INT61866

Context Info Confidence 0.36 First Reported 1996 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 6 Total Number 9 Disease Relevance 5.02 Pain Relevance 7.88

cytoplasm (Vta1)

Anatomy Link Frequency DA neurons 2 tail 2 dopamine neurons 2 Vta1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Ventral tegmentum 474 100.00 depression 362 100.00 Dopamine 200 100.00 Glutamate receptor 9 100.00 Cannabinoid 216 99.98 gABA 48 99.96 Morphine 24 98.88 Eae 17 97.80 long-term potentiation 96 96.96 Nicotine 66 96.12

Disease Link Frequency Relevance Heat Depression 362 100.00 Li-fraumeni Syndrome 64 100.00 Cold Sores 8 100.00 Herpes Simplex Virus 5 99.62 Stress 19 98.84 Nociception 1 96.00 Drug Dependence 24 5.00 Cannabis Dependence 16 5.00 Anxiety Disorder 16 5.00 Recurrence 16 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Identifying precisely how these lesions influence the dynamics of neuronal interactions in the VTA—do they affect a direct nicotinic activation of DA neurons or is the effect mediated through GABA?

Positive_regulation (through) of Gene_expression (do) of VTA in DA neurons associated with ventral tegmentum, gaba and dopamine

1) Confidence 0.36 Published 2008 Journal Brain Struct Funct Section Body Doc Link PMC2522332 Disease Relevance 0 Pain Relevance 0.60

Microinjections of a herpes simplex virus (HSV) vector that causes local overexpression of GluR1 (HSV-GluR1) into the VTA can enhance the ability of morphine to establish conditioned place preferences, suggesting that altered GluR1 expression in this region is directly associated with changes in the rewarding efficacy of morphine.

Positive_regulation (overexpression) of Gene_expression (overexpression) of VTA associated with ventral tegmentum, cold sores, herpes simplex virus and morphine

2) Confidence 0.22 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 10684909 Disease Relevance 0.45 Pain Relevance 1.01

Microinjections of a herpes simplex virus (HSV) vector that causes local overexpression of GluR1 (HSV-GluR1) into the VTA can enhance the ability of morphine to establish conditioned place preferences, suggesting that altered GluR1 expression in this region is directly associated with changes in the rewarding efficacy of morphine.

Positive_regulation (causes) of Gene_expression (overexpression) of VTA associated with ventral tegmentum, cold sores, herpes simplex virus and morphine

3) Confidence 0.22 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 10684909 Disease Relevance 0.45 Pain Relevance 1.01

Increased glutamate receptor subunit expression in the VTA may represent an important molecular mechanism by which drugs of abuse and stress exert common, long-term effects on mesolimbic DA function.

Positive_regulation (Increased) of Gene_expression (expression) of VTA associated with stress, ventral tegmentum, dopamine and glutamate receptor

4) Confidence 0.19 Published 1996 Journal J. Neurosci. Section Abstract Doc Link 8613793 Disease Relevance 0.49 Pain Relevance 1.00

Second, the AMPAR/NMDAR ratio of glutamatergic synaptic currents in VTA dopamine neurons was significantly smaller at 30 min (0.44±0.05; n?

Positive_regulation (/) of Gene_expression (dopamine neurons) of VTA in dopamine neurons associated with ventral tegmentum and dopamine

5) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004941 Disease Relevance 0.75 Pain Relevance 0.92

To determine whether systemically applied TAT-GluR2 peptide disrupted CPP acquisition by its action in the VTA, we conducted intra-VTA infusion of the peptide (15 pmol) 60 min before each HU210 injection during conditioning (Figure 6B).

Positive_regulation (conducted) of Gene_expression (infusion) of intra-VTA associated with ventral tegmentum

6) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004941 Disease Relevance 0.38 Pain Relevance 0.63

The pivotal role of GluR2 endocytosis in cannabinoid-facilitated LTD expression in the VTA is supported by our findings that bath application of TAT-GluR2, but not its scrambled sequence, blocked LTD expression in HU210-treated rats (Figure 4C,D).

Positive_regulation (facilitated) of Gene_expression (expression) of VTA associated with ventral tegmentum, depression and cannabinoid

7) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004941 Disease Relevance 0.68 Pain Relevance 1.25

After a bilateral injection of the vectors into the major part of the VTA (Figure 2B), the CB1R shRNA, but not its scrambled sequence, significantly suppressed CB1R expression in the VTA (Figure 2C) and LFS-induced LTD in HU210-treated rats (Figure 2D,E).

Positive_regulation (induced) of Gene_expression (expression) of VTA associated with ventral tegmentum, li-fraumeni syndrome and depression

8) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004941 Disease Relevance 0.96 Pain Relevance 1.15

Using herpes simplex virus-mediated gene transfer to assess the functional significance of this ERK induction, we show that overexpressing ERK2 within the VTA increases susceptibility to stress as measured in the forced swim test, responses to unconditioned nociceptive stimuli, and elevated plus maze in Sprague Dawley male rats, and in the tail suspension test and chronic social defeat stress procedure in C57BL/6 male mice.

Positive_regulation (overexpressing) of Gene_expression (overexpressing) of VTA in tail associated with nociception, stress, ventral tegmentum, herpes simplex virus and eae

9) Confidence 0.11 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20519540 Disease Relevance 0.85 Pain Relevance 0.32

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