INT6177

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Context Info
Confidence 0.47
First Reported 1987
Last Reported 2009
Negated 2
Speculated 1
Reported most in Abstract
Documents 65
Total Number 66
Disease Relevance 17.65
Pain Relevance 30.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Htr1a) signal transducer activity (Htr1a)
Anatomy Link Frequency
brain 11
hippocampus 4
frontal cortex 3
Semen 2
dorsal 2
Htr1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 101 100.00 Very High Very High Very High
antidepressant 91 100.00 Very High Very High Very High
Sumatriptan 24 100.00 Very High Very High Very High
Serotonin 42 99.98 Very High Very High Very High
positron emission tomography 4 99.96 Very High Very High Very High
monoamine 11 99.82 Very High Very High Very High
Raphe 26 99.80 Very High Very High Very High
fluoxetine 170 99.76 Very High Very High Very High
Pain 7 99.76 Very High Very High Very High
Hippocampus 50 99.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 6 99.76 Very High Very High Very High
Urological Neuroanatomy 26 99.68 Very High Very High Very High
Stress 121 99.58 Very High Very High Very High
Depression 114 99.48 Very High Very High Very High
Nociception 4 99.28 Very High Very High Very High
Anxiety Disorder 17 97.98 Very High Very High Very High
Hypoglycemia 60 97.24 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

