INT63025

Context Info Confidence 0.75 First Reported 1995 Last Reported 2007 Negated 0 Speculated 1 Reported most in Abstract Documents 10 Total Number 11 Disease Relevance 3.79 Pain Relevance 3.30

nucleus (BHLHE22)

Anatomy Link Frequency sensory neurons 2 nerves 1 arms 1 platelet 1 ECM 1 BHLHE22 (Homo sapiens) BHLHE22 - C825T (1)

Pain Link Frequency Relevance Heat sodium channel 14 100.00 metalloproteinase 2 98.64 addiction 2 97.76 nav1.8 6 97.72 aspirin 1 97.28 Chronic pancreatitis 9 97.08 Pain 3 95.76 fibrosis 1 95.04 IPN 4 93.00 Neurotransmitter 1 91.20

Disease Link Frequency Relevance Heat Adhesions 3 100.00 Obesity 3 99.84 Cancer 1 99.48 Injury 6 99.44 Hypertension 6 98.60 Adenocarcinoma 7 98.48 Pancreatitis 10 98.24 Acute Coronary Syndrome 1 96.48 Pain 3 95.76 Fibrosis 1 95.04

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Expression of nine alpha-subunits (alpha 2-alpha 6, alpha V, alpha L, alpha M, and alpha X), four beta-subunits (beta 1, beta 3-beta 5), and four ECM molecules (type IV collagen, laminin, fibronectin, and vitronectin) was investigated immunohistochemically.

Spec (investigated) Gene_expression (Expression) of beta 3 in ECM

1) Confidence 0.75 Published 1995 Journal Int. J. Pancreatol. Section Abstract Doc Link 8708394 Disease Relevance 0.96 Pain Relevance 0.50

Atypical beta-adrenoceptors or beta3-adrenoceptors, which are present on adipocytes, have been demonstrated pharmacologically.

Gene_expression (present) of beta3 in adipocytes associated with obesity

2) Confidence 0.65 Published 1998 Journal Eur. J. Clin. Pharmacol. Section Abstract Doc Link 9551698 Disease Relevance 0.43 Pain Relevance 0.23

The discovery of the platelet integrin receptor alpha(IIb)beta3, also known as the platelet glycoprotein (GP) IIb-IIIa receptor, is a breakthrough in antiplatelet therapy.

Gene_expression (discovery) of beta3 in platelet

3) Confidence 0.65 Published 1998 Journal Pharmacotherapy Section Abstract Doc Link 9692642 Disease Relevance 0.26 Pain Relevance 0.18

[C825T polymorphism of the GNB3 gene codifying the G-protein beta3-subunit and cardiovascular risk].

Gene_expression (codifying) of beta3 (C825T)

4) Confidence 0.65 Published 2004 Journal Ann. Ital. Med. Int. Section Title Doc Link 15678704 Disease Relevance 0.80 Pain Relevance 0.06

Expression of the sodium channel beta3 subunit in injured human sensory neurons.

Gene_expression (Expression) of beta3 in sensory neurons associated with sodium channel

5) Confidence 0.55 Published 2004 Journal Neuroreport Section Title Doc Link 15232296 Disease Relevance 0.26 Pain Relevance 0.46

Coexpression of beta1 or beta3 did not affect inactivation time course or the voltage dependence of activation, but shifted the inactivation curve approximately 10 mV negative, and slowed the repriming rate ca. three-fold. beta2 did not affect channel properties, either by itself or in combination with beta1 or beta3.

Gene_expression (Coexpression) of beta3 associated with addiction

6) Confidence 0.51 Published 2002 Journal Neuroscience Section Abstract Doc Link 12220575 Disease Relevance 0.07 Pain Relevance 0.31

Excitable cells express multiple alpha subtypes, designated Na(v)1.1-Na(v)1.9, and three beta subunits, designated beta1, beta2 and beta3.

Gene_expression (express) of beta3

7) Confidence 0.51 Published 2002 Journal Neuroscience Section Abstract Doc Link 12220575 Disease Relevance 0 Pain Relevance 0.25

Unlike beta1- and beta2, beta3-immunoreactivity did not decrease after avulsion injury, and the beta3:neurofilament ratio was significantly increased in proximal injured human nerves. beta3-subunit expression may thus be regulated differently from beta1, beta2 and Nav1.8.

Gene_expression (expression) of beta3 in nerves associated with injury and nav1.8

8) Confidence 0.48 Published 2004 Journal Neuroreport Section Abstract Doc Link 15232296 Disease Relevance 0.26 Pain Relevance 0.51

We have now detected, by immunohistochemistry, beta3-subunits in 82% of small/medium and 67% of large diameter sensory neurons in intact human dorsal root ganglia: 54% of beta3 small/medium neurons were NGF receptor trkA negative.

Gene_expression (detected) of beta3 in sensory neurons

9) Confidence 0.42 Published 2004 Journal Neuroreport Section Abstract Doc Link 15232296 Disease Relevance 0.27 Pain Relevance 0.41

To investigate beta1 and beta3 containing integrin-mediated adhesion and subsequent MMP-2/-9 protein and gene expression in human blood-derived monocytes, biofunctional peptides immobilized onto flexible polyethylene glycol (PEG) arms were grafted onto a gelatin-based interpenetrating network (IPN).

Gene_expression (expression) of beta3 in arms associated with ipn and adhesions

10) Confidence 0.16 Published 2007 Journal Biomaterials Section Abstract Doc Link 16979234 Disease Relevance 0.17 Pain Relevance 0.25

Expression of transforming growth factor beta1, beta2, and beta3 in chronic, cancer-associated, obstructive pancreatitis.

Gene_expression (Expression) of beta3 associated with cancer and pancreatitis

11) Confidence 0.13 Published 2006 Journal Arch. Pathol. Lab. Med. Section Title Doc Link 16519564 Disease Relevance 0.29 Pain Relevance 0.14

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