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Context Info
Confidence 0.78
First Reported 1996
Last Reported 2010
Negated 4
Speculated 0
Reported most in Abstract
Documents 66
Total Number 66
Disease Relevance 13.61
Pain Relevance 41.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Pnoc)
Anatomy Link Frequency
brain 6
NS20Y 6
neurites 4
embryonic stages 3
central nervous system 3
Pnoc (Mus musculus)
Pnoc - N27K (5) Pnoc - N23K (5)
Pain Link Frequency Relevance Heat
orphanin 428 100.00 Very High Very High Very High
Neuropeptide 41 100.00 Very High Very High Very High
antagonist 36 100.00 Very High Very High Very High
agonist 35 100.00 Very High Very High Very High
opioid receptor 30 100.00 Very High Very High Very High
Dynorphin 16 100.00 Very High Very High Very High
intrathecal 9 100.00 Very High Very High Very High
Hyperalgesia 21 99.96 Very High Very High Very High
Morphine 9 99.84 Very High Very High Very High
Opioid 58 99.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hyperalgesia 26 99.96 Very High Very High Very High
Stress 14 99.36 Very High Very High Very High
Diabetes Mellitus 14 99.28 Very High Very High Very High
Pruritus 6 98.68 Very High Very High Very High
Nociception 19 98.60 Very High Very High Very High
Neuroblastoma 2 98.00 Very High Very High Very High
Pain 34 97.40 Very High Very High Very High
Targeted Disruption 22 97.36 Very High Very High Very High
Neuropathic Pain 21 96.92 Very High Very High Very High
Parkinson's Disease 8 96.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
N23K and N27K encode precursor proteins for an opioid neuropeptide, nociceptin/orphanin FQ, but the transient expression of N23K and N27K suggests that it may be involved in neuronal differentiation.
Gene_expression (expression) of N27K (N27K) in neuronal associated with orphanin, neuropeptide and opioid
1) Confidence 0.78 Published 1997 Journal J. Neurosci. Res. Section Abstract Doc Link 9185664 Disease Relevance 0 Pain Relevance 0.36
N23K and N27K encode precursor proteins for an opioid neuropeptide, nociceptin/orphanin FQ, but the transient expression of N23K and N27K suggests that it may be involved in neuronal differentiation.
Gene_expression (expression) of N23K (N23K) in neuronal associated with orphanin, neuropeptide and opioid
2) Confidence 0.78 Published 1997 Journal J. Neurosci. Res. Section Abstract Doc Link 9185664 Disease Relevance 0 Pain Relevance 0.36
A moderate level of prepronociceptin messenger RNA expression was observed in the medial preoptic nucleus, ventromedial preoptic nucleus, periventricular nucleus, pedonculopontine tegmental nucleus, solitary tract nucleus and spinal trigeminal nucleus.
Gene_expression (expression) of prepronociceptin in medial preoptic nucleus
3) Confidence 0.78 Published 1999 Journal Neuroscience Section Abstract Doc Link 10391477 Disease Relevance 0.09 Pain Relevance 0.43
The present data confirm that nociceptin is expressed in a broad array of regions of the central nervous system.
Gene_expression (expressed) of nociceptin in central nervous system associated with orphanin and central nervous system
4) Confidence 0.78 Published 1999 Journal Neuroscience Section Abstract Doc Link 10391477 Disease Relevance 0.06 Pain Relevance 0.62
A weak level of prepronociceptin messenger RNA expression was present in some areas, such as the cerebral cortex, endopiriform cortex, hippocampal formation, medial amygdaloid nucleus, anterior hypothalamic area, medial mammillary hypothalamic nuclei, retrorubral field and substantia nigra pars compacta.
Gene_expression (expression) of prepronociceptin in cerebral cortex associated with substantia nigra and cerebral cortex
5) Confidence 0.78 Published 1999 Journal Neuroscience Section Abstract Doc Link 10391477 Disease Relevance 0.08 Pain Relevance 0.55
Whereas this treatment markedly reduced the content of substance P in the spinal cord, it did not affect the nociceptin content or the expression of nociceptin receptors and GluRvarepsilon and GluRzeta subunits of N-methyl-D-aspartate receptors in it.
Gene_expression (expression) of nociceptin in spinal cord associated with nmda receptor, orphanin, spinal cord and substance p
6) Confidence 0.77 Published 2000 Journal Neuroscience Section Abstract Doc Link 10771345 Disease Relevance 1.31 Pain Relevance 2.34
Dot blot analysis showed that the antibodies selectively detect nociceptin but not dynorphin or other opioid peptides.
Gene_expression (detect) of nociceptin associated with dynorphin, orphanin and opioid
7) Confidence 0.76 Published 1996 Journal Neuroreport Section Abstract Doc Link 9116232 Disease Relevance 0.26 Pain Relevance 1.01
Overexpression of a neuropeptide nociceptin/orphanin FQ precursor gene, N23K/N27K, induces neurite outgrowth in mouse NS20Y cells.
