INT62270

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Context Info
Confidence 0.47
First Reported 1996
Last Reported 2010
Negated 2
Speculated 2
Reported most in Abstract
Documents 30
Total Number 32
Disease Relevance 18.73
Pain Relevance 5.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Cdkn1a) nucleus (Cdkn1a) cell cycle (Cdkn1a)
kinase activity (Cdkn1a) cytoplasm (Cdkn1a)
Anatomy Link Frequency
HT29 5
MCF-7 4
ducts 4
NIH-3T3 2
A549 1
Cdkn1a (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 11 99.98 Very High Very High Very High
lidocaine 9 99.18 Very High Very High Very High
Chronic pancreatitis 48 98.48 Very High Very High Very High
fluoxetine 22 97.44 Very High Very High Very High
local anesthetic 3 95.00 High High
cINOD 5 70.12 Quite High
Glutamate 2 69.80 Quite High
antidepressant 3 61.64 Quite High
Dismenorea 5 50.00 Quite Low
Inflammation 7 49.84 Quite Low
Disease Link Frequency Relevance Heat
Apoptosis 94 99.74 Very High Very High Very High
Adenocarcinoma 63 99.60 Very High Very High Very High
Reprotox - General 1 10 99.58 Very High Very High Very High
Myeloid Leukemia 9 98.62 Very High Very High Very High
Pancreatitis 48 98.48 Very High Very High Very High
Carcinoma 25 98.20 Very High Very High Very High
Lymphatic System Cancer 51 98.14 Very High Very High Very High
Colon Cancer 11 98.00 Very High Very High Very High
Cancer 223 97.44 Very High Very High Very High
Pancreatic Cancer 24 97.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Lidocaine inhibits NIH-3T3 cell multiplication by increasing the expression of cyclin-dependent kinase inhibitor 1A (p21).
Positive_regulation (increasing) of Gene_expression (expression) of p21 in NIH-3T3 associated with lidocaine
1) Confidence 0.47 Published 2008 Journal Anesth. Analg. Section Title Doc Link 18931217 Disease Relevance 0.09 Pain Relevance 0.38
On day 1.5, lidocaine upregulated expression of cyclin-D1 and cyclin-dependent kinase inhibitor 1A [p21].
Positive_regulation (upregulated) of Gene_expression (expression) of p21
2) Confidence 0.47 Published 2008 Journal Anesth. Analg. Section Body Doc Link 18931217 Disease Relevance 0 Pain Relevance 0
On day 2.5, lidocaine increased the levels of p21 protein.
Positive_regulation (increased) of Gene_expression (levels) of p21
3) Confidence 0.44 Published 2008 Journal Anesth. Analg. Section Body Doc Link 18931217 Disease Relevance 0 Pain Relevance 0
Treatment with GSH after AAP induced expression of cyclin D1, p21, and PCNA (12-48 h).
Positive_regulation (induced) of Gene_expression (expression) of p21 associated with paracetamol
4) Confidence 0.40 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12954812 Disease Relevance 0.34 Pain Relevance 0.63
CDKN1A reporter expression is enhanced after transfection with PBX1 and HOXA10, especially when MEIS1 was co-transfected (Bromleigh and Freedman, 2000).
Positive_regulation (enhanced) of Gene_expression (expression) of CDKN1A
5) Confidence 0.39 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0.25 Pain Relevance 0
Pancreatic-derived factor (PANDER)-induced down-regulation of CDKN1A (cyclin-dependent kinase inhibitor 1A (P21)) expression coupled with induced CASP3-activation may serve a central role in islet cell death [132].
Positive_regulation (induced) of Gene_expression (expression) of CDKN1A associated with death
6) Confidence 0.27 Published 2008 Journal Current Genomics Section Body Doc Link PMC2685644 Disease Relevance 0.69 Pain Relevance 0.03
is activated by gossypol in prostate cancer cells, and gossypol upregulates p21 expression and downregulates cyclin D1 and Rb expression in colon cancer cells [8,9].
Positive_regulation (upregulates) of Gene_expression (expression) of p21 in colon associated with colon cancer and reprotox - general 1
7) Confidence 0.23 Published 2009 Journal J Transl Med Section Body Doc Link PMC2742515 Disease Relevance 1.06 Pain Relevance 0
Moreover, expression of p21 protein was upregulated as early as 24 h and gradually returned to low level at 72 h since most of the CNE-2 cells were dead at this time (Fig. 3B); unlike p21, expression of both cyclin D1 and cyclin E were downregulated following the degradation of c-Myc.
Positive_regulation (upregulated) of Gene_expression (expression) of p21
8) Confidence 0.23 Published 2009 Journal J Transl Med Section Body Doc Link PMC2742515 Disease Relevance 0.32 Pain Relevance 0
Our study demonstrated the overexpression of p21WAF1/CIP1 as an early event in the development of pancreatic intraepithelial neoplasia in the group of chronic pancreatitis and invasive adenocarcinoma as well.