5 96.00 Very High Very High Very High
Sprains And Strains 5 95.44 Very High Very High Very High
Hyperalgesia 3 95.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is concluded that [3H]5-CT, in the presence of selective blockers, can be used to investigate the properties of 5-HT1A, 5-HT1B/1D and 5-HT7 receptors in the rodent brain, although further studies are required to explain the atypical features of [3H]5-CT binding in 5-HT1A receptors containing regions.
5-HT1A Binding (binding) of in brain
1) Confidence 0.47 Published 1995 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7498319 Disease Relevance 0 Pain Relevance 0.10
The similar stimulus properties of 8-OHDPAT and the novel anxiolytics (buspirone, ipsapirone) are mirrored by the common abilities of these agents to selectively inhibit 5-HT1A binding and release punished responding.
5-HT1A Binding (binding) of associated with anxiety disorder
2) Confidence 0.47 Published 1987 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2887435 Disease Relevance 0.34 Pain Relevance 0.40
This reversal effect of N.s. on the decrease in 5-HT1A receptor binding in the frontal cortex, hippocampus and hypothalamus of rat brains was very similar to that of H.p, but different from that of F.
5-HT1A Binding (binding) of in brains associated with urological neuroanatomy and hippocampus
3) Confidence 0.47 Published 2004 Journal Arch. Pharm. Res. Section Abstract Doc Link 15554266 Disease Relevance 1.25 Pain Relevance 0.32
In the CA2 and CA3 regions of the hippocampus, both N.s. and H.p. reversed the CMS-induced decrease in 5-HT1A receptor binding.
5-HT1A Binding (binding) of in hippocampus associated with stress and hippocampus
4) Confidence 0.47 Published 2004 Journal Arch. Pharm. Res. Section Abstract Doc Link 15554266 Disease Relevance 1.64 Pain Relevance 0.46
Both 5-HT1 and 5-HT2 receptors are involved, and there was a functional interaction between 5-HT1A and 5-HT2A or 5-HT2C receptors, as ritanserin potentiated the antiaggressive effect of 1,5-HTP as well as that of 8-OH-DPAT.
5-HT1A Binding (interaction) of
5) Confidence 0.47 Published 1997 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 9084057 Disease Relevance 0.44 Pain Relevance 0.39
The present study assessed if Nelumbinis Semen (N.s.) had an anti-depression effect through reversing a decrease in 5-HT1A receptor binding in rats with depression-like symptoms induced by chronic mild stress.
5-HT1A Binding (binding) of in Semen associated with stress and depression
6) Confidence 0.47 Published 2004 Journal Arch. Pharm. Res. Section Abstract Doc Link 15554266 Disease Relevance 0.94 Pain Relevance 0.46
Nelumbinis Semen reverses a decrease in 5-HT1A receptor binding induced by chronic mild stress, a depression-like symptom.
5-HT1A Binding (binding) of in Semen associated with stress and depression
7) Confidence 0.47 Published 2004 Journal Arch. Pharm. Res. Section Title Doc Link 15554266 Disease Relevance 1.05 Pain Relevance 0.50
In the I to II regions of the frontal cortex, N.s. and H.p. also reversed the CMS-induced decrease in 5-HT1A receptor binding, and even showed a significant increase in 5-HT1A receptor binding compared to the F treatment group (N.s. vs.
5-HT1A Binding (binding) of in frontal cortex associated with stress and urological neuroanatomy
8) Confidence 0.47 Published 2004 Journal Arch. Pharm. Res. Section Abstract Doc Link 15554266 Disease Relevance 1.49 Pain Relevance 0.42
[The alpha-antiadrenergic properties of spiroxatrine, a ligand of serotonergic 5-HT1A receptors].
5-HT1A Binding (ligand) of
9) Confidence 0.47 Published 1993 Journal Arch Inst Cardiol Mex Section Title Doc Link 8105762 Disease Relevance 0 Pain Relevance 0.27
In the I to II regions of the frontal cortex, N.s. and H.p. also reversed the CMS-induced decrease in 5-HT1A receptor binding, and even showed a significant increase in 5-HT1A receptor binding compared to the F treatment group (N.s. vs.
5-HT1A Binding (binding) of in frontal cortex associated with stress and urological neuroanatomy
10) Confidence 0.47 Published 2004 Journal Arch. Pharm. Res. Section Abstract Doc Link 15554266 Disease Relevance 1.42 Pain Relevance 0.42
It is concluded that N.s. presents an anti-depression effect through enhancing 5-HT1A receptor binding.
5-HT1A Binding (binding) of associated with depression
11) Confidence 0.47 Published 2004 Journal Arch. Pharm. Res. Section Abstract Doc Link 15554266 Disease Relevance 1.07 Pain Relevance 0.26
Simultaneous administration of alpha 2-adrenergic agents with LSD shifted the dose-response curve to the left only when the adrenergic agent also possessed at least moderate affinity for the 5-HT1A receptor.
5-HT1A Binding (affinity) of
12) Confidence 0.47 Published 1995 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 8539318 Disease Relevance 0 Pain Relevance 0.61
The 5-HT1A and 5-HT3 agonists, 8-OH-DPAT and 2-methyl-5-HT, respectively, produced only transient responses by themselves and did not interact with PGE2 or NA.
5-HT1A Binding (interact) of in PGE2 associated with noradrenaline and agonist
13) Confidence 0.47 Published 1996 Journal Neuropharmacology Section Abstract Doc Link 8684602 Disease Relevance 0.48 Pain Relevance 0.89
However, in the hypothalamus, all treatments reversed the CMS-induced decrease in 5-HT1A receptor binding.
5-HT1A Binding (binding) of in hypothalamus associated with stress
14) Confidence 0.47 Published 2004 Journal Arch. Pharm. Res. Section Abstract Doc Link 15554266 Disease Relevance 1.28 Pain Relevance 0.35
In parallel experiments, the kinetics of in vivo binding of the 5-HT1A positron emission tomography radioligand 4,2-(methoxyphenyl)-1-[2-(N-2-pyridinyl)-p-fluorobenzamido]ethylpiperazine ([18F]MPPF) was measured in these two brain regions by means of stereotaxically implanted beta microprobes.
5-HT1A Binding (binding) of in brain associated with positron emission tomography
15) Confidence 0.47 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15190115 Disease Relevance 0 Pain Relevance 0.66
These compounds have high affinity for 5-HT1A and 5-HT1D receptors.
5-HT1A Binding (affinity) of
16) Confidence 0.47 Published 1992 Journal Life Sci. Section Abstract Doc Link 1325017 Disease Relevance 0 Pain Relevance 0.29
Abstinence from U-50,488H, a kappa-opiate receptor agonist, decreases the binding of [3H]DPAT to 5-HT1A receptors in the hypothalamus of the rat.
5-HT1A Binding (binding) of in hypothalamus associated with agonist and opiate
17) Confidence 0.47 Published 1992 Journal Neuropharmacology Section Title Doc Link 1470300 Disease Relevance 0 Pain Relevance 0.70
By contrast, neither amoxapine nor amitriptyline can be considered as possible ligands of 5-HT1A and 5-HT1B receptors because their affinities for these sites are in the micromolar range (or even worse).
5-HT1A Binding (ligands) of associated with endep
18) Confidence 0.47 Published 1991 Journal Encephale Section Abstract Doc Link 1666997 Disease Relevance 0 Pain Relevance 0.33
Therefore, most imidazoline drugs modulated the synthesis of brain monoamines through interaction with alpha2-adrenoceptors or 5-HT1A receptors.
5-HT1A Binding (interaction) of in brain associated with monoamine
19) Confidence 0.47 Published 1999 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 10463334 Disease Relevance 0 Pain Relevance 0.38
These results suggest that certain opioid narcotics, disrupt serotonergic neurotransmission as a result of direct interactions with 5-HT1A receptors.
5-HT1A Binding (interactions) of associated with opioid
20) Confidence 0.47 Published 1991 Journal Neuropharmacology Section Abstract Doc Link 1830134 Disease Relevance 0 Pain Relevance 0.49

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