INT62692

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Context Info
Confidence 0.73
First Reported 1995
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 0.82
Pain Relevance 1.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Nanog) nucleoplasm (Nanog) nucleolus (Nanog)
nucleus (Nanog) embryo development (Nanog) DNA binding (Nanog)
Anatomy Link Frequency
dorsal horn 1
Nanog (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 16 100.00 Very High Very High Very High
Calcitonin gene-related peptide 11 100.00 Very High Very High Very High
Neuropeptide 9 100.00 Very High Very High Very High
gABA 44 99.52 Very High Very High Very High
spinal dorsal horn 6 99.04 Very High Very High Very High
substance P 24 96.28 Very High Very High Very High
GABAergic 9 75.00 Quite High
cytokine 2 67.88 Quite High
Inflammation 8 67.52 Quite High
Neurotransmitter 31 52.08 Quite High
Disease Link Frequency Relevance Heat
Bullous Skin Disease 75 98.08 Very High Very High Very High
Generalized Anxiety Disorder 20 96.72 Very High Very High Very High
Targeted Disruption 3 95.04 Very High Very High Very High
Hepatotoxicity 2 89.28 High High
Recurrence 6 84.96 Quite High
Neuroblastoma 2 76.40 Quite High
INFLAMMATION 8 67.52 Quite High
Disease 35 6.24 Low Low
Blister 8 5.00 Very Low Very Low Very Low
Adhesions 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We next determined whether induced MSCs synthesize and/or release other neuropeptides, specifically VIP, CGRP and Leu-Enk (Figs. 1B-1D).
Localization (release) of Enk associated with neuropeptide and calcitonin gene-related peptide
1) Confidence 0.73 Published 2008 Journal Biological Procedures Online Section Body Doc Link PMC2683550 Disease Relevance 0.07 Pain Relevance 0.58
Furthermore, release studies showed that the [Met]-Enk was secreted from these cells with high K+ stimulation.
Localization (secreted) of Enk
2) Confidence 0.72 Published 1995 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 8674823 Disease Relevance 0.15 Pain Relevance 0.62
In this study, we examined the colocalization of enkephalin (ENK) mRNA with GABA in the spinal dorsal horn using the glutamic acid decarboxylase (GAD)(67)-green fluorescence protein (GFP) knock-in mouse.
Spec (examined) Localization (colocalization) of ENK in dorsal horn associated with targeted disruption, gaba, generalized anxiety disorder, spinal dorsal horn and enkephalin
3) Confidence 0.68 Published 2008 Journal Anatomical record (Hoboken, N.J. : 2007) Section Abstract Doc Link 18780300 Disease Relevance 0.27 Pain Relevance 0.66
Its use was later reported (Enk and Knop 1999) in 12 patients who failed combination therapy with prednisone and azathioprine.
Localization (reported) of Enk
4) Confidence 0.34 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1936286 Disease Relevance 0.34 Pain Relevance 0

General Comments

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