INT6381

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Context Info
Confidence 0.59
First Reported 1982
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 51
Total Number 52
Disease Relevance 19.68
Pain Relevance 15.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Chat) transferase activity, transferring acyl groups (Chat)
Anatomy Link Frequency
cortex 6
hippocampus 4
motoneurons 2
IPN 2
cholinergic neurons 2
Chat (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 51 100.00 Very High Very High Very High
Neurotransmitter 40 100.00 Very High Very High Very High
Pain 30 100.00 Very High Very High Very High
Enkephalin 15 100.00 Very High Very High Very High
dopamine receptor 3 100.00 Very High Very High Very High
Nerve growth factor 166 99.80 Very High Very High Very High
Spinal cord 8 99.70 Very High Very High Very High
Hippocampus 57 99.68 Very High Very High Very High
Nucleus accumbens 9 99.68 Very High Very High Very High
IPN 18 99.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Generalized Anxiety Disorder 10 100.00 Very High Very High Very High
Death 167 99.54 Very High Very High Very High
Disease 650 99.50 Very High Very High Very High
Cognitive Disorder 186 99.38 Very High Very High Very High
Apoptosis 326 99.32 Very High Very High Very High
Stress 142 99.26 Very High Very High Very High
Diabetes Mellitus 11 99.16 Very High Very High Very High
Pain 21 98.80 Very High Very High Very High
Increased Venous Pressure Under Development 13 98.80 Very High Very High Very High
Diverticulitis 87 98.30 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Results indicate that the decrease in ChAT activity depends upon the presence of the nociceptive input rather than its magnitude.
Negative_regulation (decrease) of ChAT associated with nociception
1) Confidence 0.59 Published 1993 Journal Brain Res. Section Abstract Doc Link 8287273 Disease Relevance 0.26 Pain Relevance 0.25
Decrease of hippocampal choline acetyltransferase activity induced by formalin pain.
Negative_regulation (Decrease) of choline acetyltransferase associated with pain
2) Confidence 0.59 Published 1993 Journal Brain Res. Section Title Doc Link 8287273 Disease Relevance 0.27 Pain Relevance 0.57
Confirming earlier results, an almost total depletion of ChAT was obtained in the IPN following complete FR lesions at any survival day studied.
Negative_regulation (depletion) of ChAT in IPN associated with ipn
3) Confidence 0.59 Published 1990 Journal Brain Res. Bull. Section Abstract Doc Link 2271960 Disease Relevance 0 Pain Relevance 0.71
After a unilateral spinal cord lesion at C3, ChAT activity was reduced in the ipsilateral ventral horn at C6-7 caudal to the lesions, whereas no change in receptor binding sites was observed.
Negative_regulation (reduced) of ChAT in horn associated with spinal cord
4) Confidence 0.58 Published 1986 Journal Acta Physiol. Scand. Section Abstract Doc Link 3012950 Disease Relevance 0 Pain Relevance 0.37
In the ventral horn ChAT activity was significantly reduced.
Negative_regulation (reduced) of ChAT in ventral
5) Confidence 0.58 Published 1986 Journal Acta Physiol. Scand. Section Abstract Doc Link 3012950 Disease Relevance 0 Pain Relevance 0.38
Decreases in CAT activity following denervation or injection of BTX or TTX were parallel to increases in G6PD activity observed under these conditions.
Negative_regulation (Decreases) of CAT associated with tetrodotoxin
6) Confidence 0.57 Published 1982 Journal J. Neurochem. Section Abstract Doc Link 7108545 Disease Relevance 0 Pain Relevance 0.39
Intermittent levodopa treatment further increased GAD activity, decreased CAT activity, restored substance P to control levels, markedly increased dynorphin content, and had no effect on enkephalin.
Negative_regulation (decreased) of CAT associated with dynorphin, generalized anxiety disorder, enkephalin and substance p
7) Confidence 0.57 Published 1991 Journal Brain Res. Section Abstract Doc Link 1717109 Disease Relevance 0.26 Pain Relevance 0.71
These morphologic changes were reflected in a drastic decrease of ChAT activity in cultures treated from day 4 to day 6 but not from 6 to 8.
Negative_regulation (decrease) of ChAT
8) Confidence 0.56 Published 1986 Journal Int. J. Dev. Neurosci. Section Abstract Doc Link 3455591 Disease Relevance 0 Pain Relevance 0.65
Animals treated with IA showed a decrease in the activity of ChAT (-24%), AChE (-36%) and beta-End level (-33%) in the frontoparietal cortex (FC).
