INT6381
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
Results indicate that the decrease in ChAT activity depends upon the presence of the nociceptive input rather than its magnitude. | |||||||||||||||
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Decrease of hippocampal choline acetyltransferase activity induced by formalin pain. | |||||||||||||||
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Confirming earlier results, an almost total depletion of ChAT was obtained in the IPN following complete FR lesions at any survival day studied. | |||||||||||||||
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After a unilateral spinal cord lesion at C3, ChAT activity was reduced in the ipsilateral ventral horn at C6-7 caudal to the lesions, whereas no change in receptor binding sites was observed. | |||||||||||||||
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In the ventral horn ChAT activity was significantly reduced. | |||||||||||||||
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Decreases in CAT activity following denervation or injection of BTX or TTX were parallel to increases in G6PD activity observed under these conditions. | |||||||||||||||
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Intermittent levodopa treatment further increased GAD activity, decreased CAT activity, restored substance P to control levels, markedly increased dynorphin content, and had no effect on enkephalin. | |||||||||||||||
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These morphologic changes were reflected in a drastic decrease of ChAT activity in cultures treated from day 4 to day 6 but not from 6 to 8. | |||||||||||||||
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Animals treated with IA showed a decrease in the activity of ChAT (-24%), AChE (-36%) and beta-End level (-33%) in the frontoparietal cortex (FC). | |||||||||||||||
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Chronic lipopolysaccharide infusions decreased choline acetyltransferase activity and increased the number of activated microglia within the basal forebrain region. | |||||||||||||||
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The efficacy of lesioning was confirmed by the observation of a significant decrease in choline acetyltransferase (ChAT) activity in the ipsilateral prefrontal cortex. | |||||||||||||||
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The drug also significantly restored decreases in cortical choline acetyltransferase (p < 0.05) and hippocampal glutamic acid decarboxylase activities (p < 0.01) in the embolized cerebral hemisphere and significantly increased cortical choline acetyltransferase (p < 0.05) and acetylcholinesterase activities (p < 0.05) in the contralateral cerebral hemisphere 21 days after embolization. | |||||||||||||||
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Hippocampal ChAT activity was found to be reduced both 30 and 60 min after injection of the higher concentration of formalin but only 30 min after the lower one. | |||||||||||||||
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These effects were decreases in norepinephrine uptake and in choline acetyltransferase activity, both markers of nerve terminal function. | |||||||||||||||
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Bilateral neonatal FR lesions resulted in a permanent loss of ChAT and cytochrome oxidase staining throughout the IPN and of SP in the lateral and rostral subnuclei. | |||||||||||||||
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Characteristic axodendritic synapses in the rostral, intermediate and central subnuclei possessed ChAT immunoreactivity presynaptically, and AChE reactivity both pre- and postsynaptically. | |||||||||||||||
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After distal axotomy, without apparent neurodegeneration such as cell loss and decreased ChaT-immunoreactivity, increased levels of APP expression were observed in the spinal cords of aged rats post-injury. | |||||||||||||||
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In contrast to morphine, exposure to 10(-6) M methadone from day 4 to day 6 resulted in reduced ChAT activity but the growth pattern of the cultures remained morphologically intact. | |||||||||||||||
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Insulin treatment reversibly reduced ChAT activity in cultures plated at densities of greater than 4,000 cells/mm2, and the extent of this reduction increased with increasing cell density. | |||||||||||||||
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Lesions of the FR eliminated all ChAT from the IPN while lesions of the stria medullaris produced a modest decrease. | |||||||||||||||
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General Comments
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