INT64173

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Context Info
Confidence 0.37
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 2.89
Pain Relevance 0.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (GLI2) cell proliferation (GLI2) nucleus (GLI2)
intracellular (GLI2) cilium (GLI2) cytoplasm (GLI2)
Anatomy Link Frequency
macrophages 4
GLI2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 8 100.00 Very High Very High Very High
aspirin 4 93.76 High High
Mechanotransduction 16 83.56 Quite High
COX2 2 25.00 Low Low
Pain 2 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
agonist 1 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 124 100.00 Very High Very High Very High
Medulloblastoma 10 99.28 Very High Very High Very High
Hypertension 2 97.76 Very High Very High Very High
INFLAMMATION 4 92.40 High High
Heart Disease 2 92.40 High High
Repression 3 80.84 Quite High
Metastasis 47 78.96 Quite High
Breast Cancer 12 78.52 Quite High
Osteolysis 6 56.24 Quite High
Advanced Or Metastatic Breast Cancer 2 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mechanical signals induced by substrate rigidity regulate the expression of Gli2 and PTHrP though ROCK.
Regulation (regulate) of Gene_expression (expression) of Gli2
1) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981576 Disease Relevance 0.97 Pain Relevance 0.04
Our observation that the expression of Gli2 by tumor cells is regulated by matrix rigidity is consistent with previous studies suggesting that Hh genes are regulated during development by mechanically transduced signals [43], [44].
Regulation (regulated) of Gene_expression (expression) of Gli2 associated with cancer
2) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981576 Disease Relevance 1.00 Pain Relevance 0.04
Several promising cancer drugs that reduce medulloblastoma growth in mouse models purportedly interfere with Gli1 and Gli2 expression by blocking the signalling pathway downstream of Smo.
Regulation (interfere) of Gene_expression (expression) of Gli2 associated with cancer and medulloblastoma
3) Confidence 0.17 Published 2007 Journal BMC Syst Biol Section Body Doc Link PMC1839891 Disease Relevance 0.58 Pain Relevance 0
In this study we evaluated the effect of several NSAIDs on COX-1 and COX-2 mRNA, protein expression and PGE2 production in PMA-differentiated THP-1 and U937 human macrophages stimulated with LPS.
Regulation (effect) of Gene_expression (expression) of THP-1 in macrophages associated with cinod
4) Confidence 0.10 Published 1996 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 8780708 Disease Relevance 0.17 Pain Relevance 0.40
In this study we evaluated the effect of several NSAIDs on COX-1 and COX-2 mRNA, protein expression and PGE2 production in PMA-differentiated THP-1 and U937 human macrophages stimulated with LPS.
Regulation (effect) of Gene_expression (production) of THP-1 in macrophages associated with cinod
5) Confidence 0.10 Published 1996 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 8780708 Disease Relevance 0.17 Pain Relevance 0.40

General Comments

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