INT63598

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Context Info
Confidence 0.70
First Reported 1996
Last Reported 1997
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 4
Disease Relevance 0.87
Pain Relevance 2.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Got1) biosynthetic process (Got1) cellular amino acid metabolic process (Got1)
lysosome (Got1) cytoplasm (Got1)
Anatomy Link Frequency
liver 3
Got1 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 18 99.82 Very High Very High Very High
Glutamate 8 96.64 Very High Very High Very High
Analgesic 5 89.68 High High
antagonist 1 75.00 Quite High
Disease Link Frequency Relevance Heat
Injury 4 90.60 High High
Hepatotoxicity 8 83.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The acetaminophen-induced release of both GOT and GPT from injured liver cells could be inhibited in a dose-dependent manner, when mice were injected additionally either with increasing amounts (from (25 mg/kg to 100 mg/kg i.p.) of the PARP-inhibitor nicotinamide, with increasing amounts (from 25 mg/kg to 100 mg/kg i.p.) of the antioxidant N-acetylcysteine, or with increasing amounts (from 50 mg/kg to 300 mg/kg i.p.) of the amino acid L-methionine. 4.
Localization (release) of GOT in liver associated with paracetamol
1) Confidence 0.70 Published 1997 Journal Gen. Pharmacol. Section Abstract Doc Link 9013204 Disease Relevance 0.25 Pain Relevance 0.51
While the PARP-activity remained essentially unchanged, the acetaminophen-induced release of both GOT and GPT from injured liver cells could be inhibited by 90-99%, when mice were injected additionally with the selective PARP-inhibitors nicotinic acid amide, benzamide, caffeine, theophyline, and thymidine, respectively.
Localization (release) of GOT in liver associated with paracetamol
2) Confidence 0.62 Published 1996 Journal Gen. Pharmacol. Section Abstract Doc Link 8742516 Disease Relevance 0.24 Pain Relevance 0.54
A combination of both nicotinamide and N-acetylcysteine (at the low dose of 12.5 mg/kg i.p. each) results in a complete protection from acetaminophen-induced release of GOT and GPT from injured liver cells. 5.
Localization (release) of GOT in liver associated with paracetamol
3) Confidence 0.61 Published 1997 Journal Gen. Pharmacol. Section Abstract Doc Link 9013204 Disease Relevance 0.20 Pain Relevance 0.54
A combination of both L-methionine and N-acetylcysteine or nicotinamide (at the low dose of 12.5 mg/kg IP each) resulted also in complete protection from acetaminophen-induced release of GOT and GPT.
Localization (release) of GOT associated with paracetamol
4) Confidence 0.61 Published 1997 Journal Gen. Pharmacol. Section Abstract Doc Link 9013204 Disease Relevance 0.18 Pain Relevance 0.51

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