INT6463

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Context Info
Confidence 0.01
First Reported 1992
Last Reported 1992
Negated 1
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Oprd1, Npr1) intracellular (Npr1) cytoplasm (Oprd1)
signal transducer activity (Oprd1)
Oprd1 (Rattus norvegicus)
Npr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 4 100.00 Very High Very High Very High
mu opioid receptor 1 100.00 Very High Very High Very High
Dopamine 1 100.00 Very High Very High Very High
Somatostatin 1 99.76 Very High Very High Very High
Enkephalin 2 97.94 Very High Very High Very High
opioid receptor 4 96.00 Very High Very High Very High
Delta opioid receptors 1 83.28 Quite High
narcan 1 37.04 Quite Low
Neurotransmitter 1 33.68 Quite Low

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In concentrations that antagonized the presynaptic inhibitory effect of [D-Ala2,MePhe4,Gly-ol5]enkephalin (DAMGO) on [3H]norepinephrine release from rat neocortical slices, the cyclic somatostatin-related mu opioid receptor antagonist D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 did not affect the inhibition of dopamine-sensitive adenylate cyclase caused by DAMGO in neostriatal slices.
opioid receptor Neg (not) Regulation (affect) of Negative_regulation (inhibition) of cyclase associated with dopamine, antagonist, mu opioid receptor, somatostatin and enkephalin
1) Confidence 0.01 Published 1992 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1328606 Disease Relevance 0 Pain Relevance 0.63

General Comments

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