INT61822

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Context Info
Confidence 0.41
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 5.33
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ocln) structural molecule activity (Ocln) plasma membrane (Ocln)
Anatomy Link Frequency
long bones 2
vertebrae 2
Ocln (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 55 97.80 Very High Very High Very High
Crohn's disease 4 91.40 High High
Inflammation 100 85.04 High High
cytokine 21 76.88 Quite High
cva 1 75.56 Quite High
Pain 4 29.80 Quite Low
chemokine 3 24.56 Low Low
imagery 12 5.00 Very Low Very Low Very Low
Inflammatory response 6 5.00 Very Low Very Low Very Low
fibrosis 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colitis 31 97.90 Very High Very High Very High
Apoptosis 73 96.84 Very High Very High Very High
Disease 39 91.40 High High
Hypercalcemia 32 89.12 High High
Weight Loss 2 87.28 High High
Injury 10 85.88 High High
INFLAMMATION 103 85.04 High High
Alopecia 3 83.68 Quite High
Pulmonary Disease 34 81.72 Quite High
Asthma 39 81.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is even possible that apical epithelial junction proteins including occludin can be reduced without undue effects on epithelial barrier function.
Negative_regulation (reduced) of occludin
1) Confidence 0.41 Published 2010 Journal Respir Res Section Body Doc Link PMC2900258 Disease Relevance 0.45 Pain Relevance 0.03
Furthermore, while we observed decreases in microvessel occludin following VP2121–130 peptide administration, Claudin-5 levels dramatically increased.
Negative_regulation (decreases) of occludin
2) Confidence 0.19 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516328 Disease Relevance 0.49 Pain Relevance 0.14
Histologic examination of tissues from the ARH-77 mice showed infiltration of myeloma cells in the liver and spleen and marked infiltration in vertebrae and long bones, with loss of bony trabeculae and increased OCL numbers.
Negative_regulation (numbers) of OCL in long bones
3) Confidence 0.14 Published 1996 Journal Blood Section Abstract Doc Link 8608240 Disease Relevance 0.82 Pain Relevance 0.04
Histologic examination of tissues from the ARH-77 mice showed infiltration of myeloma cells in the liver and spleen and marked infiltration in vertebrae and long bones, with loss of bony trabeculae and increased OCL numbers.
Negative_regulation (loss) of OCL in long bones
4) Confidence 0.14 Published 1996 Journal Blood Section Abstract Doc Link 8608240 Disease Relevance 0.83 Pain Relevance 0.04
Moreover, using a mouse colitis model, Resta-Lenert et al. have shown that the increase in intestinal permeability is associated with a decrease of occludin and ZO-1 phosphorylation [54].
Negative_regulation (decrease) of occludin associated with colitis
5) Confidence 0.12 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2110898 Disease Relevance 0.77 Pain Relevance 0.07
Western blot analysis of epidermal lysates confirmed the down-regulation of claudin 3 and occludin at the protein level and also revealed reduced claudin-1 expression in K5-R1/R2 mice (Fig. 8 C).
Negative_regulation (down-regulation) of occludin
6) Confidence 0.08 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2845079 Disease Relevance 0.31 Pain Relevance 0.04
Histologic examination of tissues from the ARH-77 mice showed infiltration of myeloma cells in the liver and spleen and marked infiltration in vertebrae and long bones, with loss of bony trabeculae and increased OCL numbers.
Negative_regulation (loss) of OCL in vertebrae
7) Confidence 0.05 Published 1996 Journal Blood Section Abstract Doc Link 8608240 Disease Relevance 0.83 Pain Relevance 0.04
Histologic examination of tissues from the ARH-77 mice showed infiltration of myeloma cells in the liver and spleen and marked infiltration in vertebrae and long bones, with loss of bony trabeculae and increased OCL numbers.
Negative_regulation (numbers) of OCL in vertebrae
8) Confidence 0.05 Published 1996 Journal Blood Section Abstract Doc Link 8608240 Disease Relevance 0.82 Pain Relevance 0.04

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