INT64653

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Context Info
Confidence 0.44
First Reported 1996
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 17
Total Number 17
Disease Relevance 6.74
Pain Relevance 4.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (CD2) plasma membrane (CD2)
Anatomy Link Frequency
T cell 8
effector T lymphocytes 2
macrophages 1
accessory cells 1
leukocyte 1
CD2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuritis 9 99.52 Very High Very High Very High
Inflammation 139 99.08 Very High Very High Very High
Arthritis 251 98.88 Very High Very High Very High
Acupuncture 280 97.84 Very High Very High Very High
psoriasis 362 97.48 Very High Very High Very High
Enkephalin 16 97.12 Very High Very High Very High
rheumatoid arthritis 80 92.64 High High
Adalimumab 38 90.16 High High
methotrexate 29 89.60 High High
cytokine 149 83.80 Quite High
Disease Link Frequency Relevance Heat
Experimental Autoimmune Neuritis 9 99.52 Very High Very High Very High
Disease 113 99.26 Very High Very High Very High
INFLAMMATION 136 99.08 Very High Very High Very High
Seronegative Spondarthritis 202 98.88 Very High Very High Very High
Syndrome 9 97.56 Very High Very High Very High
Psoriasis 405 97.48 Very High Very High Very High
Apoptosis 18 97.16 Very High Very High Very High
Skin Diseases 8 94.04 High High
Rheumatoid Arthritis 80 92.64 High High
Arthritis 57 88.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This recombinant protein binds CD2 on T cells and Fc gamma RIII on accessory cells (e.g., natural killer cells, macrophages), inhibiting T cell activation/proliferation and inducing selective T cell apoptosis.
CD2 Binding (binds) of in accessory cells associated with apoptosis
1) Confidence 0.44 Published 2002 Journal J Pharmacokinet Pharmacodyn Section Abstract Doc Link 12795239 Disease Relevance 0.19 Pain Relevance 0.05
The immediate and marked suppression of ongoing EAN by the mAb lead to the recommendation of anti-CD2 mAbs as candidates for T cell directed immunotherapy of the GBS.
CD2 Binding (recommendation) of in T cell associated with syndrome and neuritis
2) Confidence 0.36 Published 1996 Journal Brain Section Abstract Doc Link 8813272 Disease Relevance 1.10 Pain Relevance 0.58
The peptides are produced after stimulation with the mitogenic monoclonal antibodies anti-CD2.1/2.2 and anti-CD28.
CD2 Binding (stimulation) of
3) Confidence 0.36 Published 1998 Journal J. Neuroimmunol. Section Abstract Doc Link 9600708 Disease Relevance 0 Pain Relevance 0.81
By binding to the CD2 antigen on T cells, alefacept prevents T-cell activation and triggers apoptosis, preferentially targeting memory-effector T cells [3].
CD2 Binding (binding) of in effector T cells associated with apoptosis
4) Confidence 0.36 Published 2006 Journal Arch Dermatol Res Section Body Doc Link PMC1461773 Disease Relevance 0.57 Pain Relevance 0.29
This study supports the notion that T cell activation plays an important role in chronic inflammatory diseases and effective blockade of the LFA-3/CD2 interaction may be useful for treating PsA.
CD2 Binding (interaction) of in T cell associated with inflammation, disease and arthritis
5) Confidence 0.33 Published 2005 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC1208938 Disease Relevance 1.22 Pain Relevance 0.44
The CD2+, CD4+ and CD8+ levels, which are closely associated with activity of T cells, were statistically unchanged except on day 8 after acupuncture (P < 0.05).
CD2 Binding (associated) of in T cells associated with acupuncture
6) Confidence 0.25 Published 2007 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2176150 Disease Relevance 0 Pain Relevance 0.24
Cell counts of CD2+, CD4+, CD8+, CD11b+, CD16+, CD19+ and CD56+ were evaluated for variations in T cells, B cells, macrophages and NK cells after acupuncture treatment.
CD2 Binding (counts) of in T cells associated with acupuncture
7) Confidence 0.25 Published 2007 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2176150 Disease Relevance 0 Pain Relevance 0.13
Blockade of the LFA-3/CD2 interaction, a key co-stimulatory pathway, can inhibit T-cell activation.
CD2 Binding (interaction) of in T-cell
8) Confidence 0.24 Published 2005 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC1208938 Disease Relevance 0.94 Pain Relevance 0.34
With its dual mechanism of action, alefacept blocks the interaction between the leukocyte-function-associated antigen (LFA)-3 and CD2 and thereby impedes the activation and proliferation of T cells.
CD2 Binding (interaction) of in leukocyte
9) Confidence 0.24 Published 2007 Journal Therapeutics and Clinical Risk Management Section Abstract Doc Link PMC2386357 Disease Relevance 0.28 Pain Relevance 0.09
Alefacept binds competitively to the CD2 on the surface of T cells with the LFA-3 portion of the drug and efficiently interferes with LFA-3/CD2 binding and thereby T cell activation (Miller et al 1993), whereas the Fc portion of alefacept engages the immunoglobulin receptor Fc?
CD2 Binding (binds) of in T cell
10) Confidence 0.24 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2386357 Disease Relevance 0.49 Pain Relevance 0.17
Alefacept binds competitively to the CD2 on the surface of T cells with the LFA-3 portion of the drug and efficiently interferes with LFA-3/CD2 binding and thereby T cell activation (Miller et al 1993), whereas the Fc portion of alefacept engages the immunoglobulin receptor Fc?
CD2 Binding (binding) of in T cell
11) Confidence 0.24 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2386357 Disease Relevance 0.38 Pain Relevance 0.13
Alefacept is a recombinant protein that binds to CD2 on memory-effector T lymphocytes, inhibiting their activation and reducing the number of these cells.
CD2 Binding (binds) of in effector T lymphocytes
12) Confidence 0.22 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721342 Disease Relevance 0.67 Pain Relevance 0.54
It competitively binds to CD2 cells on T cells to block its activation.
CD2 Binding (binds) of in T cells
13) Confidence 0.16 Published 2008 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2792605 Disease Relevance 0.13 Pain Relevance 0.07
Interaction of CD2 with its ligand, CD58 has been blocked by application of a soluble fully human recombinant fusion protein comprising the first extracellular domain of CD58 and the hinge, CH2 and CH3 sequences of human IgG1 (LFA-3-IgG1; alefacept).
CD2 Binding (Interaction) of in hinge
14) Confidence 0.13 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC2833981 Disease Relevance 0.78 Pain Relevance 0.21
Cell counts of CD2+, CD4+, CD8+, CD11b+, CD16+, CD19+ and CD56+ were evaluated for variations in T cells, B cells, macrophages and NK cells after acupuncture treatment.
CD2 Binding (counts) of in macrophages associated with acupuncture
15) Confidence 0.08 Published 2007 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2176150 Disease Relevance 0 Pain Relevance 0.13
Cell counts of CD2+, CD4+, CD8+, CD11b+, CD16+, CD19+ and CD56+ were evaluated for variations in T cells, B cells, macrophages and NK cells after acupuncture treatment.
CD2 Binding (counts) of in B cells associated with acupuncture
16) Confidence 0.08 Published 2007 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2176150 Disease Relevance 0 Pain Relevance 0.13
Cell counts of CD2+, CD4+, CD8+, CD11b+, CD16+, CD19+ and CD56+ were evaluated for variations in T cells, B cells, macrophages and NK cells after acupuncture treatment.
CD2 Binding (counts) of in NK cells associated with acupuncture
17) Confidence 0.08 Published 2007 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2176150 Disease Relevance 0 Pain Relevance 0.13

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