INT64158

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Context Info
Confidence 0.59
First Reported 1996
Last Reported 2011
Negated 2
Speculated 5
Reported most in Abstract
Documents 121
Total Number 126
Disease Relevance 29.80
Pain Relevance 88.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Prkca) endoplasmic reticulum (Prkca) enzyme binding (Prkca)
protein complex (Prkca) cytoplasm (Prkca) cytosol (Prkca)
Anatomy Link Frequency
platelet 5
hippocampus 3
sciatic nerve 3
brain 2
cerebellum 2
Prkca (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 4715 100.00 Very High Very High Very High
tolerance 299 100.00 Very High Very High Very High
opioid receptor 211 100.00 Very High Very High Very High
Pain 189 100.00 Very High Very High Very High
Hippocampus 55 100.00 Very High Very High Very High
cerebral cortex 41 100.00 Very High Very High Very High
intrathecal 26 100.00 Very High Very High Very High
sSRI 182 99.98 Very High Very High Very High
Morphine 619 99.96 Very High Very High Very High
narcan 42 99.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 71 100.00 Very High Very High Very High
Apoptosis 68 100.00 Very High Very High Very High
Virus Diseases 282 99.98 Very High Very High Very High
Targeted Disruption 244 99.84 Very High Very High Very High
Nervous System Injury 40 99.82 Very High Very High Very High
Hyperalgesia 121 99.54 Very High Very High Very High
Adhesions 173 99.14 Very High Very High Very High
Morphine Dependence 28 99.08 Very High Very High Very High
Thrombosis 646 98.92 Very High Very High Very High
Pain 179 98.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Prenatal exposure to heroin in mice induced global hyperactivation both pre- and post-synaptic along the septohippocampal cholinergic innervation, including basal protein kinase C (PKC) activity accompanied by a desensitization of PKC activity in response to cholinergic agonist.
Negative_regulation (desensitization) of PKC associated with kinase c and agonist
1) Confidence 0.59 Published 2003 Journal Int. J. Neuropsychopharmacol. Section Abstract Doc Link 12974992 Disease Relevance 0.14 Pain Relevance 0.89
When compared to saline-treated controls, PKC activity was increased significantly (P < 0.0005) in procaine- and tetracaine-treated groups whereas ethanol decreased PKC activity.
Negative_regulation (decreased) of PKC associated with kinase c
2) Confidence 0.59 Published 1996 Journal Anesth. Analg. Section Abstract Doc Link 8780278 Disease Relevance 0 Pain Relevance 1.13
But no similar changes in hippocampus and cerebellum were observed. (2) Cytosolic PKC activity was significantly increased in cerebellum and cerebral cortex but decreased in striatum.
Negative_regulation (decreased) of PKC in striatum associated with hippocampus and cerebral cortex
3) Confidence 0.58 Published 1998 Journal Yao Xue Xue Bao Section Abstract Doc Link 12016940 Disease Relevance 0.25 Pain Relevance 0.93
The second experiment was to investigate whether direct inhibition of spinal PKC by intrathecal (i.t.) administration of a specific PKC inhibitor, 2-[8-[(dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-3-yl]-3-(1-methyl-1H-indole-3-yl)maleimide (RO-32-0432), could affect the rewarding effect induced by morphine following sciatic nerve ligation in mice.
Spec (whether) Negative_regulation (inhibition) of PKC in sciatic nerve associated with kinase c, sciatic nerve, morphine and intrathecal
4) Confidence 0.58 Published 2004 Journal Neuroscience Section Abstract Doc Link 15099668 Disease Relevance 0.43 Pain Relevance 1.22
Pseudosubstrate and receptors for activated C-kinase (RACK) peptides inhibit only a single PKC isoform, while previously tested chemical PKC inhibitors simultaneously inhibit multiple isoforms making it impossible to determine which PKC isoform mediates morphine tolerance.
Negative_regulation (inhibit) of PKC associated with tolerance and morphine
5) Confidence 0.58 Published 2007 Journal Pain Section Abstract Doc Link 16965856 Disease Relevance 0 Pain Relevance 0.77
Morphine antinociceptive tolerance in the tail-flick test is completely reversed by inhibitors of protein kinase C (PKC) or cAMP-dependent protein kinase (PKA).
Negative_regulation (inhibitors) of PKC in tail associated with kinase c, tail-flick, tolerance, antinociceptive and morphine
6) Confidence 0.56 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15178359 Disease Relevance 0.16 Pain Relevance 0.81
The present study aimed at evaluating whether pre-treating mice with a PKC or PKA inhibitor prior to pellet implantation would prevent the development of morphine tolerance and physical dependence.
Negative_regulation (inhibitor) of PKC associated with kinase c, physical dependence, tolerance and morphine
7) Confidence 0.55 Published 2008 Journal Brain Res. Section Abstract Doc Link 18501877 Disease Relevance 0.26 Pain Relevance 1.44
We previously demonstrated that chemical inhibitors of protein kinase C (PKC) and A (PKA) are able to reverse morphine tolerance in acutely morphine-challenged mice.
Negative_regulation (inhibitors) of PKC associated with kinase c, tolerance and morphine
8) Confidence 0.55 Published 2006 Journal Pharmacol. Res. Section Abstract Doc Link 17056270 Disease Relevance 0.09 Pain Relevance 1.34
I.c.v. pretreatment with either calphostin C, a PKC inhibitor, or KT-5720, a PKA inhibitor, attenuated naloxone-precipitated withdrawal jumps in morphine-dependent non-diabetic mice.
