INT62132

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Context Info
Confidence 0.62
First Reported 1996
Last Reported 2002
Negated 4
Speculated 2
Reported most in Abstract
Documents 12
Total Number 13
Disease Relevance 1.28
Pain Relevance 4.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ifng) extracellular region (Ifng)
Anatomy Link Frequency
gonadal 6
sympathetic 4
macrophage 2
splenic macrophages 2
B cells 2
Ifng (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 42 100.00 Very High Very High Very High
Pain 14 100.00 Very High Very High Very High
Lasting pain 4 100.00 Very High Very High Very High
Inflammation 1 93.00 High High
withdrawal 1 91.00 High High
antinociception 3 89.32 High High
cytokine 4 88.20 High High
medulla 2 85.00 Quite High
Antinociceptive 4 76.60 Quite High
Intracerebroventricular 3 75.00 Quite High
Disease Link Frequency Relevance Heat
Pain 14 100.00 Very High Very High Very High
Cancer 1 100.00 Very High Very High Very High
Necrosis 1 100.00 Very High Very High Very High
INFLAMMATION 1 93.00 High High
Asthma 2 81.96 Quite High
Nicotine Addiction 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The role of gonadal hormones and persistent pain (formalin test) in the regulation of interferon-gamma (IFN-gamma) production in splenocytes was investigated in male and female rats.
Spec (investigated) Regulation (role) of Gene_expression (production) of IFN-gamma in gonadal associated with pain and lasting pain
1) Confidence 0.62 Published 2001 Journal Brain Behav. Immun. Section Abstract Doc Link 11566050 Disease Relevance 0.17 Pain Relevance 0.17
Effects of gonadectomy and pain on interferon-gamma production in splenocytes of male and female rats.
Regulation (Effects) of Gene_expression (production) of interferon-gamma associated with pain
2) Confidence 0.62 Published 2001 Journal Brain Behav. Immun. Section Title Doc Link 11566050 Disease Relevance 0.20 Pain Relevance 0.30
The role of gonadal hormones and persistent pain (formalin test) in the regulation of interferon-gamma (IFN-gamma) production in splenocytes was investigated in male and female rats.
Regulation (regulation) of Gene_expression (production) of interferon-gamma in gonadal associated with pain and lasting pain
3) Confidence 0.45 Published 2001 Journal Brain Behav. Immun. Section Abstract Doc Link 11566050 Disease Relevance 0.17 Pain Relevance 0.17
The AChE mAb-induced alteration in sympathetic activity did not affect the suppressive effects of acute morphine treatment on the mitogen-stimulated proliferative response of splenic T and B cells and blood T cells, splenic NK cell activity, and the production of IFN-gamma and IL-2 by stimulated splenocytes.
Neg (not) Regulation (effects) of Gene_expression (production) of IFN-gamma in NK cell associated with morphine
4) Confidence 0.31 Published 1997 Journal Brain Behav. Immun. Section Abstract Doc Link 9417803 Disease Relevance 0 Pain Relevance 0.31
The role of gonadal hormones and persistent pain (formalin test) in the regulation of interferon-gamma (IFN-gamma) production in splenocytes was investigated in male and female rats.
Regulation (regulation) of Gene_expression (production) of IFN-gamma in gonadal associated with pain and lasting pain
5) Confidence 0.27 Published 2001 Journal Brain Behav. Immun. Section Abstract Doc Link 11566050 Disease Relevance 0.17 Pain Relevance 0.17
In contrast, proliferation of splenic T and B cells and interferon-gamma production are not altered within 30 min; maximal suppression occurs at 1 h, and recovery begins within 2 h.
Neg (not) Regulation (altered) of Gene_expression (production) of interferon-gamma in B cells
6) Confidence 0.27 Published 1997 Journal Anesth. Analg. Section Abstract Doc Link 9296419 Disease Relevance 0 Pain Relevance 1.42
Morphine's suppressive effects on the proliferative response of splenic T cells to PHA and the production of interferon-gamma by stimulated splenocytes also involve sympathetic activity, but not sympathoadrenal activity.
Regulation (effects) of Gene_expression (production) of interferon-gamma in sympathetic associated with morphine
7) Confidence 0.25 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8627540 Disease Relevance 0 Pain Relevance 0.76
Chlorisondamine, but not adrenalectomy, antagonizes morphine's suppressive effects on phytohemagglutinin (PHA)-stimulated proliferation of splenic lymphocytes and interferon-gamma production by stimulated splenocytes.
Regulation (effects) of Gene_expression (production) of interferon-gamma in lymphocytes associated with morphine
8) Confidence 0.25 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8627540 Disease Relevance 0 Pain Relevance 0.68
The expression of interleukin (IL)-1alpha, IL-1beta, IL-6, macrophage inflammatory protein-2, interferon-gamma, and tumor necrosis factor-alpha was measured by semiquantitative reverse-transcription polymerase chain reaction.
Regulation (measured) of Gene_expression (expression) of interferon-gamma in macrophage
9) Confidence 0.19 Published 1999 Journal Anesthesiology Section Body Doc Link 10598627 Disease Relevance 0 Pain Relevance 0
Effects of cortisol on in vitro interferon-gamma production, acute-phase proteins, growth, and feed intake in a calf castration model.
Regulation (Effects) of Gene_expression (production) of interferon-gamma
10) Confidence 0.19 Published 1997 Journal J. Anim. Sci. Section Title Doc Link 9110218 Disease Relevance 0.19 Pain Relevance 0.14
Treatment with AChE mAb did not alter the mitogen-stimulated proliferation of splenic B cells or blood T cells, splenic natural killer (NK) cell activity, or the production of interferon-gamma (IFN-gamma) by stimulated splenocytes, indicating that these immune measures are relatively insensitive to the AChE mAb-induced alteration in sympathetic activity.
Neg (not) Regulation (alter) of Gene_expression (production) of interferon-gamma in sympathetic
11) Confidence 0.19 Published 1997 Journal Brain Behav. Immun. Section Abstract Doc Link 9417803 Disease Relevance 0 Pain Relevance 0.38
Finally, SNC 80 did not affect interferon-gamma- or lipopolysaccharide (LPS)-induced splenic nitric oxide, and LPS-induced tumor necrosis factor-alpha production by splenic macrophages.
Neg (not) Regulation (affect) of Gene_expression (production) of interferon-gamma in splenic macrophages associated with necrosis and cancer
12) Confidence 0.15 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9694952 Disease Relevance 0.29 Pain Relevance 0.26
Effects of lidocaine on proliferative response, mRNA expression, and protein production of IL-5 and IFN-gamma by PBMCs were investigated after stimulation with Dermatophagoides farinae, purified protein derivative, and phorbol 12-myristate 13-acetate plus calcium ionophore.
Spec (investigated) Regulation (Effects) of Gene_expression (production) of IFN-gamma
13) Confidence 0.03 Published 2002 Journal J. Allergy Clin. Immunol. Section Body Doc Link 11897996 Disease Relevance 0.08 Pain Relevance 0

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