INT61986

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Context Info
Confidence 0.69
First Reported 1996
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 16
Total Number 16
Disease Relevance 2.12
Pain Relevance 5.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Creb1) mitochondrion (Creb1) nucleolus (Creb1)
nucleus (Creb1) DNA binding (Creb1) transcription factor binding (Creb1)
Anatomy Link Frequency
neurons 2
plasma 1
synovial cells 1
dorsal horn 1
cortex 1
Creb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 74 100.00 Very High Very High Very High
Morphine 28 99.68 Very High Very High Very High
withdrawal 20 99.62 Very High Very High Very High
dorsal root ganglion 8 99.32 Very High Very High Very High
Kinase C 8 98.70 Very High Very High Very High
spinal dorsal horn 6 98.32 Very High Very High Very High
nMDA receptor antagonist 6 97.44 Very High Very High Very High
long-term potentiation 17 97.32 Very High Very High Very High
narcan 5 96.88 Very High Very High Very High
Glutamate 48 91.64 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 44 99.32 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 2 96.68 Very High Very High Very High
Stress 118 89.80 High High
Apoptosis 64 89.52 High High
Hypoxia 7 87.48 High High
Urological Neuroanatomy 95 86.40 High High
Pain 6 82.16 Quite High
Cold Sores 21 81.44 Quite High
Neuroblastoma 18 80.00 Quite High
Injury 48 64.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, PKC inhibitor calphostin C reduced the withdrawal-triggered rise in pCREB, pERK(1/2), TH expression and corticosterone secretion.
Localization (secretion) of pCREB associated with kinase c and withdrawal
1) Confidence 0.69 Published 2009 Journal J. Neurochem. Section Abstract Doc Link 19545278 Disease Relevance 0.16 Pain Relevance 1.14
Double-labeling experiments showed that pCREB was colocalized with PDYN, PENK, or TH mRNA in the AVPV, suggesting that pCREB may mediate the effect of steroid hormones on gene expression in these neurons.
Localization (colocalized) of pCREB in neurons
2) Confidence 0.65 Published 1996 Journal J. Neurosci. Section Abstract Doc Link 8622133 Disease Relevance 0 Pain Relevance 0.04
predator stressed and Handled CREB rats exhibited more pCREB lir in the right over the left (all t, P < .04,
Localization (lir) of pCREB
3) Confidence 0.65 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2664642 Disease Relevance 0.38 Pain Relevance 0.11
Furthermore, colocalization of the NR1 subunit of the NMDA receptor and P-CREB was demonstrated by double immunolabeling with both antibodies (Figure 3F).
Localization (colocalization) of P-CREB associated with nmda receptor
4) Confidence 0.64 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2666774 Disease Relevance 0 Pain Relevance 0.32
Similarly, coimmunolabeling demonstrated colocalization of the progenitor marker nestin and P-CREB on the same cell, although with a different subcellular localization (Figure 3G).
Localization (colocalization) of P-CREB
5) Confidence 0.64 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2666774 Disease Relevance 0 Pain Relevance 0.29
Double immunostaining showed that after LTP induction, most pERK was co-localized with pCREB.
Localization (localized) of pCREB
6) Confidence 0.62 Published 2009 Journal Neurosci Bull Section Body Doc Link 19784086 Disease Relevance 0.06 Pain Relevance 0
SL327, an inhibitor of ERK activation, at doses which reduced the hyperactive pERK(1/2) levels, did not attenuated the rise in pCREB and TH immunoreactivity or plasma corticosterone secretion during morphine withdrawal, indicating that ERK kinase/ERK pathway was not directly needed for either activation of CREB and TH expression in the NTS or HPA axis hyperactivity.
Localization (secretion) of pCREB in plasma associated with attention deficit hyperactivity disorder, withdrawal and morphine
7) Confidence 0.61 Published 2009 Journal J. Neurochem. Section Abstract Doc Link 19545278 Disease Relevance 0.23 Pain Relevance 1.22
The number of neurons expressing phosphorylated cAMP responsive element binding protein (pCREB) was also markedly increased in morphine-exposed cultured DRG neurons. pERK-, pP38-, pJNK- and pCREB-IR were colocalized with CGRP-IR in cultured DRG neurons.
Localization (colocalized) of pCREB in neurons associated with dorsal root ganglion and morphine
8) Confidence 0.59 Published 2001 Journal Eur. J. Neurosci. Section Abstract Doc Link 11683901 Disease Relevance 0.69 Pain Relevance 1.53
In contrast, Ca2+ delivered by surface membrane influx evoked a strong pCREB response (Fig. 4 F, left).
Localization (response) of pCREB
9) Confidence 0.51 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2592819 Disease Relevance 0 Pain Relevance 0.03
The relationship between pCREB and stimulus time as a readout of signal strength
Localization (relationship) of pCREB
10) Confidence 0.51 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2592819 Disease Relevance 0 Pain Relevance 0
-cells, K+ fluxes via nuclear KATP channels release Ca2+ stored in the nuclear envelope leading to CREB phosphorylation and gene expression [47].
Localization (release) of CREB
11) Confidence 0.36 Published 2010 Journal Mol Pain Section Body Doc Link PMC2825500 Disease Relevance 0 Pain Relevance 0
When both WOX1 and CREB were colocalized in the nuclei, their
                   binding was significantly greater than in the cytoplasm (Fig. 6B, E). 
Localization (colocalized) of CREB
12) Confidence 0.29 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2771921 Disease Relevance 0.27 Pain Relevance 0
Double immunofluorescence staining showed that p-ERK and p-CREB were only located in neurons but not in glial cells in the spinal dorsal horn after LTP induction.
Neg (not) Localization (located) of p-CREB in dorsal horn associated with spinal dorsal horn and long-term potentiation
13) Confidence 0.27 Published 2006 Journal J. Neurosci. Res. Section Abstract Doc Link 16902997 Disease Relevance 0.08 Pain Relevance 0.94
The nuclear accumulation of p-CREB
                   reached maximally 24 hours after axotomy, followed by disappearance.
Localization (accumulation) of p-CREB
14) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2771921 Disease Relevance 0.14 Pain Relevance 0
In this study, we ask: Are activated forms of ERK, RSK, and CREB colocalized in the cortex and are they coordinately regulated by synaptic signals?
Localization (colocalized) of CREB in cortex
15) Confidence 0.18 Published 2004 Journal J. Comp. Neurol. Section Abstract Doc Link 15389611 Disease Relevance 0 Pain Relevance 0.03
The opioid peptides inhibited nuclear translocation and phosphorylation of the transcription factor, cyclic AMP responsive element binding protein (CREB) in RA synovial cells.
Localization (translocation) of CREB in synovial cells
16) Confidence 0.04 Published 2001 Journal J. Rheumatol. Section Body Doc Link 11669152 Disease Relevance 0.11 Pain Relevance 0

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