INT625

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Context Info
Confidence 0.80
First Reported 1976
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 35
Total Number 36
Disease Relevance 11.33
Pain Relevance 3.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (PGC) extracellular space (PGC) extracellular region (PGC)
nucleolus (PGC) nucleus (PGC)
Anatomy Link Frequency
peptic cells 2
stomach 2
AGS 2
pituitary 1
lumen 1
PGC (Homo sapiens)
Pain Link Frequency Relevance Heat
Serotonin 2 100.00 Very High Very High Very High
peptic ulcer disease 29 98.72 Very High Very High Very High
cINOD 43 96.88 Very High Very High Very High
Potency 2 96.28 Very High Very High Very High
Somatostatin 11 95.78 Very High Very High Very High
adenocard 4 95.68 Very High Very High Very High
Neurotransmitter 1 95.32 Very High Very High Very High
antagonist 3 91.92 High High
headache 5 89.20 High High
antidepressant 1 88.24 High High
Disease Link Frequency Relevance Heat
Alagille Syndrome 8 99.76 Very High Very High Very High
Gastritis 15 99.32 Very High Very High Very High
Adenocarcinoma 8 99.28 Very High Very High Very High
Injury 33 98.80 Very High Very High Very High
Ulcers 61 98.72 Very High Very High Very High
Duodenal Ulcer 8 98.64 Very High Very High Very High
Disease 42 98.20 Very High Very High Very High
Hypoglycemia 86 96.96 Very High Very High Very High
Peptic Ulcer 15 96.40 Very High Very High Very High
INFLAMMATION 15 95.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This will facilitate the study of pepsin secretion, particularly in patients with peptic ulcer disease.
Localization (secretion) of pepsin associated with peptic ulcer disease and disease
1) Confidence 0.80 Published 1989 Journal J. Chromatogr. Section Abstract Doc Link 2506210 Disease Relevance 0.20 Pain Relevance 0.10
We investigated cellular signaling and pepsinogen secretion in the human gastric adenocarcinoma cell line AGS which was pretreated with the purified vacuolating cytotoxin from Helicobacter pylori.
Spec (investigated) Localization (secretion) of pepsinogen in AGS associated with adenocarcinoma, alagille syndrome and gastritis
2) Confidence 0.79 Published 1996 Journal FEBS Lett. Section Abstract Doc Link 8980135 Disease Relevance 0.51 Pain Relevance 0.04
Vacuolating toxin from Helicobacter pylori activates cellular signaling and pepsinogen secretion in human gastric adenocarcinoma cells.
Localization (secretion) of pepsinogen associated with adenocarcinoma and gastritis
3) Confidence 0.79 Published 1996 Journal FEBS Lett. Section Title Doc Link 8980135 Disease Relevance 0.56 Pain Relevance 0.11
Moreover, pepsinogen secretion from AGS cells was stimulated with increasing concentrations of cytotoxin.
Localization (secretion) of pepsinogen in AGS associated with alagille syndrome
4) Confidence 0.79 Published 1996 Journal FEBS Lett. Section Abstract Doc Link 8980135 Disease Relevance 0.51 Pain Relevance 0.12
Increase of pepsinogen secretion was dependent on extracellular calcium because potentiation was abolished by calcium depletion of the medium.
Localization (secretion) of pepsinogen
5) Confidence 0.78 Published 1996 Journal Rev Esp Enferm Dig Section Abstract Doc Link 9004795 Disease Relevance 0.08 Pain Relevance 0.08
[Effect of indomethacin on the secretion of pepsinogen in isolated human cells in vitro].
Localization (secretion) of pepsinogen
6) Confidence 0.78 Published 1996 Journal Rev Esp Enferm Dig Section Title Doc Link 9004795 Disease Relevance 0.06 Pain Relevance 0.06
Low concentrations of indomethacin (10(-8)-10(-10) M) stimulated basal pepsinogen secretion.
Localization (secretion) of pepsinogen
7) Confidence 0.78 Published 1996 Journal Rev Esp Enferm Dig Section Abstract Doc Link 9004795 Disease Relevance 0.05 Pain Relevance 0.06
We conclude that indomethacin potentiates basal and secretagogue-stimulated pepsinogen secretion by dispersed human peptic cells and this might be an additional mechanism of NSAID-induced gastric injury.
Localization (secretion) of pepsinogen in peptic cells associated with injury and cinod
8) Confidence 0.78 Published 1996 Journal Rev Esp Enferm Dig Section Abstract Doc Link 9004795 Disease Relevance 0.10 Pain Relevance 0.10
Secretion of total pepsin and pepsin 1 in healthy volunteers in response to pentagastrin and to insulin-induced hypoglycaemia.
Localization (Secretion) of pepsin associated with hypoglycemia
9) Confidence 0.74 Published 2007 Journal Scand. J. Gastroenterol. Section Title Doc Link 17454875 Disease Relevance 0.28 Pain Relevance 0.09
CONCLUSIONS: Both pentagastrin and hypoglycaemia caused similar maximal secretion rates of pepsin 1, but hypoglycaemia caused greater secretion rates of total pepsin.
Localization (secretion) of pepsin
10) Confidence 0.74 Published 2007 Journal Scand. J. Gastroenterol. Section Body Doc Link 17454875 Disease Relevance 0 Pain Relevance 0
The maximum concentrations and secretion rates of pepsin 1 occurred at different times from those of total pepsin and there is a threshold of total pepsin secretion below which pepsin 1 was not released.