Negative_regulation (decrease) of ChAT in cortex
9) Confidence 0.55 Published 1992 Journal Brain Res. Section Abstract Doc Link 1611500 Disease Relevance 0.14 Pain Relevance 0.40
Chronic lipopolysaccharide infusions decreased choline acetyltransferase activity and increased the number of activated microglia within the basal forebrain region.
Negative_regulation (decreased) of choline acetyltransferase in forebrain
10) Confidence 0.54 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10940360 Disease Relevance 0.58 Pain Relevance 0.21
The efficacy of lesioning was confirmed by the observation of a significant decrease in choline acetyltransferase (ChAT) activity in the ipsilateral prefrontal cortex.
Negative_regulation (decrease) of ChAT in cortex
11) Confidence 0.51 Published 1992 Journal Brain Res. Section Abstract Doc Link 1327399 Disease Relevance 0 Pain Relevance 0.45
The drug also significantly restored decreases in cortical choline acetyltransferase (p < 0.05) and hippocampal glutamic acid decarboxylase activities (p < 0.01) in the embolized cerebral hemisphere and significantly increased cortical choline acetyltransferase (p < 0.05) and acetylcholinesterase activities (p < 0.05) in the contralateral cerebral hemisphere 21 days after embolization.
Negative_regulation (decreases) of choline acetyltransferase in cerebral hemisphere
12) Confidence 0.44 Published 1992 Journal Arzneimittelforschung Section Abstract Doc Link 1492838 Disease Relevance 0.38 Pain Relevance 0.29
Hippocampal ChAT activity was found to be reduced both 30 and 60 min after injection of the higher concentration of formalin but only 30 min after the lower one.
Negative_regulation (reduced) of ChAT
13) Confidence 0.43 Published 1993 Journal Brain Res. Section Abstract Doc Link 8287273 Disease Relevance 0.25 Pain Relevance 0.24
These effects were decreases in norepinephrine uptake and in choline acetyltransferase activity, both markers of nerve terminal function.
Negative_regulation (decreases) of choline acetyltransferase in nerve
14) Confidence 0.43 Published 1989 Journal Diabetes Section Abstract Doc Link 2563711 Disease Relevance 0.95 Pain Relevance 0.10
Bilateral neonatal FR lesions resulted in a permanent loss of ChAT and cytochrome oxidase staining throughout the IPN and of SP in the lateral and rostral subnuclei.
Negative_regulation (loss) of ChAT in lateral associated with ipn and substance p
15) Confidence 0.42 Published 1987 Journal Brain Res. Section Abstract Doc Link 2445414 Disease Relevance 0 Pain Relevance 0.65
Characteristic axodendritic synapses in the rostral, intermediate and central subnuclei possessed ChAT immunoreactivity presynaptically, and AChE reactivity both pre- and postsynaptically.
Negative_regulation (possessed) of ChAT in synapses
16) Confidence 0.42 Published 1990 Journal Brain Res. Bull. Section Abstract Doc Link 2337826 Disease Relevance 0 Pain Relevance 0.39
After distal axotomy, without apparent neurodegeneration such as cell loss and decreased ChaT-immunoreactivity, increased levels of APP expression were observed in the spinal cords of aged rats post-injury.
Negative_regulation (decreased) of ChaT in spinal cords associated with injury
17) Confidence 0.41 Published 2003 Journal J. Neurosci. Res. Section Abstract Doc Link 12898540 Disease Relevance 0.50 Pain Relevance 0
In contrast to morphine, exposure to 10(-6) M methadone from day 4 to day 6 resulted in reduced ChAT activity but the growth pattern of the cultures remained morphologically intact.
Negative_regulation (reduced) of ChAT associated with methadone and morphine
18) Confidence 0.41 Published 1986 Journal Int. J. Dev. Neurosci. Section Abstract Doc Link 3455591 Disease Relevance 0 Pain Relevance 0.67
Insulin treatment reversibly reduced ChAT activity in cultures plated at densities of greater than 4,000 cells/mm2, and the extent of this reduction increased with increasing cell density.
Negative_regulation (reduced) of ChAT
19) Confidence 0.40 Published 1992 Journal J. Neurochem. Section Abstract Doc Link 1629717 Disease Relevance 0.37 Pain Relevance 0.50
Lesions of the FR eliminated all ChAT from the IPN while lesions of the stria medullaris produced a modest decrease.
Negative_regulation (eliminated) of ChAT in IPN associated with ipn
20) Confidence 0.38 Published 1987 Journal Brain Res. Section Abstract Doc Link 2445413 Disease Relevance 0 Pain Relevance 0.53

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