INT6474

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Context Info
Confidence 0.69
First Reported 1992
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 34
Total Number 36
Disease Relevance 21.87
Pain Relevance 10.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL1RN) extracellular region (IL1RN) plasma membrane (IL1RN)
nucleus (IL1RN) intracellular (IL1RN) cytoplasm (IL1RN)
Anatomy Link Frequency
synovial fluid 4
plasma 4
cartilage 4
skeletal muscle 4
fibroblasts 4
IL1RN (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 101 100.00 Very High Very High Very High
Inflammatory mediators 17 100.00 Very High Very High Very High
metalloproteinase 88 99.92 Very High Very High Very High
rheumatoid arthritis 426 99.88 Very High Very High Very High
aspirin 8 99.76 Very High Very High Very High
Inflammation 475 99.48 Very High Very High Very High
cytokine 537 98.48 Very High Very High Very High
backache 42 98.04 Very High Very High Very High
Arthritis 115 97.52 Very High Very High Very High
Osteoarthritis 223 96.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 535 100.00 Very High Very High Very High
Rheumatoid Arthritis 590 99.88 Very High Very High Very High
Pressure Volume 2 Under Development 2 99.56 Very High Very High Very High
Disease 213 99.48 Very High Very High Very High
Severe Combined Immunodeficiency 24 99.14 Very High Very High Very High
Synovitis 7 99.04 Very High Very High Very High
Atherosclerosis 92 98.80 Very High Very High Very High
Low Back Pain 58 98.04 Very High Very High Very High
Experimental Arthritis 39 97.52 Very High Very High Very High
Osteoarthritis 235 96.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, Mahoney and colleagues [9] demonstrated that elevated gene expression of IL-1RI is induced in skeletal muscle after eccentric exercise.
Positive_regulation (induced) of Gene_expression (expression) of IL-1RI in skeletal muscle
1) Confidence 0.69 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2837019 Disease Relevance 0.88 Pain Relevance 0.19
In contrast to piroxicam and aspirin, aceclofenac 10 microg/ml and TNF-alpha 10 ng/ml increased almost 46 times the basal amount of IL-1Ra produced by OA chondrocytes.
Positive_regulation (increased) of Gene_expression (produced) of IL-1Ra in chondrocytes
2) Confidence 0.65 Published 2001 Journal J. Rheumatol. Section Body Doc Link 11764219 Disease Relevance 0.05 Pain Relevance 0
RESULTS: OA samples spontaneously produced higher levels of IL-1Ra than normal samples (130+/-2.3 vs 30+/-3.1 pg/mI).
Positive_regulation (levels) of Gene_expression (produced) of IL-1Ra
3) Confidence 0.65 Published 2001 Journal J. Rheumatol. Section Body Doc Link 11764219 Disease Relevance 0.07 Pain Relevance 0
Aceclofenac increases the synthesis of interleukin 1 receptor antagonist and decreases the production of nitric oxide in human articular chondrocytes.
Positive_regulation (increases) of Gene_expression (synthesis) of interleukin 1 receptor antagonist in articular associated with aspirin and antagonist
4) Confidence 0.65 Published 2001 Journal J. Rheumatol. Section Title Doc Link 11764219 Disease Relevance 0.09 Pain Relevance 0.31
In this study, the feasibility of ex vivo gene transfer of IL-1Ra to the IVD was investigated.
Positive_regulation (transfer) of Gene_expression (transfer) of IL-1Ra
5) Confidence 0.51 Published 2006 Journal Int J Exp Pathol Section Abstract Doc Link 16436110 Disease Relevance 0.50 Pain Relevance 0.43
When the infected cells were injected into disc explants, IL-1Ra protein expression was increased which was maintained for 2 weeks of investigation.
Positive_regulation (increased) of Gene_expression (expression) of IL-1Ra
6) Confidence 0.51 Published 2006 Journal Int J Exp Pathol Section Abstract Doc Link 16436110 Disease Relevance 0.20 Pain Relevance 0.12
Interestingly, Mahoney and colleagues [9] demonstrated that elevated gene expression of IL-1RI is induced in skeletal muscle after eccentric exercise.
Positive_regulation (induced) of Gene_expression (expression) of IL-1RI in skeletal muscle
7) Confidence 0.50 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2837019 Disease Relevance 0.88 Pain Relevance 0.19
IL-1, TNF-alpha, and LPS produced dose dependent increases in synthesis of IL-1Ra.
Positive_regulation (increases) of Gene_expression (synthesis) of IL-1Ra
8) Confidence 0.47 Published 2001 Journal J. Rheumatol. Section Body Doc Link 11764219 Disease Relevance 0.07 Pain Relevance 0
In the study presented, cells of a herniated lumbar disc were cultivated in vitro and analysed for interleukin 1beta (IL-1beta) and interleukin 1 receptor antagonist (IL-1Ra) production.
