INT61865

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Context Info
Confidence 0.19
First Reported 1996
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.02
Pain Relevance 3.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Vta1)
Anatomy Link Frequency
striatum 2
Vta1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Ventral tegmentum 146 100.00 Very High Very High Very High
depression 89 100.00 Very High Very High Very High
gABA 20 100.00 Very High Very High Very High
Glutamate receptor 4 99.04 Very High Very High Very High
Desipramine 1 98.84 Very High Very High Very High
Morphine 8 96.52 Very High Very High Very High
cocaine 18 96.32 Very High Very High Very High
Glutamate 11 92.76 High High
Dopamine 67 91.44 High High
Cannabinoid 54 88.96 High High
Disease Link Frequency Relevance Heat
Depression 89 100.00 Very High Very High Very High
Stress 7 96.76 Very High Very High Very High
Li-fraumeni Syndrome 16 77.44 Quite High
Drug Dependence 7 5.00 Very Low Very Low Very Low
Cannabis Dependence 4 5.00 Very Low Very Low Very Low
Anxiety Disorder 4 5.00 Very Low Very Low Very Low
Recurrence 4 5.00 Very Low Very Low Very Low
Sprains And Strains 1 5.00 Very Low Very Low Very Low
Cognitive Disorder 1 5.00 Very Low Very Low Very Low
Mental Disorders 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We observed the pattern of c-Fos expression in the VTA and the ventral striatum paralleled with the connectivity between the VTA and ventral striatum.
Regulation (pattern) of Gene_expression (expression) of VTA in striatum associated with ventral tegmentum
1) Confidence 0.19 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2930627 Disease Relevance 0 Pain Relevance 0.38
In contrast, intra-mPfc TTX decreased local GABA (-33+6%) while VTA GABA levels were not affected.
Neg (not) Regulation (affected) of Gene_expression (levels) of VTA associated with ventral tegmentum and gaba
2) Confidence 0.16 Published 2002 Journal J. Neurosci. Methods Section Abstract Doc Link 12323414 Disease Relevance 0 Pain Relevance 1.13
To further test this hypothesis, we applied TAT-GluR2 peptide to block HU210-induced LTD in vivo, and then examined whether this blockade would result in prevention of HU210-facilitated VTA LTD induction in vitro 24 h after the fifth HU210 injection.
Regulation (facilitated) of Gene_expression (induction) of VTA associated with ventral tegmentum and depression
3) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004941 Disease Relevance 0.62 Pain Relevance 0.63
Unlike cocaine, morphine, and stress, repeated treatment with other psychotropic drugs (haloperidol, raclopride, sertraline, and desipramine) that lack reinforcing or sensitizing properties did not regulate GluR1 or NMDAR1 subunit levels in the VTA.
Neg (not) Regulation (regulate) of Gene_expression (levels) of VTA associated with stress, ventral tegmentum, desipramine, morphine and cocaine
4) Confidence 0.11 Published 1996 Journal J. Neurosci. Section Abstract Doc Link 8613793 Disease Relevance 0.40 Pain Relevance 1.04

General Comments

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