Negative_regulation (inhibitor) of PKC associated with kinase c, diabetes mellitus, narcan, withdrawal and morphine
9) Confidence 0.54 Published 1999 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 10230858 Disease Relevance 0.78 Pain Relevance 1.56
The PKC beta(I), beta(II), delta, theta, epsilon, eta and xi inhibitors were inactive.
Negative_regulation (inhibitors) of PKC
10) Confidence 0.51 Published 2007 Journal Pain Section Abstract Doc Link 16965856 Disease Relevance 0 Pain Relevance 1.52
An intracerebroventricular injection of calphostin C, a specific PKC inhibitor, produced a dose-dependent reduction in the morphine-induced place preference.
Negative_regulation (inhibitor) of PKC associated with kinase c, intracerebroventricular and morphine
11) Confidence 0.50 Published 2001 Journal Neuroscience Section Abstract Doc Link 11246146 Disease Relevance 0 Pain Relevance 0.66
On the other hand, the PRE-induced increase in the number of spinal pNR1-ir neurons was only blocked by inhibitors of the PKCalpha and PKCepsilon isoforms, but not the PKCzeta isoform.
Negative_regulation (inhibitors) of PKCalpha in neurons
12) Confidence 0.49 Published 2010 Journal Neurosci. Lett. Section Abstract Doc Link 20417251 Disease Relevance 0.31 Pain Relevance 0.87
exhibit defects in LTP and learning [50], and impaired PKC activity has been associated with several neurobehavioral disorders and with neurodegenerative diseases such as Alzheimer's disease [51,52].
Negative_regulation (impaired) of PKC associated with kinase c, long-term potentiation, disease, neurodegenerative disease and neurobehavioral
13) Confidence 0.46 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1401496 Disease Relevance 1.02 Pain Relevance 0.52
PKC inhibition with chelerythrine was ineffective in CM hearts while completely abrogating AM preconditioning.
Negative_regulation (inhibition) of PKC in hearts associated with morphine
14) Confidence 0.45 Published 2006 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 16731654 Disease Relevance 0.31 Pain Relevance 1.05
In order to investigate the direct involvement of PKC in the morphine-induced hyperlocomotion, the locomotion induced by acute morphine treatment in the presence or absence of a PKC inhibitor was measured.
Negative_regulation (inhibitor) of PKC associated with kinase c and morphine
15) Confidence 0.43 Published 2002 Journal Neuroscience Section Abstract Doc Link 11955717 Disease Relevance 0 Pain Relevance 1.34
By inducing morphine dependence in mice, changes in inositol phosphate contents, protein kinase C(PKC) activity in brain regions and effect of PKC inhibitor on the development of morphine dependence were investigated.
Negative_regulation (inhibitor) of PKC in brain associated with addiction, kinase c and morphine
16) Confidence 0.43 Published 1998 Journal Yao Xue Xue Bao Section Abstract Doc Link 12016940 Disease Relevance 0.20 Pain Relevance 0.60
The membrane PKC activity was apparently enhanced in striatum but decreased in cerebellum and hippocampus. (3) PKC inhibitor was found to prevent the development of morphine dependence. (4) These changes described above were not observed in mice treated with naloxone 30 min prior to daily morphine injection.
Negative_regulation (decreased) of PKC in hippocampus associated with addiction, narcan, hippocampus and morphine
17) Confidence 0.43 Published 1998 Journal Yao Xue Xue Bao Section Abstract Doc Link 12016940 Disease Relevance 0.25 Pain Relevance 0.96
The membrane PKC activity was apparently enhanced in striatum but decreased in cerebellum and hippocampus. (3) PKC inhibitor was found to prevent the development of morphine dependence. (4) These changes described above were not observed in mice treated with naloxone 30 min prior to daily morphine injection.
Negative_regulation (inhibitor) of PKC in hippocampus associated with addiction, narcan, hippocampus and morphine
18) Confidence 0.43 Published 1998 Journal Yao Xue Xue Bao Section Abstract Doc Link 12016940 Disease Relevance 0.25 Pain Relevance 0.95
By inducing morphine dependence in mice, changes in inositol phosphate contents, protein kinase C(PKC) activity in brain regions and effect of PKC inhibitor on the development of morphine dependence were investigated.
Negative_regulation (inhibitor) of PKC in brain associated with addiction, kinase c and morphine
19) Confidence 0.43 Published 1998 Journal Yao Xue Xue Bao Section Abstract Doc Link 12016940 Disease Relevance 0.20 Pain Relevance 0.60
The second experiment was to investigate whether direct inhibition of spinal PKC by intrathecal (i.t.) administration of a specific PKC inhibitor, 2-[8-[(dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-3-yl]-3-(1-methyl-1H-indole-3-yl)maleimide (RO-32-0432), could affect the rewarding effect induced by morphine following sciatic nerve ligation in mice.
Negative_regulation (inhibitor) of PKC in sciatic nerve associated with kinase c, sciatic nerve, morphine and intrathecal
20) Confidence 0.43 Published 2004 Journal Neuroscience Section Abstract Doc Link 15099668 Disease Relevance 0.45 Pain Relevance 1.27

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