Spec (analysed) Positive_regulation (analysed) of Spec (analysed) Gene_expression (production) of IL-1Ra associated with antagonist
9) Confidence 0.47 Published 1998 Journal Cytokine Section Abstract Doc Link 9770331 Disease Relevance 0.08 Pain Relevance 0.21
In the study presented, cells of a herniated lumbar disc were cultivated in vitro and analysed for interleukin 1beta (IL-1beta) and interleukin 1 receptor antagonist (IL-1Ra) production.
Spec (analysed) Positive_regulation (analysed) of Spec (analysed) Gene_expression (production) of interleukin 1 receptor associated with antagonist
10) Confidence 0.47 Published 1998 Journal Cytokine Section Abstract Doc Link 9770331 Disease Relevance 0.08 Pain Relevance 0.21
Specifically, plasma levels of the IL-1 receptor antagonist (IL-1ra) increase dramatically after intense exercise, and accumulating evidence points to an effect of genetic polymorphisms on athletic phenotypes.
Positive_regulation (increase) of Gene_expression (levels) of IL-1 receptor antagonist in plasma associated with antagonist
11) Confidence 0.46 Published 2010 Journal BMC Med Genet Section Abstract Doc Link PMC2837019 Disease Relevance 0.10 Pain Relevance 0.23
These show IL-1Ra quickly extinguishes MDP expression but, in the absence of IL-1Ra, IL-1-driven MDP expression is maintained even in prolonged tissue culture outside the disease context of the spine.
Positive_regulation (absence) of Gene_expression (expression) of IL-1Ra in spine associated with disease
12) Confidence 0.45 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206387 Disease Relevance 0.28 Pain Relevance 0.22
Finally, we have shown that IL-1Ra can be effectively delivered to degenerate IVDs by injecting cells genetically engineered to overexpress IL-1Ra into IVD tissue, where it will significantly inhibit expression of enzymes implicated in degradation of the IVD.
Positive_regulation (overexpress) of Gene_expression (overexpress) of IL-1Ra
13) Confidence 0.42 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206387 Disease Relevance 0 Pain Relevance 0.06
In order to quantify production of RVFP/IL-1ra in the GI tract, three mice were sacrificed 3, 11, and 28 days after last bacterial inoculum.
Positive_regulation (quantify) of Gene_expression (production) of IL-1ra
14) Confidence 0.35 Published 2003 Journal BMC Biotechnol Section Body Doc Link PMC222906 Disease Relevance 0.24 Pain Relevance 0
The disease severity correlated with increased plasma levels of IL1RA, IL2, IL6, CCL3, CCL4 and IL10.
Positive_regulation (increased) of Gene_expression (levels) of IL1RA in plasma associated with disease
15) Confidence 0.33 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2948498 Disease Relevance 0.59 Pain Relevance 0.07
Allele 2 of this polymorphism was associated with increased production of IL-1 RN by monocytes and with higher plasma concentrations.
Positive_regulation (increased) of Gene_expression (production) of IL-1 RN in monocytes
16) Confidence 0.33 Published 2001 Journal Arthritis Res Section Body Doc Link PMC128892 Disease Relevance 1.46 Pain Relevance 0.26
Although levels of IL-1Ra and sTNFR are elevated in patients on HD, these levels reflect the host response to inflammation.
Positive_regulation (elevated) of Gene_expression (levels) of IL-1Ra associated with inflammation
17) Confidence 0.33 Published 1992 Journal Kidney Int. Suppl. Section Abstract Doc Link 1328757 Disease Relevance 0.44 Pain Relevance 0.25
Within most clinical conditions involving IL-1, an increase in IL-1Ra production is considered an excellent marker of disease, and often a better indicator than IL-1 itself [42].
Positive_regulation (increase) of Gene_expression (production) of IL-1Ra associated with disease
18) Confidence 0.31 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175026 Disease Relevance 0.25 Pain Relevance 0.05
In the current study, a marked increase in the proportion of cells immunoreactive for IL-1 were found in degenerate than in non-degenerate IVDs, but no similar increase in IL-1Ra-immunopositive cells was observed, indicating an imbalance in the local production of IL-1 and IL-1Ra and failure of the normal compensatory mechanism associated with increasing local production of IL-1.
Positive_regulation (imbalance) of Gene_expression (production) of IL-1Ra
19) Confidence 0.22 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175026 Disease Relevance 0.23 Pain Relevance 0.07
The induced endogenous production of IL-1Ra, in presence of the RA synovitis, is too low to contrast the high affinity of IL-1 for the cell receptors.
Positive_regulation (induced) of Gene_expression (production) of IL-1Ra associated with synovitis and rheumatoid arthritis
20) Confidence 0.16 Published 2004 Journal Reumatismo Section Abstract Doc Link 15201939 Disease Relevance 1.04 Pain Relevance 0.52

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