Positive_regulation (overexpression) of Gene_expression (overexpression) of p21WAF1/CIP1 associated with adenocarcinoma, cancer and chronic pancreatitis
9) Confidence 0.20 Published 2003 Journal Neoplasma Section Abstract Doc Link 14628083 Disease Relevance 0.98 Pain Relevance 0.25
Overexpression of p21WAF1/CIP1 increased progressively from normal ducts through the spectrum of PanIN lesions to invasive carcinomas.
Positive_regulation (increased) of Gene_expression (Overexpression) of p21WAF1/CIP1 in ducts associated with carcinoma
10) Confidence 0.20 Published 2003 Journal Neoplasma Section Abstract Doc Link 14628083 Disease Relevance 1.10 Pain Relevance 0.25
The possible role of activating K-ras mutations in an induction of p21WAF1/CIP1 expression was not confirmed in this study.
Positive_regulation (induction) of Gene_expression (expression) of p21WAF1/CIP1
11) Confidence 0.20 Published 2003 Journal Neoplasma Section Abstract Doc Link 14628083 Disease Relevance 0.89 Pain Relevance 0.22
Since activating K-ras mutations are described in more than 80% of pancreatic cancers and are known to increase intracellular levels of p21WAF1/CIP1 in experimental models, the possible role of activating K-ras mutations in an induction of the p21WAF1/CIP1 expression was investigated in our study.
Positive_regulation (induction) of Gene_expression (expression) of p21WAF1/CIP1 associated with pancreatic cancer
12) Confidence 0.20 Published 2003 Journal Neoplasma Section Abstract Doc Link 14628083 Disease Relevance 0.71 Pain Relevance 0.22
Overexpression of p21WAF1/CIP1 was recently described as an early event in the development of pancreatic intraepithelial neoplasia.
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of p21WAF1/CIP1 associated with cancer
13) Confidence 0.20 Published 2003 Journal Neoplasma Section Abstract Doc Link 14628083 Disease Relevance 0.51 Pain Relevance 0.14
Overexpression of p21WAF1/CIP1 increased progressively from normal ducts through the spectrum of PanIN lesions to invasive carcinomas.
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of p21WAF1/CIP1 in ducts associated with carcinoma
14) Confidence 0.20 Published 2003 Journal Neoplasma Section Abstract Doc Link 14628083 Disease Relevance 1.10 Pain Relevance 0.25
As shown in fig. 4A, all these three oligonucleotides significantly suppressed the expression of c-Myc protein; the reduction in c-Myc expression led to upregulation of p21 expression and downregulation of cyclin D expression.
Positive_regulation (upregulation) of Gene_expression (expression) of p21
15) Confidence 0.17 Published 2009 Journal J Transl Med Section Body Doc Link PMC2742515 Disease Relevance 0.48 Pain Relevance 0
Our study demonstrated the overexpression of p21WAF1/CIP1 as an early event in the development of pancreatic intraepithelial neoplasia in the group of chronic pancreatitis and invasive adenocarcinoma as well.
Positive_regulation (overexpression) of Gene_expression (overexpression) of p21WAF1/CIP1 associated with adenocarcinoma, cancer and chronic pancreatitis
16) Confidence 0.14 Published 2003 Journal Neoplasma Section Abstract Doc Link 14628083 Disease Relevance 0.98 Pain Relevance 0.25
Overexpression of p21WAF1/CIP1 was recently described as an early event in the development of pancreatic intraepithelial neoplasia.
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of p21WAF1/CIP1 associated with cancer
17) Confidence 0.14 Published 2003 Journal Neoplasma Section Abstract Doc Link 14628083 Disease Relevance 0.51 Pain Relevance 0.14
Since activating K-ras mutations are described in more than 80% of pancreatic cancers and are known to increase intracellular levels of p21WAF1/CIP1 in experimental models, the possible role of activating K-ras mutations in an induction of the p21WAF1/CIP1 expression was investigated in our study.
Positive_regulation (induction) of Gene_expression (expression) of p21WAF1/CIP1 associated with pancreatic cancer
18) Confidence 0.14 Published 2003 Journal Neoplasma Section Abstract Doc Link 14628083 Disease Relevance 0.71 Pain Relevance 0.22
The possible role of activating K-ras mutations in an induction of p21WAF1/CIP1 expression was not confirmed in this study.
Positive_regulation (induction) of Gene_expression (expression) of p21WAF1/CIP1
19) Confidence 0.14 Published 2003 Journal Neoplasma Section Abstract Doc Link 14628083 Disease Relevance 0.89 Pain Relevance 0.22
Our results confirmed also the possible p53 independent p21WAF1/CIP1 expression in some PanIN2, PanIN3 lesions and invasive carcinomas.
Neg (independent) Spec (possible) Positive_regulation (independent) of Gene_expression (expression) of p21WAF1/CIP1 associated with carcinoma
20) Confidence 0.14 Published 2003 Journal Neoplasma Section Abstract Doc Link 14628083 Disease Relevance 1.18 Pain Relevance 0.30

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