INT6231

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Context Info
Confidence 0.26
First Reported 1992
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 2.56
Pain Relevance 1.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
spinal 1
spinal cord 1
lung 1
Col6a6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 14 100.00 Very High Very High Very High
Sciatic nerve 3 99.80 Very High Very High Very High
fibrosis 1 99.14 Very High Very High Very High
Spontaneous pain 2 99.00 Very High Very High Very High
Eae 8 97.88 Very High Very High Very High
Thermal hyperalgesia 4 96.48 Very High Very High Very High
Pain 5 92.12 High High
allodynia 1 89.04 High High
Dorsal horn 2 79.96 Quite High
qutenza 3 75.00 Quite High
Disease Link Frequency Relevance Heat
Fibroma 1 99.70 Very High Very High Very High
Pulmonary Fibrosis 1 99.14 Very High Very High Very High
Pain 4 99.00 Very High Very High Very High
Fibrosis 1 98.40 Very High Very High Very High
Injury 13 97.88 Very High Very High Very High
Hyperalgesia 4 96.48 Very High Very High Very High
Experimental Autoimmune Neuritis 6 95.52 Very High Very High Very High
Neuropathic Pain 6 95.52 Very High Very High Very High
Nociception 2 91.56 High High
Diabetic Nephropathy 2 75.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Sciatic nerve ligation produced a significant increase in spinal cord metabolic activity in four sampling regions (laminae I-IV, V-VI, VII and VIII-IX) of lumbar segments compared to sham-operated rats.
Gene_expression (produced) of V-VI in spinal cord associated with sciatic nerve and spinal cord
1) Confidence 0.26 Published 1992 Journal Pain Section Abstract Doc Link 1325049 Disease Relevance 0.51 Pain Relevance 0.69
There were no significant changes of the expression of alpha6 and laminin both in the acute phase and recovery phase of EANs by immunohistochemistry (alpha6 P=0.0751;laminin P=0.2047).
Gene_expression (expression) of alpha6
2) Confidence 0.08 Published 2003 Journal Beijing Da Xue Xue Bao Section Body Doc Link 14710253 Disease Relevance 0.08 Pain Relevance 0
The expressions of integrins alpha6 and beta 4 and their receptor laminin, both in the acute phase and recovery phase of EANs, were analyzed by in situ hybridization and immunohistochemistry.
Spec (analyzed) Gene_expression (expressions) of alpha6
3) Confidence 0.07 Published 2003 Journal Beijing Da Xue Xue Bao Section Body Doc Link 14710253 Disease Relevance 0.10 Pain Relevance 0
The expression changes of alpha6 and beta4 correlate with the injury and repair of myelin during EAN.


Gene_expression (expression) of alpha6
4) Confidence 0.05 Published 2003 Journal Beijing Da Xue Xue Bao Section Body Doc Link 14710253 Disease Relevance 0.06 Pain Relevance 0
In similar pathological conditions with fibrotic transformation such as lung fibrosis or superficial fibromatoses, an increased expression of collagen type VI has been reported.
Gene_expression (expression) of collagen type VI in lung associated with fibroma, fibrosis and pulmonary fibrosis
5) Confidence 0.03 Published 1999 Journal Arch Orthop Trauma Surg Section Abstract Doc Link 10447630 Disease Relevance 0.54 Pain Relevance 0.14
These findings demonstrate that the increased expression of NR1 and pNR1 in spinal laminae I-II and V-VI is dependent on activation of CSPAs, which ultimately contribute to the development of thermal hyperalgesia in neuropathic rats.
Gene_expression (expression) of V-VI in spinal associated with thermal hyperalgesia and neuropathic pain
6) Confidence 0.01 Published 2008 Journal Eur J Pain Section Abstract Doc Link 17933570 Disease Relevance 1.28 Pain Relevance 0.95

General Comments

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