INT63348

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Context Info
Confidence 0.40
First Reported 1996
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 14
Total Number 15
Disease Relevance 16.05
Pain Relevance 0.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (PECAM1) extracellular space (PECAM1) cell adhesion (PECAM1)
plasma membrane (PECAM1)
Anatomy Link Frequency
leukocytes 2
granulocytes 1
neuronal 1
epithelium 1
endothelium 1
PECAM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 53 97.72 Very High Very High Very High
Inflammatory mediators 7 96.04 Very High Very High Very High
Inflammation 214 90.40 High High
anesthesia 1 89.52 High High
cINOD 2 86.40 High High
Bile 9 55.52 Quite High
tolerance 6 53.44 Quite High
abdominal pain 5 52.00 Quite High
Opioid 1 50.60 Quite High
Chronic pancreatitis 4 49.52 Quite Low
Disease Link Frequency Relevance Heat
Adhesions 637 100.00 Very High Very High Very High
Nicotine Addiction 1098 99.82 Very High Very High Very High
Pre-eclampsia 46 97.80 Very High Very High Very High
Cancer 112 97.76 Very High Very High Very High
Chronic Obstructive Pulmonary Disease 132 96.80 Very High Very High Very High
Body Weight 3 96.72 Very High Very High Very High
INFLAMMATION 258 95.64 Very High Very High Very High
Disease 165 94.56 High High
Malignant Neoplastic Disease 25 93.84 High High
Periodontal Disease 66 93.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These observations point to a smoking-induced dysregulation of adhesion molecule networks in the pulmonary environment.
Regulation (dysregulation) of adhesion molecule associated with nicotine addiction and adhesions
1) Confidence 0.40 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2669563 Disease Relevance 1.53 Pain Relevance 0.07
These observations point to a smoking-induced dysregulation of adhesion molecule networks in the pulmonary environment.
Regulation (dysregulation) of adhesion molecule associated with nicotine addiction and adhesions
2) Confidence 0.40 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2671531 Disease Relevance 1.53 Pain Relevance 0.07
Schaberg et al. [93] also noted a strong correlation between cumulative tobacco smoke exposure (pack-years) and the percentage of ICAM-1-positive pulmonary vessels, consistent with a role for smoking in increased pulmonary recruitment of leukocytes through the dysregulation of adhesion molecule networks.
Regulation (dysregulation) of adhesion molecule in leukocytes associated with nicotine addiction and adhesions
3) Confidence 0.40 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2671531 Disease Relevance 1.64 Pain Relevance 0.03
Schaberg et al. [93] also noted a strong correlation between cumulative tobacco smoke exposure (pack-years) and the percentage of ICAM-1-positive pulmonary vessels, consistent with a role for smoking in increased pulmonary recruitment of leukocytes through the dysregulation of adhesion molecule networks.
Regulation (dysregulation) of adhesion molecule in leukocytes associated with nicotine addiction and adhesions
4) Confidence 0.40 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2669563 Disease Relevance 1.64 Pain Relevance 0.03
However, such studies are at a preliminary stage, all tissues do not appear to respond equally, and the in vivo evidence for smoking-induced cell-associated adhesion molecule dysregulation has been obtained primarily with small numbers of patients.
Regulation (dysregulation) of adhesion molecule associated with nicotine addiction and adhesions
5) Confidence 0.18 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2671531 Disease Relevance 2.05 Pain Relevance 0.07
However, such studies are at a preliminary stage, all tissues do not appear to respond equally, and the in vivo evidence for smoking-induced cell-associated adhesion molecule dysregulation has been obtained primarily with small numbers of patients.
Regulation (dysregulation) of adhesion molecule associated with nicotine addiction and adhesions
6) Confidence 0.18 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2669563 Disease Relevance 2.05 Pain Relevance 0.07
In contrast, the expression of other adhesion molecules by neutrophils was unaffected (CD11a, CD31, CD44) or slightly increased (CD11b).
Neg (unaffected) Regulation (unaffected) of CD31 in neutrophils
7) Confidence 0.16 Published 1996 Journal J. Rheumatol. Section Body Doc Link 8730134 Disease Relevance 0.12 Pain Relevance 0
A recent direction for these therapeutics is targeting of the adhesion molecule family.
Regulation (targeting) of adhesion molecule associated with adhesions
8) Confidence 0.16 Published 2008 Journal Autoimmun Rev Section Abstract Doc Link 18486923 Disease Relevance 1.04 Pain Relevance 0.29
CD31 and CD34 immunoreactivity was not expressed by the cystic epithelium.
Regulation (immunoreactivity) of CD31 in epithelium
9) Confidence 0.12 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC3016302 Disease Relevance 1.23 Pain Relevance 0.08
In summary, we have determined the serum concentrations of soluble adhesion molecule VCAM-1, ICAM-1 and E-selectin in normal pregnancy and preeclampsia.
Spec (determined) Regulation (soluble) of adhesion molecule associated with pre-eclampsia and adhesions
10) Confidence 0.06 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816332 Disease Relevance 1.05 Pain Relevance 0.07
We did not observe any significant changes in the

adhesion molecules on granulocytes, but only a tendency to a decrease in CD62L levels 2 h after the start of CVVHD.

Neg (not) Regulation (changes) of adhesion in granulocytes associated with adhesions
11) Confidence 0.02 Published 1999 Journal Crit Care Section Body Doc Link PMC29032 Disease Relevance 0.90 Pain Relevance 0
The median channel value of the selectin

adhesion molecule CD62L decreased from 416 (25 and 75% quartiles 336 and 491) before the start of CVVHD to 360 (25 and 75% quartiles 340 and 463) and 389 (25 and 75% quartiles 330 and 491) 2 and 24 h later (not significant).

Regulation (value) of adhesion molecule associated with adhesions
12) Confidence 0.01 Published 1999 Journal Crit Care Section Body Doc Link PMC29032 Disease Relevance 0.19 Pain Relevance 0
The inactivation of T cells due to down-regulation of the adhesion molecule ligand (CD103+) and overexpression of immunosuppressive cytokines (TGF-?)
Regulation (regulation) of adhesion molecule in T cells associated with adhesions and cytokine
13) Confidence 0.01 Published 2007 Journal J Transl Med Section Body Doc Link PMC2217514 Disease Relevance 0.75 Pain Relevance 0.05
In vitro vascular reactivity and endothelium CD31-PECAM1 immunoreactivity were obtained at D5.


Regulation (immunoreactivity) of CD31-PECAM1 in endothelium
14) Confidence 0.00 Published 2006 Journal Crit Care Section Body Doc Link PMC1550919 Disease Relevance 0.10 Pain Relevance 0.09
These results indicate that OBCAM is a synaptic cell adhesion molecule concerning synaptogenesis and its surface localization is dynamically regulated in response to neuronal activity.
Regulation (regulated) of adhesion molecule in neuronal associated with adhesions
15) Confidence 0.00 Published 2007 Journal Brain Res. Section Abstract Doc Link 17658490 Disease Relevance 0.23 Pain Relevance 0.05

General Comments

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