INT6467

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Context Info
Confidence 0.09
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.24
Pain Relevance 0.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Cnnm2)
Cnnm2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 24 96.82 Very High Very High Very High
antinociception 44 92.00 High High
Spinal cord 45 90.52 High High
tetrodotoxin 1 86.12 High High
epidural 3 79.80 Quite High
intrathecal 35 63.64 Quite High
Peripheral nervous system 2 59.16 Quite High
Antinociceptive 31 51.12 Quite High
Central nervous system 11 48.56 Quite Low
transdermal 1 21.36 Low Low
Disease Link Frequency Relevance Heat
Disease 20 88.96 High High
Communicable Diseases 1 87.52 High High
Radiation Sickness 1 86.52 High High
Cancer 1 83.44 Quite High
Malignant Neoplastic Disease 1 83.08 Quite High
Vomiting 17 81.16 Quite High
Paralysis 9 76.08 Quite High
Heart Rate Under Development 2 74.24 Quite High
Vertigo 23 74.08 Quite High
Sleep Disorders 5 73.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
AF-DX 116 (11[[2-[(diethylamino)methyl]-1- piperidynyl]acetyl]-5,11-dihydro-6H-pyrido[2,3- b][1,4]benzodiazepine-6-one) an M2-selective antagonist, shifted the oxotremorine-M dose-response curve to the right with a dissociation constant (KB) of 0.20 microM, consistent with the dissociation constants for binding at the M2 muscarinic receptor site (KD = 0.092 microM) and inhibition of adenylate cyclase activity (KB = 0.13 microM).
M2 Binding (binding) of associated with antagonist
1) Confidence 0.09 Published 1992 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1328607 Disease Relevance 0 Pain Relevance 0.21
Although there is the suggestion that it also binds with M2 and M3 receptor subtypes this has been refuted by recent studies [10].
M2 Binding (binds) of
2) Confidence 0.02 Published 2002 Journal BMC Pharmacol Section Body Doc Link PMC137595 Disease Relevance 0.30 Pain Relevance 0.38
Although the mechanism of action of diphenidol on the vestibular system has not yet been elucidated, it exerts an anticholinergic effect due to interactions with mACh receptors, particularly m1, m2, m3 and m4 [155].
m2 Binding (interactions) of
3) Confidence 0.01 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2866460 Disease Relevance 0.94 Pain Relevance 0.07

General Comments

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