INT64164

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Context Info
Confidence 0.62
First Reported 1996
Last Reported 2010
Negated 4
Speculated 9
Reported most in Abstract
Documents 34
Total Number 43
Disease Relevance 10.44
Pain Relevance 30.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Prkca) endoplasmic reticulum (Prkca) enzyme binding (Prkca)
protein complex (Prkca) cytoplasm (Prkca) cytosol (Prkca)
Anatomy Link Frequency
brain 4
spinal cord 3
neurons 2
mesenteric vein 1
platelet 1
Prkca (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 897 100.00 Very High Very High Very High
Morphine 266 100.00 Very High Very High Very High
local anesthetic 4 100.00 Very High Very High Very High
Physical dependence 2 100.00 Very High Very High Very High
Inflammation 127 99.92 Very High Very High Very High
addiction 34 99.80 Very High Very High Very High
Clonidine 48 99.78 Very High Very High Very High
Spinal cord 30 99.72 Very High Very High Very High
antinociception 18 99.52 Very High Very High Very High
nMDA receptor 42 99.46 Very High Very High Very High
Disease Link Frequency Relevance Heat
Drug Dependence 2 100.00 Very High Very High Very High
INFLAMMATION 140 99.92 Very High Very High Very High
Morphine Dependence 12 99.80 Very High Very High Very High
Insulin Resistance 59 99.68 Very High Very High Very High
Disease 320 99.36 Very High Very High Very High
Pain 29 99.14 Very High Very High Very High
Hyperalgesia 14 98.68 Very High Very High Very High
Neurodegenerative Disease 37 98.24 Very High Very High Very High
Increased Venous Pressure Under Development 70 98.00 Very High Very High Very High
Hyperinsulinism 15 97.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To determine whether chronic morphine or clonidine treatment alters spinal PKC activity, the present studies measured PKC activity and expression of PKC isoform proteins in spinal cord cytosol and membrane fractions.
Spec (whether) Regulation (alters) of PKC in spinal cord associated with kinase c, spinal cord, clonidine and morphine
1) Confidence 0.62 Published 1999 Journal Biochem. Pharmacol. Section Abstract Doc Link 10424770 Disease Relevance 0 Pain Relevance 2.00
These data on the effects of local anesthetics on PKC activity and c-Fos in vivo are of relevance for studies aimed at delineating the biochemical basis of spinal and epidural anesthesia.
Regulation (effects) of PKC in spinal associated with anesthesia, kinase c, epidural and local anesthetic
2) Confidence 0.62 Published 1996 Journal Anesth. Analg. Section Abstract Doc Link 8780278 Disease Relevance 0 Pain Relevance 1.13
The present study was then designed to examine the changes in G(q/11alpha) and G(betagamma) subunits and PKC activity on sensitization to the morphine-induced hyperlocomotion.
Spec (examine) Regulation (changes) of PKC associated with kinase c and morphine
3) Confidence 0.62 Published 2002 Journal Neuroscience Section Abstract Doc Link 11955717 Disease Relevance 0 Pain Relevance 0.76
By contrast, there were no changes in the protein level of all five PKC isoforms in the lower midbrain.
Neg (no) Regulation (changes) of PKC in midbrain associated with kinase c and midbrain
4) Confidence 0.52 Published 2001 Journal Neuroscience Section Abstract Doc Link 11246146 Disease Relevance 0.08 Pain Relevance 0.97
These peptides were tested for their effect on PKC activity in cells in vivo and in an ex vivo model of acute ischemic heart disease.
Regulation (effect) of PKC in heart associated with kinase c and coronary artery disease
5) Confidence 0.51 Published 2007 Journal J. Biol. Chem. Section Abstract Doc Link 17142835 Disease Relevance 0.41 Pain Relevance 0.53
To determine whether chronic morphine or clonidine treatment alters spinal PKC activity, the present studies measured PKC activity and expression of PKC isoform proteins in spinal cord cytosol and membrane fractions.
Regulation (activity) of PKC in spinal cord associated with kinase c, spinal cord, clonidine and morphine
6) Confidence 0.45 Published 1999 Journal Biochem. Pharmacol. Section Abstract Doc Link 10424770 Disease Relevance 0 Pain Relevance 2.07
Fluoxetine action on murine T-lymphocyte proliferation: participation of PKC activation and calcium mobilisation.
Regulation (participation) of PKC in T-lymphocyte associated with fluoxetine
7) Confidence 0.45 Published 1998 Journal Cell. Signal. Section Title Doc Link 9884023 Disease Relevance 0.09 Pain Relevance 0.59
[Effects of chronic morphine treatment on inositol phosphates contents and PKC activity in mouse brain].
Regulation ([Effects) of PKC in brain associated with morphine
8) Confidence 0.45 Published 1998 Journal Yao Xue Xue Bao Section Title Doc Link 12016940 Disease Relevance 0.26 Pain Relevance 0.90
[Effects of chronic morphine treatment on inositol phosphates contents and PKC activity in mouse brain].
Regulation (contents) of PKC in brain associated with morphine
9) Confidence 0.45 Published 1998 Journal Yao Xue Xue Bao Section Title Doc Link 12016940 Disease Relevance 0.26 Pain Relevance 0.90
The involvement of cyclic AMP-dependent protein kinase (PKA) and protein kinase C (PKC) in the modulation of naloxone-precipitated withdrawal jumping in morphine-dependent mice by diabetes was examined.
Spec (examined) Regulation (involvement) of PKC associated with kinase c, diabetes mellitus, narcan, withdrawal and morphine
10) Confidence 0.42 Published 1999 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 10230858 Disease Relevance 0.46 Pain Relevance 1.04
However, the protein levels of PKCalpha, betaI, betaII and epsilon were not affected in the same preparation.
Neg (not) Regulation (affected) of PKCalpha
11) Confidence 0.38 Published 2001 Journal Neuroscience Section Abstract Doc Link 11246146 Disease Relevance 0.07 Pain Relevance 0.95
The present study was designed to investigate the role of protein kinase C (PKC) isoform in the morphine-induced reinforcing effect in mice.
Spec (investigate) Regulation (role) of PKC associated with kinase c and morphine
12) Confidence 0.38 Published 2001 Journal Neuroscience Section Abstract Doc Link 11246146 Disease Relevance 0 Pain Relevance 0.55
The sodium-restricting response to a low-sodium diet was unaffected in PKC-alpha -/- mice.
Neg (unaffected) Regulation (unaffected) of PKC-alpha associated with kinase c
13) Confidence 0.37 Published 2004 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 15039142 Disease Relevance 0.08 Pain Relevance 0.65
These results indicate a role for the PLC-PKC pathway in central H(1)-induced hyperalgesia in mice.
Regulation (role) of PLC-PKC associated with hyperalgesia and kinase c
14) Confidence 0.37 Published 2004 Journal Neuropharmacology Section Abstract Doc Link 15223308 Disease Relevance 0.52 Pain Relevance 0.96
Next, we examined whether protein kinase C (PKC) and the G protein are involved in the action of imipramine on pinacidil induced pacemaker current inhibition.
Spec (whether) Regulation (involved) of PKC associated with kinase c
15) Confidence 0.36 Published 2006 Journal Life Sci. Section Abstract Doc Link 16266721 Disease Relevance 0.11 Pain Relevance 0.36
Thus, changes in PKC signaling and in presynaptic potentiation observed in BDV-infected neurons could critically affect learning and behavior.
Regulation (changes) of PKC in neurons associated with virus diseases and kinase c
16) Confidence 0.36 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1401496 Disease Relevance 1.03 Pain Relevance 0.48
As captured in the network, genes for partners of PTK2B were also up-regulated in Glud1 hippocampal neurons, including the protein kinase Prkca and the small GTPase Rac1 (RAS-Related C3 Botulinum Substrate 1).


