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Context Info
Confidence 0.62
First Reported 1996
Last Reported 2011
Negated 5
Speculated 1
Reported most in Body
Documents 35
Total Number 37
Disease Relevance 27.11
Pain Relevance 1.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Trp53) mitochondrion (Trp53) endoplasmic reticulum (Trp53)
enzyme binding (Trp53) protein complex assembly (Trp53) DNA binding (Trp53)
Anatomy Link Frequency
heart 2
urinary bladder 1
fat 1
brain 1
bladder 1
Trp53 (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 5 91.84 High High
rheumatoid arthritis 67 91.04 High High
antagonist 20 88.88 High High
cINOD 19 85.84 High High
Potency 7 84.36 Quite High
Chronic pancreatitis 4 82.92 Quite High
Inflammation 154 80.88 Quite High
Nerve growth factor 4 79.68 Quite High
agonist 26 75.00 Quite High
medulla 17 73.32 Quite High
Disease Link Frequency Relevance Heat
Cancer 974 100.00 Very High Very High Very High
Apoptosis 675 100.00 Very High Very High Very High
Stress 90 99.78 Very High Very High Very High
Hodgkin's Disease 22 99.76 Very High Very High Very High
Hypoxia 23 99.66 Very High Very High Very High
Myocardial Infarction 4 99.48 Very High Very High Very High
Solid Tumor 22 99.42 Very High Very High Very High
Pancreatic Cancer 58 98.44 Very High Very High Very High
Skin Cancer 16 98.40 Very High Very High Very High
Malignant Neoplastic Disease 90 98.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We must also take into account the function and expression of proteins and microRNAs that regulate p53.
Regulation (regulate) of p53
1) Confidence 0.62 Published 2011 Journal Journal of Oncology Section Body Doc Link PMC3010739 Disease Relevance 0.77 Pain Relevance 0.04
In summary, the data presented indicates that Hr mediates an anti-apoptotic response involving the regulation of p53 and Bcl2 family members.
Regulation (regulation) of p53 associated with apoptosis
2) Confidence 0.55 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944824 Disease Relevance 0.49 Pain Relevance 0
No change in p53 mRNA was observed as measured by RT-PCR and real time PCR (data not shown).
Neg (No) Regulation (change) of p53 mRNA
3) Confidence 0.55 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944824 Disease Relevance 0.77 Pain Relevance 0
This possibility is less likely because no change in p53 mRNA was observed.
Neg (no) Regulation (change) of p53 mRNA
4) Confidence 0.55 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944824 Disease Relevance 0.38 Pain Relevance 0
Also, the nuclear receptor regulating p53 is presently unknown.
Regulation (regulating) of p53
5) Confidence 0.55 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944824 Disease Relevance 0.34 Pain Relevance 0
Solid tumor and cell line expression of keratins, TP53 and HER2
Regulation (keratins) of TP53 associated with solid tumor
6) Confidence 0.41 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2467432 Disease Relevance 0.86 Pain Relevance 0
The introduction of a single mutant p53 allele greatly accelerated MYC's ability to induce tumorigenesis.
Regulation (introduction) of p53
7) Confidence 0.34 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 0.85 Pain Relevance 0
Up-regulation by the high fat diet, has been confirmed for genes encoding: Vegfa, and Trp53.
Regulation (regulation) of Trp53 in fat
8) Confidence 0.32 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2674043 Disease Relevance 1.01 Pain Relevance 0
In a study carried out by Rongen et al., the p53 gene was evaluated in 8 CHL cases and 6 (80%) of them demonstrated p53 gene mutations in their HRS cells [5].
Regulation (evaluated) of p53 associated with hodgkin's disease
9) Confidence 0.31 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC2853498 Disease Relevance 0.82 Pain Relevance 0
Finally, regulation of the p53 pathway by microRNAs is likely to be of importance also in brain tumor development and brain tumor stem cells [122].