Gene_expression (Overexpression) of neuropeptide nociceptin in NS20Y associated with orphanin and neuropeptide
8) Confidence 0.75 Published 1997 Journal J. Neurosci. Res. Section Title Doc Link 9185664 Disease Relevance 0 Pain Relevance 0.42
In 6-hydroxydopamine hemilesioned rats, enhancement of N/OFQ expression and release was detected in the lesioned compared with the unlesioned SN, indicating that parkinsonism may be associated with overactivation of the N/OFQ-NOP receptor system in the SN.
Gene_expression (expression) of N/OFQ associated with parkinson's disease and substantia nigra
9) Confidence 0.75 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 16237164 Disease Relevance 0.59 Pain Relevance 0.85
Our results show that nocistatin is a new biologically active peptide produced from the same precursor as nociceptin and indicate that these two peptides may play opposite roles in pain transmission.
Gene_expression (produced) of nociceptin associated with pain and orphanin
10) Confidence 0.70 Published 1998 Journal Nature Section Abstract Doc Link 9521323 Disease Relevance 0.97 Pain Relevance 1.44
Functional selectivity of orphanin FQ for its receptor coexpressed with potassium channel subunits in Xenopus laevis oocytes.
Gene_expression (coexpressed) of orphanin FQ in oocytes associated with orphanin and potassium channel
11) Confidence 0.69 Published 1996 Journal Mol. Pharmacol. Section Title Doc Link 8794880 Disease Relevance 0 Pain Relevance 0.85
Nociceptin and dynorphin A(1-17) produce antianalgesia through independent systems in mice.
Gene_expression (produce) of Nociceptin associated with dynorphin and orphanin
12) Confidence 0.69 Published 2002 Journal Life Sci. Section Title Doc Link 11860156 Disease Relevance 0 Pain Relevance 0.58
In addition, the neurites of transfectants that expressed both N23K and N27K were longer than those of the transfectants that expressed N23K or N27K alone.
Gene_expression (expressed) of N27K (N27K) in neurites
13) Confidence 0.68 Published 1997 Journal J. Neurosci. Res. Section Abstract Doc Link 9185664 Disease Relevance 0 Pain Relevance 0.29
In addition, the neurites of transfectants that expressed both N23K and N27K were longer than those of the transfectants that expressed N23K or N27K alone.
Gene_expression (expressed) of N23K (N23K) in neurites
14) Confidence 0.68 Published 1997 Journal J. Neurosci. Res. Section Abstract Doc Link 9185664 Disease Relevance 0 Pain Relevance 0.29
High to moderate levels of prepronociceptin messenger RNA expression were detected in the lateral, ventral and medial septum, and were evident in brainstem structures implicated in descending antinociceptive pathways (e.g., the gigantocellular nucleus, raphe magnus nucleus, periaqueductal gray matter), and also observed in association with auditory relay nuclei such as the inferior colliculi, lateral lemniscus nucleus, medioventral preolivary nucleus and lateral superior nucleus.
Gene_expression (expression) of prepronociceptin in lateral lemniscus nucleus associated with raphe magnus, medulla, central grey and antinociceptive
15) Confidence 0.68 Published 1999 Journal Neuroscience Section Abstract Doc Link 10391477 Disease Relevance 0.09 Pain Relevance 0.37
We recently discovered N23K and its splicing variant N27K as transcripts upregulated in mouse NS20Y cells after differentiation induced by dibutylyl cyclic AMP (dbcAMP) treatment.
Gene_expression (discovered) of N23K (N23K) in NS20Y
16) Confidence 0.68 Published 1997 Journal J. Neurosci. Res. Section Abstract Doc Link 9185664 Disease Relevance 0 Pain Relevance 0.32
Overexpression of a neuropeptide nociceptin/orphanin FQ precursor gene, N23K/N27K, induces neurite outgrowth in mouse NS20Y cells.
Gene_expression (Overexpression) of N23K (N23K) in NS20Y associated with orphanin and neuropeptide
17) Confidence 0.68 Published 1997 Journal J. Neurosci. Res. Section Title Doc Link 9185664 Disease Relevance 0 Pain Relevance 0.42
Distribution of the nociceptin and nocistatin precursor transcript in the mouse central nervous system.
Gene_expression (Distribution) of nociceptin in central nervous system associated with orphanin and central nervous system
18) Confidence 0.68 Published 1999 Journal Neuroscience Section Title Doc Link 10391477 Disease Relevance 0.05 Pain Relevance 0.34
Intraplantar injection of the nociceptin (1-7) fragment had no effect on capsaicin-induced nociception.
Gene_expression (injection) of nociceptin associated with nociception, qutenza and orphanin
19) Confidence 0.67 Published 2005 Journal Peptides Section Abstract Doc Link 16006010 Disease Relevance 0.32 Pain Relevance 1.29
The results suggest that nociceptin acts on ORL1 receptor on the keratinocytes to produce leukotriene B(4), which induces itch-associated responses in mice.
Gene_expression (produce) of nociceptin in keratinocytes associated with orphanin and pruritus
20) Confidence 0.67 Published 2004 Journal J. Invest. Dermatol. Section Abstract Doc Link 15191560 Disease Relevance 0.29 Pain Relevance 0.56

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