Localization (secretion) of pepsin
11) Confidence 0.74 Published 2007 Journal Scand. J. Gastroenterol. Section Body Doc Link 17454875 Disease Relevance 0 Pain Relevance 0
The maximum concentrations and secretion rates of pepsin 1 occurred at different times from those of total pepsin and there is a threshold of total pepsin secretion below which pepsin 1 was not released.


Localization (secretion) of pepsin
12) Confidence 0.74 Published 2007 Journal Scand. J. Gastroenterol. Section Body Doc Link 17454875 Disease Relevance 0 Pain Relevance 0
Secretion of total pepsin and pepsin 1 in healthy volunteers in response to pentagastrin and to insulin-induced hypoglycaemia.
Localization (Secretion) of pepsin associated with hypoglycemia
13) Confidence 0.74 Published 2007 Journal Scand. J. Gastroenterol. Section Title Doc Link 17454875 Disease Relevance 0.28 Pain Relevance 0.09
The maximum concentrations and secretion rates of pepsin 1 occurred at different times from those of total pepsin and there is a threshold of total pepsin secretion below which pepsin 1 was not released.


Localization (secretion) of pepsin
14) Confidence 0.74 Published 2007 Journal Scand. J. Gastroenterol. Section Body Doc Link 17454875 Disease Relevance 0 Pain Relevance 0
Following intravenous insulin administration to 11 subjects, the mean concentration and secretion rates of pepsin 1 rose to 33 microg/ml and 127 microg/min at 60 min: the proportion of pepsin 1 to total pepsin was 0.8% in basal secretions and 3.1% in the 50 to 60-min samples.
Localization (secretion) of pepsin
15) Confidence 0.74 Published 2007 Journal Scand. J. Gastroenterol. Section Body Doc Link 17454875 Disease Relevance 0 Pain Relevance 0
There is, however, a dynamic balance between digestion by pepsin of the mucus layer at its luminal aspect and secretion of new mucus by the epithelium.
Localization (secretion) of pepsin in epithelium
16) Confidence 0.70 Published 1988 Journal J. Clin. Gastroenterol. Section Abstract Doc Link 3053885 Disease Relevance 0.19 Pain Relevance 0.14
We conclude that besides the H. pylori cytotoxin-induced cellular vacuoles, cytotoxin-stimulated signaling mediators and pepsinogen release are important factors involved in the etiology of chronic active gastritis and peptic ulcer disease.
Localization (release) of pepsinogen associated with peptic ulcer disease, disease and gastritis
17) Confidence 0.69 Published 1996 Journal FEBS Lett. Section Abstract Doc Link 8980135 Disease Relevance 0.77 Pain Relevance 0.14
Following intravenous insulin administration to 11 subjects, the mean concentration and secretion rates of pepsin 1 rose to 33 microg/ml and 127 microg/min at 60 min: the proportion of pepsin 1 to total pepsin was 0.8% in basal secretions and 3.1% in the 50 to 60-min samples.
Localization (secretions) of pepsin
18) Confidence 0.69 Published 2007 Journal Scand. J. Gastroenterol. Section Body Doc Link 17454875 Disease Relevance 0 Pain Relevance 0
Following intravenous insulin administration to 11 subjects, the mean concentration and secretion rates of pepsin 1 rose to 33 microg/ml and 127 microg/min at 60 min: the proportion of pepsin 1 to total pepsin was 0.8% in basal secretions and 3.1% in the 50 to 60-min samples.
Localization (secretions) of pepsin
19) Confidence 0.69 Published 2007 Journal Scand. J. Gastroenterol. Section Body Doc Link 17454875 Disease Relevance 0 Pain Relevance 0
Higher doses of indomethacin (10(-5)-10(-6) M) potentiated histamine (10(-4) M) and db-cAMP (10(-4) M)-stimulated pepsinogen secretion without affecting acetylcholine (10(-6) M) and CCK-8-stimulated pepsinogen secretion or cell vitality.
Localization (secretion) of pepsinogen
20) Confidence 0.68 Published 1996 Journal Rev Esp Enferm Dig Section Abstract Doc Link 9004795 Disease Relevance 0.07 Pain Relevance 0.07

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