Regulation (regulation) of p53 in brain associated with brain tumor
10) Confidence 0.27 Published 2011 Journal Journal of Oncology Section Body Doc Link PMC3010739 Disease Relevance 1.07 Pain Relevance 0
Given the importance of understanding the precise mechanisms of p53 regulation in vivo, our Smyd2 cKO mice will provide a useful tool for gathering such information in the heart as well as other organs.
Regulation (regulation) of p53 in heart
11) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2840034 Disease Relevance 0.65 Pain Relevance 0
The mRNAs investigated in this study were Fas, c-fos, c-myc. bcl-2, and p53, and glyceraldehyde-3-phosphate dehydrogenase mRNA was employed as internal control.
Regulation (control) of p53 in internal
12) Confidence 0.25 Published 1996 Journal Oncology Section Abstract Doc Link 8784477 Disease Relevance 0 Pain Relevance 0.09
Firstly, the p53 in TM10 (p53 wt) cells might have been acetylated upon treatment with 2.5 ?
Spec (might) Regulation (acetylated) of p53
13) Confidence 0.22 Published 2001 Journal Breast Cancer Res Section Body Doc Link PMC13923 Disease Relevance 0 Pain Relevance 0
Over-expression of MIF down regulated p53 levels and suppressed nuclear localization, thereby prohibiting its transcriptional activity.
Regulation (regulated) of p53
14) Confidence 0.21 Published 2010 Journal QJM: An International Journal of Medicine Section Body Doc Link PMC2955282 Disease Relevance 1.27 Pain Relevance 0.16
The relevance of Smyd2 in the heart will be particularly interesting in regard to stress models (myocardial infarction, hypoxia), as functional misregulation of p53 and other stress sensors might be masked under physiologic conditions, becoming apparent only when an acute need is present.
Regulation (misregulation) of p53 in heart associated with stress, hypoxia and myocardial infarction
15) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2840034 Disease Relevance 0.68 Pain Relevance 0
In our series, p53 was positive in high percentage (69.2%, 9/13 cases) of GISTs and 100% (2/2 cases) of GANTs, reflecting the high percentage of high-grade tumors.
Regulation (positive) of p53 associated with cancer
16) Confidence 0.16 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2822305 Disease Relevance 0.73 Pain Relevance 0
Functional screens carried out by Hudson et al.23 to identify cDNAs capable of negatively regulating p53 identified MIF.
Regulation (regulating) of p53
17) Confidence 0.15 Published 2010 Journal QJM: An International Journal of Medicine Section Body Doc Link PMC2955282 Disease Relevance 1.27 Pain Relevance 0.16
The most important functions of p53 are the regulation of the cell cycle, e.g. the G1/S transition, and the induction of apoptosis.
Regulation (regulation) of p53 associated with apoptosis
18) Confidence 0.13 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149419 Disease Relevance 1.13 Pain Relevance 0.20
Further, these studies exhibited a series of mechanistic information including free radical scavenging ability, anti-endonucleolytic activity, cytochrome P450 2E1 inhibitory activity, anti-necrotic, anti-apoptotic and anti-carcinogenic activities, modulatory effects on antioxidative and apoptotic regulatory genes such as Bcl2, c-myc and p53, which may be responsible for the novel chemoprotective properties exhibited by GSPE.
Regulation (effects) of p53 associated with apoptosis
19) Confidence 0.12 Published 2002 Journal Indian J. Exp. Biol. Section Abstract Doc Link 12587719 Disease Relevance 0.58 Pain Relevance 0.07
Of note, decoy receptor-2 (DcR2) a TRAIL-R and a target for p53 siRNA [131], but only in combination with Ad5hTRAIL, eliminated the TRAIL-induced resistance to apoptosis in these cells to a more significant extent than when the cells were transfected with Ad5hTRAIL alone.
Regulation (target) of p53 associated with apoptosis
20) Confidence 0.10 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2842969 Disease Relevance 0.97 Pain Relevance 0.28

General Comments

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