Regulation (regulated) of Prkca in neurons
17) Confidence 0.35 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2896956 Disease Relevance 0.07 Pain Relevance 0.16
The present study was conducted to investigate the involvement of brain protein kinase C (PKC) isoform in these two types of tolerance to N2O-induced antinociception in mice.
Spec (investigate) Regulation (involvement) of PKC in brain associated with antinociception, kinase c and tolerance
18) Confidence 0.35 Published 2007 Journal Neuroscience Section Abstract Doc Link 17681696 Disease Relevance 0 Pain Relevance 1.16
The present study was designed to investigate the role of a protein kinase C (PKC) isoform in the uncoupling of the mu-opioid receptor from G-proteins after repeated intrathecal injection of a selective mu-receptor agonist, [D-Ala(2),N-MePhe(4),Gly-ol(5)]enkephalin (DAMGO), in the spinal cord of mice.
Spec (investigate) Regulation (role) of PKC in spinal cord associated with kinase c, agonist, enkephalin, opioid receptor, spinal cord and intrathecal
19) Confidence 0.33 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11356858 Disease Relevance 0 Pain Relevance 0.71
Peptides derived from the C2 domain of protein kinase C epsilon (epsilon PKC) modulate epsilon PKC activity and identify potential protein-protein interaction surfaces.
Regulation (modulate) of PKC associated with kinase c
20) Confidence 0.33 Published 2007 Journal J. Biol. Chem. Section Title Doc Link 17142835 Disease Relevance 0.19 Pain Relevance 0.45

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