37], which have an important role in blocking transcription of the IL-6 gene, so that their loss at menopause may have a more conspicuous role than the genotype.
Transcription (transcription) of IL-6 associated with endometriosis (extended)
3) Confidence 0.72 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374458 Disease Relevance 0.81 Pain Relevance 0.34
This variation regulates the transcription of the IL-6 gene and is associated with plasma levels of IL-6 [15].
Transcription (transcription) of IL-6 in plasma
4) Confidence 0.72 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374458 Disease Relevance 0.63 Pain Relevance 0.30
A significant increase in the level of IL-6 mRNA has been detected in OA-affected cartilage, and the IL-6 levels in the serum and synovial fluid have been reported to be elevated among OA patients [12].
Transcription (level) of IL-6 in synovial fluid associated with osteoarthritis
5) Confidence 0.72 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374458 Disease Relevance 1.31 Pain Relevance 0.61
Serum interleukin-6 levels measured during admission had been elevated, and interleukin-6 mRNA was detected in the autopsy specimen of renal cell carcinoma.
Transcription (detected) of interleukin-6 associated with renal cancer
6) Confidence 0.70 Published 2001 Journal Intern. Med. Section Abstract Doc Link 11579958 Disease Relevance 0.86 Pain Relevance 0.18
In the present study a positive correlation between circulating IL-6 and muscle IL-6 mRNA expression was observed (Fig. 1c), suggesting that muscle-derived IL-6 protein may be released into circulation accounting for the rise in plasma IL-6.
Transcription (expression) of IL-6 in plasma
7) Confidence 0.69 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2696599 Disease Relevance 0.06 Pain Relevance 0
In the present study a positive correlation between circulating IL-6 and muscle IL-6 mRNA expression was observed (Fig. 1c), suggesting that muscle-derived IL-6 protein may be released into circulation accounting for the rise in plasma IL-6.
Transcription (expression) of IL-6 in plasma
8) Confidence 0.69 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2696599 Disease Relevance 0.06 Pain Relevance 0
Serum IL-6 was strongly correlated to the increase in muscle IL-6 mRNA (r2?
Transcription (mRNA) of IL-6 in muscle
9) Confidence 0.66 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2696599 Disease Relevance 0.06 Pain Relevance 0
study, the concentrations of IL-6 in the symptomatic lesions were
Transcription (concentrations) of IL-6
10) Confidence 0.65 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC1804300 Disease Relevance 0.59 Pain Relevance 0.29
Simultaneous addition of IL-1alpha and PGE2 or TNF-alpha and PGE2 to the cultures significantly reduced the cytokine-induced IL-6 mRNA synthesis ranging from 45% to 65%.
Transcription (synthesis) of IL-6 in PGE2 associated with cytokine
11) Confidence 0.64 Published 2002 Journal J Endod Section Abstract Doc Link 12017180 Disease Relevance 0.41 Pain Relevance 0.30
Ang II significantly increased the expression of IL-6 mRNA and protein in a dose-dependent manner (10(-10) to 10(-6) mol/L).
Transcription (expression) of IL-6
12) Confidence 0.62 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0.49 Pain Relevance 0.07
Ang II significantly increases the expression of IL-6 mRNA and protein in vascular smooth muscle, in a dose-dependent manner.
Transcription (expression) of IL-6 in smooth muscle
13) Confidence 0.62 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0.50 Pain Relevance 0
AP-1 activity plays an important role in the inflammatory response by modulating gene expression of several inflammatory mediators including IL-6 transcription.
Transcription (transcription) of IL-6 associated with inflammatory mediators and inflammatory response
14) Confidence 0.62 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0.28 Pain Relevance 0.10
Additional clues came from the observations that menopause or ovariectomy resulted in increased IL-6 serum levels [153], increased IL-6 mRNA levels in bone cells [154], and increased IL-6 secretion by mononuclear cells [155-157].
Transcription (levels) of IL-6 in mononuclear cells associated with endometriosis (extended)
15) Confidence 0.62 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 1.37 Pain Relevance 0.07
The expression of IL-6 mRNA induced by Ang II was completely blocked by an Ang II type 1 receptor antagonist, CV11974.
Transcription (expression) of IL-6 associated with antagonist
16) Confidence 0.62 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0.50 Pain Relevance 0.08
In one study Ang II treatment induced IL-6 transcription by inducing cytoplasmic-to-nuclear translocation of the NF-kappaB subunits Rel A and NF-kappaB1 with parallel changes in DNA-binding activity in a biphasic manner, which produced an early peak at 15 minutes followed by a nadir 1 to 6 hours later and a later peak at 24 hours [60].


Transcription (transcription) of IL-6
17) Confidence 0.59 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0.20 Pain Relevance 0.10
Although mRNA could be detected for IL-1, IL-6, iNOS and cox-2 in some of the samples, mean cycle numbers were very high and thus, have to be interpreted with caution. mRNA of iNOS and IL-6 were detected in almost all samples, while IL-1 and PGE2 were found in only very few samples.


Transcription (detected) of IL-6
18) Confidence 0.58 Published 2004 Journal BMC Musculoskelet Disord Section Body Doc Link PMC404466 Disease Relevance 0 Pain Relevance 0.03
This was reflected also with the numbers of cycles for IL-1, IL-6, iNOS and cox-2, although mRNA of IL-6 and iNOS were at least detected in most of the groups.
Transcription (detected) of IL-6
19) Confidence 0.56 Published 2004 Journal BMC Musculoskelet Disord Section Body Doc Link PMC404466 Disease Relevance 0.07 Pain Relevance 0
Although mRNA could be detected for IL-1, IL-6, iNOS and cox-2 in some of the samples, mean cycle numbers were very high and thus, have to be interpreted with caution. mRNA of iNOS and IL-6 were detected in almost all samples, while IL-1 and PGE2 were found in only very few samples.


Transcription (interpreted) of IL-6
20) Confidence 0.56 Published 2004 Journal BMC Musculoskelet Disord Section Body Doc Link PMC404466 Disease Relevance 0 Pain Relevance 0.03

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